The purpose of the study. To consider the phenomenon of the key values of Zhana Kazakhstan and the peculiarities of their formation in the process of language education; to propose the most effective combination of methods of language training for medical students and enlightenment methods of future professionals within the framework of a nationwide idea.

Materials and methods. The article describes the experience of working with 1st year students of Karaganda Medical University NC JSC in Russian language classes at the B1 level in the aspect of the formation of key values of the Republic of Kazakhstan.

Results and discussion. Based on the results of the teaching experience, the most effective ways of Zhana Kazakhstan values forming are proposed. The topics on the Russian language subject in the framework of the Standard Program and the key values were identified by the President of the Republic of Kazakhstan at the third Kurultai, and they are correlated in terms of their potential for the formation of a particular value. Special attention is paid to the problem of selecting material for classes in the listening and reading modules (types of speech activity) as well as on topics proposed for discussion. The article describes examples of this material with active forms of learning using in a classroom.

Conclusions. The forms of activation of work are proposed: discussion, quiz, meetings. The techniques of working with texts and interrelated learning of listening and reading based on the material of the proposed texts and videos are described. The effectiveness of the proposed tools for the formation of key values of Zhana Kazakhstan is confirmed by the results of oral and written questionnaires of students during feedback. 

Immunology is a branch of medicine that studies the immune system and its pathology. There are known scientific information, that in medical immunology specific tests performed in the laboratory for diagnosis. In addition, good to mention that allergies include medical diagnostic methods such as blood tests. Also, there are used for detection the presence and the levels of IgE antibodies. Currently within the present description aim to discuss some aspects referring to fungal allergen and mold allergy diagnosis, in a shortage following steps of our purposed description.

Molds produce mycotoxins, unfortunately with carcinogenic, teratogenic and neurotoxic properties, with a possible negative impact on individual healthy. Allergies related to fungi together with comorbidities, mainly concern immunocompromised patients. The currently describing knowledges in the field of allergy between fungal allergens and human subjects, and also established the diagnosis and treatment, offer us a complex vision. For the future, hope to find into the research studies, proper knowledges in this field, with applicability in routine practice. 

The cardiovascular system is considered as an indicator of adaptive activity of the whole organism, where an unstable indicator is the heart rate, which changes even with minor physical activity. The article shows the change in cardiovascular parameters of the main and auxiliary workers of the aluminum plant under the influence of physical factors of the production environment. The type of reaction of the hemodynamic system in the main working professions is mainly designated as vascular, where the load reaction was accompanied by the most pronounced changes in the peripheral part of the hemodynamic system: an increase in systolic and diastolic blood pressure, heart rate. Employees of auxiliary specialties reacted to the load by increasing diastolic blood pressure.

Introduction. Measles continues to be one of the major public health problems, despite the existing effective and safe vaccines.

The purpose of the study is to analyze the long-term dynamics of the epidemic process of measles in Kazakhstan and Aktobe region in 2004-2023.

Materials and methods. Statistical data on measles incidence rates from the websites of the Ministry of Health of the Republic of Kazakhstan (MOH RK), the Committee for Sanitary and Epidemiological Control (SEC) of the Ministry of Health of the Republic of Kazakhstan and statistical reports of the SEC Department for the Aktobe region. The design of the study is descriptive and retrospective. The data obtained were processed using statistical programs Excel and Statistica 10.0.

Results: in the Republic of Kazakhstan, from 2004 to 2023, there was an increase in morbidity in 2005. The period of epidemiological well-being for measles was the time period from 2006 to 2014, when the incidence rate fluctuated between 0.7 and 1.0. In 2015, the indicator was 13.5, followed by a decrease in case registration by 0.7% in 2016. Since 2019, there has been a sharp increase in morbidity rates by 24 times (in 2019 – 72.9 (per 100 thousand population), in 2018 -3.2. 0 significant increase in morbidity: 29,648 confirmed cases were registered in the country, among them children under 14 years old accounted for 80%, in the Aktobe region – 2,179 and 79%, respectively, urban residents were sick 2-3 times, and in 2015 even 20 times more often than rural ones. The disease was mainly registered among unvaccinated children (58.3%) due to the failure to reach the vaccination age – 47.3%, medical withdrawals – 30.4% and refusals – 22.3%.

