At present, limited use of donor tissue and organs, problems of transplant rejection and many possible complications remain unresolved problems and are an actual problem of practical urology. The aim of the study was to study the extracellular matrix from animal raw materials in urology as a reconstructive biological material. The search for alternative materials led to the study of the use of decellularized bovine-derived peritoneum. The published data, at 20 years old, we have not met for the application of decellularized bovine-derived peritoneum in nephropexy

The presented review studies the prevalence of gingival recession. Analysis of the published data on the problem of the high prevalence of gingival recession, as well as the poorly studied prevalence and the peculiarities of the gingival recession manifestation in patients with dentofacial anomalies and teeth dystopia, indicate the need for the development of a diagnostic and prophylactic algorithm in order to estimate the prognosis and possible complications and also to make effective complex treatment.

Article shows analysis of the orthopedic treatment under retriction defect of convertion teeth. Protocol of the restoration teeth row integrity with applying implants has some flaws. Emptiness which forms by convergent tooth and artificial crown on dental impant, pushes patological movement and conduce morfological changes in problem zone.

Breast cancer is a malignant tumor of the glandular tissue of the breast. According to IARC, 167,114 new cases of breast cancer are registered in the world annually. In the structure of oncological pathology, this localization takes first place for many years. 10-12% of the world's total is breast cancer out of ten million new cases of malignant diseases. According to research in the US, the incidence of breast cancer is steadily increasing in older women, namely after the onset of menopause. These age-specific morbidity rates are higher in Caucasian women than afroamericans. Although the mortality rates from breast cancer in black women are higher. In Kazakhstan breast cancer takes the first place among other cancers in women. Unfortunately, the incidence rate is increasing year by year. There are differences in the incidence of breast cancer among diverse ethnic groups, this is associated with the traditions and way of life of various peoples. The issue of racial differences in patients with breast cancer (BC) has recently become more topical. In the era of individualization of treatment, knowledge of ethnic characteristics, such as tumor aggressiveness, its immunohistochemical characteristics in representatives of different nationalities, seems necessary and logical. A conducted literary search has shown that that question is more covered only in the United States of America (USA). The similar studies are not available or they are of a single character with a small sample of patients in Europe, Asia, Africa, South America.

The article considers the problems of purulent inflammatory processes of the maxillofacial area, which in recent years remain one of the urgent problems of maxillofacial surgeons. This is due to the high incidence of such diseases, changes in nonspecific and immunological reactivity of the organism due to chronic stress, eating disorders, alcohol abuse, drug dependence, uncontrolled intake of antibacterial drugs, adverse environmental situation, increased severity of the course and prevalence of the inflammatory process, changes in their clinical manifestation, such complications as, cavernous sinus thrombosis, brain abscess, mediass Tinite and septicemia, which can lead to death. Currently, the purulent inflammatory processes of the maxillofacial area are increasingly beginning to acquire a combined character of the lesion, as they spread to other areas, thereby attracting specialists in other areas to treatment.

In order to evaluate the state of health of the population in the v. Toretam and v. Akay, adjacent to the area of the accident «Proton-M» in 2013 at the cosmodrome «Baikonur», screened in comparison with a control v. Aiteke bi. 665 people were examined in Toretam, 270 in Akay and 665 in Aiteke bi. It was revealed according to the standardized indicators, depleting age and sex differences, that have examined from the v. Akay level of pathological affection is much higher than in the v. Aiteke Bi comparison, in terms of general pathology, cardiovascular diseases, digestive, musculoskeletal and endocrine systems. In v. Toretam also much higher than in the control village Aiteke Bi, standardized indicators of general pathological prevalence and incidence of digestive diseases, musculoskeletal and endocrine systems. In the village of comparison Aiteke Bi for intensive and standardized rates the largest number of healthy people. The revealed distinctions of levels of a pathological prevalence demand more in-depth studies.

TO THE PROBLEMS OF CEREBROVASCULAR PATHOLOGY AMONG THE POPULATION OF THE COUNTRIES OF THE WORLD. CEREBROVASCULAR DISEASE BY MORTALITY IS ONE OF THE LEADING PLACES IN THE RANKS OF THE COUNTRIES OF THE WORLD. AND TODAY IN THE WORLD, STROKE IS DECLARED A GLOBAL PROBLEM, THREATENING THE HEALTH AND LIFE OF PEOPLE. EVERY YEAR IN THE WORLD, MORE THAN 17 MILLION PEOPLE SUFFER FROM STROKE, OF WHICH MORE THAN 70% LIVE IN MIDDLE-INCOME OR LOW-INCOME COUNTRIES. IN THE REPUBLIC OF KAZAKHSTAN STROKE IS THE THIRD MOST COMMON AFTER MYOCARDIUM AND MALIGNANT NEOPLASM.

