The article is devoted to the current problem of the formation of the professional personality of medical students from the point of view of basic values, such as citizenship and responsibility, corresponding to the new demands of society, lying in the plane of the modern Concept of Zhana Kazakhstan. The purpose of the article is to formulate the principle of the effectiveness of using a quiz in classroom and extracurricular work with students of medical specialties. The authors offer a specific scenario for the quiz «Medical Karaganda», and at the same time describe in detail the tasks and the course of the game. The tasks are based on materials on the history of medicine in Karaganda, including unique archival sources, materials collected in museums and other sources. The quiz also involves conducting it in the second language that the students are studying (in this case, Russian for students in groups with Kazakh as the language of tuition). The article analyzes both the effectiveness of individual tasks and the quiz as a whole. The analysis was carried out based on the results of testing a quiz in the classroom (NС JSC «Karaganda Medical University», 1st year students) and as part of the «City Day» event at the private institution «Bolashaq Academy» with students of the specialty «Pharmacy». Analysis of the results obtained during feedback and questioning proved the effectiveness of the quiz in the formation of basic values (patriotism, responsibility, critical thinking) and allowed us to formulate the principle of effectiveness based on a careful selection of tasks and interdisciplinary connections.

This article displays the results of a review of scientific research on the speech methods of responding to victims of sexual violence, taking into account Internet communication. When conducting the review, the results of scientific research from different countries of the world community were used to more fully describe the topic under study, taking into account the cultural and intercultural characteristics of different regions and countries. Emphasis was also placed on other factors influencing the way a victim of violence responds in speech format, such as individual and psychological characteristics, the factor of the context of the situation, and social factors. The consequences of the response of victims of sexual violence, such as the psychological state of the victim, and the consequences for subsequent social interaction are described in detail. After a review of the literature, conclusions and conclusions were drawn that characterize the importance of the research work carried out for use by professionals providing assistance to survivors of sexual violence.

Aim of the study. Analysis of breast cancer incidence in Kazakhstan for the period 2020 – 2022.

Materials and methods. The study included all registered cases of breast cancer morbidity and mortality in the Republic of Kazakhstan for the period 2020-2022. Data for analysis were taken from the official statistical source: Statistical collection «Health of the population of the Republic of Kazakhstan and the activities of healthcare organizations in 2020»; Statistical collection “Health of the population of the Republic of Kazakhstan and the activities of healthcare organizations in 2021-2022.” The search depth was 3 years, from 2020 to 2022. A direct standardization method using a global population standard was used to calculate standardized morbidity and mortality rates.

Results and discussion. As a result of studying statistical data for 2020-2022, it was found that cancer incidence rates per 100 thousand population in 2022, compared with 2021, increased by 5.2%, and compared to 2020 increased by 13.5%. In the structure of incidence, both in 2020 and 2021, and in 2022, breast cancer occupied 1st place, with an increase in dynamics from 2020 to 2022 from 8.76 to 9.73 per 100 thousand population.

An analysis of the incidence of breast cancer by stages of the disease in the context of regions of Kazakhstan showed that high rates of stages I and II of breast cancer were established in the Kyzylorda, Pavlodar, and Atyrau regions. The lowest incidence rates of stage I and II breast cancer were observed in Akmola, Mangistau and Turkestan regions.

Conclusions. According to the results of our review, many studies indicate that this disease continues to be the most frequently diagnosed malignant neoplasm and the leading cause of death among women in various countries of the world, including Kazakhstan. The conclusion of this article is that the incidence and mortality from breast cancer continues to be an urgent epidemiological problem in Kazakhstan, requiring further scientific research to identify risk factors.

Objective. To identify and analyze the groups of women who contribute the greatest and least to the frequency of caesarean sections in general. Conducting an assessment of the frequency of caesarean sections in the Regional Perinatal Center №1 of the Turkestan region according to the classification of M. Robson.

Materials and methods. We conducted a retrospective analysis of the history of 5286 births in the Regional Perinatal Center No. 1. The history of childbirth of women who gave birth in 2022 was taken into account. According to the history of each birth to complete the table: method of delivery (delivery through the birth canal, caesarean section); parity (first time , repeated); number of fetuses (one, two, three or more); delivery period (up to 37 weeks., 37-40 weeks., 41-42 or more); type of fetal malformation (head, pelvis, transverse/ oblique); induction of labor (induction was carried out, induction was not carried out); spontaneous childbirth; the number of caesarean sections in the history (one or more) was taken into account.

Results and discussion. The group contributed the most to the total CS frequency were 5 groups – with a history of one or more CSs, one fetal head arrival, ≥37 weeks – 24.1%; the group contributed the least to the total CS frequency was 9 groups – single fetal pregnancy, women with a horizontal or oblique fetal position, including women with a history of one or more CSs – 2.2%.

Conclusion. The largest share of the group in the total frequency of CSwas Group 5 – 22.1% of all births, 888 (75.9%) of 1,170 women in this group underwent surgery, all pregnant women with scars on the uterus ; group 9 – 0.7% of births accounted for the smallest share of the group in the total frequency of CS, 100% of 38 women gave birth with CS.