Conclusions: the increase in the incidence of measles is due to factors such as uneven vaccination coverage in the whole country, a low level of public responsibility, increased incidence of measles in neighboring countries and a high level of population migration.

Aim of the study. Study of the role of the main risk factors for community-acquired pneumonia in children.

Materials and methods. The study was conducted among 136 children with pneumonia out of hospital, aged 3 to 14 years. Among them, 37% were boys undergoing treatment in a specialized department. During the study, all children were divided into groups according to severity (groups I, II and III). The diagnosis was verified on the basis of clinical, anamnestic and laboratory fundamental data in accordance with the diagnostic protocol of the Republic of Kazakhstan. Statistical analysis of the obtained data was carried out using standard methods of variation statistics, assessing the correctness of the differences.

Results and discussion. The most important risk factors in the examined children were: increased blood pressure during pregnancy (59.4+4.21); excessive work of the mother during pregnancy (48.4+3.17); early artificial feeding in the 1st year of life (61.5+4.93); manifestations of protein-energy deficiency in the 1st year of life (53.9 + 3.53), respectively, discrepancy between weight and height in the 1st year of life (33.9 + 3.11) and rickets in the 1st year of life child and pneumonia factors (46.9+4.11; 40.5+3.21).

Conclusion. The study determined the varying degrees of occurrence of risk factors depending on the severity of community-acquired pneumonia in the examined children. The results obtained indicate the need to take into account risk factors to determine the severity of the disease as an additional criterion.

Purpose of the study. Improving the treatment of patients with acute pancreatitis complicated by endogenous intoxication and septicemia by including plasmapheresis in intensive therapy.

Materials and Methods. 24 patients with acute pancreatitis, 19 - 65 years old, 17 men (70.8%) and 7 women (29.2%), treated in the ICU of the Central Hospital of Almaty were studied. Patients were divided into 2 groups: the main group (11 men and 4 women) received standard intensive therapy with plasmapheresis, the control group (5 men and 4 women) received only standard intensive therapy with forced dieresis.

Results and Discussion. At the beginning of treatment in both groups there was an increase in the levels of erythrocytes and hemoglobin, which then significantly decreased. By day 7, normalization of leukocytes was observed in the main group (9.51±1.69), while in the control group they remained elevated. Leukocytic intoxication index in the main group by day 3 decreased by 41.1%, compared to the control group. The level of total protein in the main group by 3-5 days increased by 13.4%, compared to the control group. Urea and creatinine levels in the main group normalized by day 3 (8.9±4.15 and 99.47±70.61), in the control group - remained elevated. Decrease of total bilirubin level to normal values (20.9±16.9) was recorded in the main group by day 5. In both groups, between days 3 and 5, there was a decrease in fibrinogen levels to normal. Prothrombin index was initially decreased in both groups, but by day 3 in the main group the values stabilized (75.69±5.1). In the main group there was a significant decrease in the mean APACHE II score and decrease in the degree of endotoxemia on the 2-3 day after the operation, in the control group these values were observed only by the 12th day. The percentage of fatal outcomes in the control group was 53.1%, in the main group - 10.3%.

Conclusions. In acute destructive pancreatitis complicated by surgical sepsis, marked endotoxemia is often observed, which is reflected by an increase in the leukocytic index of intoxication. In such cases, treatment should specifically focus on the elimination of endotoxemia, a key element contributing to the development of multiorgan dysfunction. The use of plasmapheresis stands out for its ability to effectively remove endotoxins from the bloodstream, thereby preventing the deterioration of multiorgan function and reducing the risk of mortality in patients suffering from this disease.

The aim of the study was to identify structural characteristics of melanocytic nevi. In this context using microscope, could be possible a good description related melanocytic nevi, referring to youth patients. Good to mention that in a human individual life, play a significant role, genetic, epigenetic, microbiomic, and proteomic factors together with others. Future directions refers to preventive and prophylactic methods.

The author made a conclusion that prevention and educational methods, are important. More than early detection in melanocytic nevi is a great point in order to try to treat and to avoid maybe possible malignancy degeneration. Techniques for the laboratory diagnosis that are implications in monitoring previously pathological status, are implied and conduct to a proper quality of life in patients diagnosed with melanocytic nevi. In this direction, implication of an interprofessional team strategies is one of the proper conditions.

Purpose of the study. Study ABC/VEN analysis indicators, identify the most expensive medications and determine ways to rationalize costs in the Occupational Health Clinic of Karaganda Medical University NC JSC.

Materials and methods. The material for the study was material records of the purchase of medicines within the framework of the guaranteed volume of free medical care and compulsory social health insurance for the treatment of patients for 2023. For the ABC/VEN analysis drugs were grouped by international nonproprietary names (INN). The VEN-analysis of drug costs with assignment of an index of evidence/importance of drugs was carried out in comparison with the Kazakhstan National Medicines Formulary, the World Health Organization Model List of Essential Medicines and the British National Formulary.

Results and discussion. The ABC/VEN analysis indicators for the purchase of Medicines in the Occupational Health Clinic of Karaganda Medical University NC JSC for the treatment of patients within the framework of the GAFMC/CSHI. The analysis of the financial costs of drug provision in accordance with the structure of treated patients with occupational diseases, rationality and effectiveness was carried out.

Conclusions. It was established that in the Occupational Health Clinic of Karaganda Medical University NC JSC according to ABC/VEN analysis, the financial costs of drug provision within the framework of GAFMC/ CSHI were appropriate, corresponded to the structure of treated patients with occupational diseases. 

The aim of the study. There was a study of indicators of the quality of care provided in a comparative aspect at the primary level, as well as at the specialized level of the tertiary center.

Materials and methods. Retrospective analysis of outpatients and inpatients with IBD followed at a tertiary center. Analyzed quality indicators: time to start therapy at the onset of the disease; proper use of steroids; monitoring the safety of immunobiological therapy and others.

Results and discussion. The prevailing majority of patients were observed in general gastroenterologists (75.2% with Crohn's disease and 53.6% with ulcerative colitis, respectively, p<0.021, than in gastroenterologists specializing in IBD (24.8% and 46.4%, respectively, p><0.021). Patients with Crohn's disease were significantly more often diagnosed after the first emergency hospitalization (59.4%, p<0,012) first-time inpatient therapy was prescribed (58.8%, p<0,002), surgical intervention was more often required (36.2% p<0,002), as well as more than 2 courses of steroids (27.9%, p<0,030). Before the appointment of immunosuppressive therapy, tuberculosis screening is carried out in 68.6% of cases of IBD, testing for viral hepatitis - 83.5% of cases; Cl. Difficile and CMV, if indicated, were excluded only in a third of patients with IBD (28.2%, p<0,046 and 38,3%, p<0,024 respectively). IBD specialists are more likely to be referred for primary endoscopic examination (82.3%) in comparison with PHC specialists (52.4%, p<0,01). Regular (endoscopic) screening for dysplasia, taking into account risk factors, was performed only in 41.2% in CD and 30.8% in UC; the recommendation was given in 62.9% of cases by IBD specialists and 20.6% of cases by primary care physicians

Conclusions. Given the complex nature of the pathology, the lifelong disabling course, it is necessary to expand access to specialized care, raise awareness of primary care specialists about early diagnosis measures, pathogenetic therapy aimed at preventing complications.

This article discusses a clinical case of the onset and course of Graves' disease against the background of long-term antiretroviral therapy, interferons. The complexity of this case was the resistance of thyrotoxicosis therapy, as well as the impossibility of prescribing the necessary doses to normalize the thyroid profile due to the drug's hepatotoxicity. During the treatment of thyrotoxicosis, an increase in liver enzymes occurred. The tactic was adopted to perform a thyroidectomy with sedation. After normalization of liver function for a period of 2 months, it was possible to achieve subcompensated thyrotoxicosis by taking Tyrozol 40 mg per day. After the strumectomy, the patient’s condition was much better. Started hormone replacement therapy, thyroid status returned to normal. It was concluded that it is necessary to exclude the development of thyrotoxicosis by determining the level of TSH, the levels of free thyroxine and triiodothyronine, the determination of antibodies to thyroperoxidase, antibodies to the TSH receptor before starting antiretroviral therapy and interferon therapy.