Aim of the study. To assess the impact of the COVID-19 pandemic on the incidence of lung cancer by component analysis.

Materials and methods. The research material was the data of the Ministry of Health of the Republic of Kazakhstan concerning LC (Form 7). To analyze the dynamics of incidence based on the number of cases from 2011 to 2020, a component method was used.

Results and discussion. Analyzing 2011 and 2020, we found a tendency to decrease the incidence of lung cancer (p=0.000). However, comparing 2019 and 2020, we found a sharp decline in the incidence. The overall decrease was −2,22⁰/₀₀₀₀ and depended on changes in the age structure of the population (∑ΔA=+0,34⁰/₀₀₀₀), the risk of getting illness (∑ΔR=−2,52⁰/₀₀₀₀) and the combined effect of the age structure and the risk of getting illness (∑ΔAR=−0,04⁰/₀₀₀₀). The decrease was mainly due to the impact of the risk of getting illness. According to the calculations of the component analysis, 3,856 patients were expected in 2020, but instead the number of patients decreased to 3,375 and this is characterized by a decrease in the number of cases as a result of changes in the risk of getting illness.

Conclusions. The COVID-19 pandemic has significantly reduced the incidence rate of lung cancer in Kazakhstan. Additional analysis and research are needed to understand the full impact and take appropriate measures to combat cancer in a pandemic.

Massive infections of people with the previously unidentified SARS-CoV-2 virus have been a shock to the global healthcare system. While many studies have focused on the clinical manifestations of the disease and its treatment methods, understanding the molecular and genetic aspects of infection has proved critical to understanding the pathogenetic mechanisms of host-pathogen interaction. The scientists focused on issues of gene expression and their regulation in response to SARS-CoV-2 infection. In particular, we conducted a study of gene expression within the framework of the project «COVID-19: Scientific and technological justification of the response system to the spread of new respiratory infections, including coronavirus infection», the results of which are presented in the article [1].

Hence, variations in the gene expression profiles of TLR 3 (Toll-Like receptor), TLR 7, TLR 4, ACE 2 (Angiotensing converting enzyme), TMPRSS 13 (Transmembrane serine protease), INF-Ɣ (Interferon gamma), and IL 4 (Interleukin) were discerned across all investigated cohorts, including those assessed six months post-recovery. 

There is a complex of pathways of immune system to defense with the infection including the involvement of toll-like receptor signaling pathways which contact of viral particles. Moreover, the surge in ACE2 expression demonstrates the multifunctional role as gates for Sars-Cov-2 to enter cells and activation of innate immunity responses. Although, the upregulation of INF-Ɣ and IL-4 as proinflammatory cytokines were contributed to the initiation and the progression of the cytokine storm.

The 2019 coronavirus (COVID-19) pandemic has reached more than 194 million people as of July 26, 2021, and continues to spread worldwide. During the course of the long pandemic, evidence of damage to various organs and systems, such as the nervous system and parts of it, began to emerge. Oxidative stress is one of the main causes of neuronal dysfunction and death, mainly due to excessive formation of reactive oxygen species and depletion of antioxidant reserves. Oxidative stress is characterized by an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense mechanisms of the body. This process is involved in the onset and development of many neurological diseases. In this review, we analyzed and summarized the results of studies showing the association of neurological diseases, such as stroke, Parkinson's disease, and other neurological diseases, with excessive formation of oxidative stress products. This article aims to provide an overview of the relationship between oxidative stress and a range of neurological conditions, shedding light on the underlying mechanisms and potential therapeutic implications. Objective of the study was to determine the level of anxiety-depressive disorders among patients who underwent COVID-19. 90 people were examined and selected according to inclusion and exclusion criteria. To assess higher nervous functions, we used the hospital scales HADS I, HADS II, Beck depression scale. To date, our study has not found a clear link between the virus in the body and anxiety-depressive manifestations in patients, which may suggest that the main cause of the disorders lies in the social aspects of the pandemic. 

Thrombotic complications often complicate the course of the underlying disease in patients with chronic myeloproliferative neoplasia. However, a thromboembolic condition is not observed in all patients.

The aim of the study was to assess the carriage frequency of polymorphic genes of the blood coagulation system and folate metabolism genes and the contribution of genetic variants to the development of thrombosis in patients with chronic Ph-negative myeloproliferative neoplasia (CMPN).

Materials and methods. Molecular genetic testing for the presence of genetic variants with an assessment of their frequency of occurrence and allelic load was carried out in 142 patients with CMPN. We studied polymorphisms of the folate cycle genes – A2756G (Asp919Gly) of the MTR gene, C677T (Ala22Val) of the MTHFR gene, A66G (ILe22Met) of the MTRR gene (rs1801394), as well as mutations of the genes of blood coagulation factors – G(455)A of the FGB gene, G20210A of the F2 gene, G10976A (Arg353Gln) of the F7 gene, G1691A (Arg506Gln) of the F5 gene. The study was carried out using real-time polymerase chain reaction (PCR); The biological material for the test was whole blood.

Results and discussion. The study showed that only 6 out of 50 (12%) patients with thrombotic complications had no changes in the genes studied, while 88% of patients had one or another genotypic variant, which may indicate a high probability of involvement of a hereditary genetic factor in the development of hypercoagulability and thrombotic complications in patients with chronic MPN.

Conclusions. A comprehensive study of the role, interaction and operating conditions of genes that control blood coagulation processes in patients with Ph-negative chronic MPN will make it possible to understand the causes of hemostatic system disorders and develop effective measures to prevent thrombotic complications in this category of patients.

The new coronavirus infection caused by the SARS-CoV-2 virus has become a serious problem worldwide. COVID-19 is primarily a respiratory tract infection. Viral lung damage caused by SARS CoV-2 is commonly interpreted as COVID-19-associated pneumonia. Patients with severe course of the disease have more pronounced violations of laboratory blood parameters. A general blood test of patients with COVID-19associated pneumonia refers to non-specific laboratory diagnostic methods and at the same time plays an important role in assessing the severity of the condition, as well as allows predicting the course, development and outcome of the disease. The aim of the study was to study peripheral blood counts in hospitalized patients with COVID-19-associated pneumonia. A retrospective analysis of the medical histories of patients with COVID-19 associated pneumonia was carried out. The presence of the SARS-Cov-2 virus was confirmed by polymerase chain reaction. The examination of patients was carried out according to the current protocol "Coronavirus infection COVID-19 in adults". Hematological parameters in patients with moderate and severe pneumonia were analyzed. CT-2 and CT-3 predominated in terms of lung tissue damage. The results of the study revealed changes in the general analysis of peripheral blood, such as a decrease in lymphoid cells, the absence of reactive leukocytosis to acute inflammation, and thrombocytopenia. The changes depended on the severity of pneumonia and the presence of concomitant pathologies.

To identify the most revealing studies in the field of non-cosmetic medical use of hyaluronic acid and determine its prospects for further use in the treatment of problems with the temporomandibular joint.

The material for the work was the research of specialists from Mexico, Italy, the USA and Russia, analyzing the use of hyaluronic acid in various areas of joint treatment.

An analysis was made of five large studies on this topic, during which patients with joint diseases received intra-articular injections of hyaluronic acid using samples. Patients, depending on the purpose of a particular study, were asked to take a course of hyaluronic acid and a placebo / other medicinal substance.

As a result of the analysis, it was found that most of the above studies showed a positive effect of hyaluronic acid in the short and long term in the treatment of diseases of the temporomandibular joint. At the same time, in order to further expand the use of this substance, additional research is required in specific areas. 

The emergence of e-learning platforms as a potential means of advancement is not new, but their use has increased significantly during the COVID-19 epidemic. Distance learning presents users with not only problems but also user-centered solutions. The purpose of this study is to review the literature on e-learning platforms used in medical schools to formulate a research strategy to implement an e-learning platform for surgical competency control. To achieve the objective, a search was conducted for articles cited in PubMed, Research Gate, Google Scholar, Web of Science and Scopus databases from journals and conference proceedings published between 2015 and 2023. Literature in the study area was systematized to explore the experiences of users of e-learning platforms in medical schools to provide a basis for a methodological framework.

The proposed structure or content analysis model can be used for further e-learning research and guide the successful implementation of e-learning and surgical competency monitoring systems in medical HEIs. An important area of focus is the study of the advantages and disadvantages of specific e-learning methods, as their benefits have not been fully explored and are mainly related to e-learning platforms. Here we consider various features of e-learning in the context of its implementation in the system of medical education in Kazakhstan and other foreign countries.

Introduction. The increasing proportion of the aging population and overweight people with various joint problems leads to an increased demand for joint replacements. As the number of joint arthroplasty surgeries continues to rise, the persistent incidence of periprosthetic joint infections highlights the need for a comprehensive and evolving approach. In addition to the preoperative period, it is also necessary to consider the course of the intraoperative, and to a greater extent the postoperative period, when the development of periprosthetic infection occurs. This case is indicative of the fact that underestimation of the importance of the postoperative period and control of risk factors can lead to the recurrence of infection. This negatively affects the economy due to an increase in the number of disabilities.

Case presentation. A 60-year-old female patient was diagnosed with a periprosthetic joint infection following total knee arthroplasty. The patient's premorbid background was aggravated by the presence of type 2 diabetes mellitus, arterial hypertension, secondary cardiomyopathy, and chronic iron-deficiency anemia. Single stage revision of knee arthroplasty, removal of prosthetic components, excision of degenerative tissue, prolonged antibiotic therapy as well as rehabilitation were ineffective, and the pain increased. Therefore, the patient is admitted for the two-stage revision surgery, removal of the endoprosthesis, and installation of a nonarticulating cement spacer of the left knee joint.

Conclusion. Through a relevant literature search, we believe that uncorrected chronic iron-deficiency anemia in combination with uncontrolled diabetes mellitus, both in the preoperative and postoperative period for joint replacement, may increase the risk of the development of periprosthetic infection. Moreover, focusing patients' attention on the importance of the postoperative period and strict monitoring of health indicators will help reduce the likelihood of re-prosthetics.