The serological monitoring of population and also its condition of collective immunity is an indispensable element epidemiological surveillance of vaccine-preventable infections. The aim of the study was to study serological monitoring of postvaccinal immunity of the population against measles. According to the results of serological monitoring, 80% of the examined were assigned to 1 indicator group, aged 15 to 25 years. Analysis of the titres of immunoglobulin G showed that the average titer level of antibodies to measles virus was 2.34 IU/ml (CI 2.19-2.49). According to the distribution of titers of immunoglobulins G by age, it has been shown that the largest scale of titers up to 18 IU/ml is observed at the age of 45 to 50 years.

AIDS is one of the most important problems facing humanity at the end of the 20th century. Currently, more than 40 million people with HIV are officially registered in the world. AIDS is one of the five major diseases that carry the greatest number of lives on the planet. AIDS is one of the most important problems facing humanity at the end of the 20th century. Currently, more than 40 million people with HIV are officially registered in the world. AIDS is one of the five major diseases that carry the greatest number of lives on the planet. HIV affects not only the health of an individual, but also the state and society as a whole. The problems that arise in society due to the spread of HIV affect one way or another all of us.

Brain stroke is one of the main source of disability worldwide and, in particular, in Kazakhstan, creates a permanent disability of the population. In 2014, 6.7 million people died of stroke in the world. On the present day in the world, the average level of deaths during the first 4 weeks after a stroke varies between 17-34%. The level of annual survival in the economically developed countries varies from 57-92%. In Kazakhstan, the 28-day mortality rate is 22.4%, and the one-year survival rate is 67.7%. In paper the analysis of mortality of patients from the cerebral circulation disease in the Karaganda region is shown.

Cerebral stroke remains the main medico-social due to prevalence among the population, accompanies high rates of disability and mortality. In 2004, WHO, the World Stroke Federation and the World Congress on Stroke (Vancouver, Canada) addressed a message in which a stroke is declared a global epidemic that threatens the lives and health of the world's people.

100 children from 2 to 10 years of age including with bronchopulmonary pathology of viral-bacterial etiology were examined for the purpose of studying the clinical efficacy and safety of the use of Inspiron. The main group of 50 children received Inspiron, control (50 people) - ambroxol. The efficacy and safety of the drug was assessed by the dynamics of bronchial obstructive syndrome, cough, dyspnea, physical parameters of the respiratory system, tolerability and the presence of allergic reactions. The carried out researches have shown high efficiency of the preparation «Inspiron». A pronounced broncho-obstructive, mucolytic, antitussive effect was revealed, and an easier withdrawal of sputum was recorded. In no case are allergic reactions or laryngospasm recorded. There was a significant reduction in the stay of children in the hospital, which led to a reduction in the costs of the medical institution for treatment and examination.

The aim of the present study is to highlight the seasonal cases diagnosed with chronic obstructive pulmonary disease, present in the specialized medical service with acute symptomatology. In order to establish a more accurate diagnosis, besides the specialized medical examination, paraclinical investigations such as standard pulmonary radiography and spirometry, were used.

Currently, cardiovascular and bronchopulmonary pathologies are the most urgent medical and social problems, in connection with maintaining a high level of mortality and morbidity. The present paper aims to bring attention to selected cases of patients who have carried out medical examination of acute respiratory symptomatology. Selected patients for the present study have comorbidities, acute and/or flare-up of chronic respiratory diseases and cardiovascular diseases requiring a pacemaker implant. Following routine investigations, including standard chest x-ray and anamnesis, had shown the combination of respiratory and cardiac symptomatology. This study also increased awareness of their condition, risks in patients with these diseases.

Objective: to estimate the level of the biomarker of endothelial dysfunction FABP4 and to study its interrelation with the risk of developing DM type 2. Materials and methods: the cross-sectional trial was conducted among 389 respondents in the East Kazakhstan region, from 18 to 65 years old. The risk of developing DM type 2 was assessed using the FINDRISK scale. The serum level of the FABP4 biomarker was determined by multiplexing investigation an immunofluorescence method using XMap technology. Results and discussion: in assessment the risk of DM type 2, distinguished groups of patients with a low risk of developing DM type 2 included 310 (80%) participants, and a high group of risk of DM type 2- 79 (20%). The level of the biomarker FABP4 significantly prevailed in the group with high risk of the developing DM type 2 in comparison with the low group of risk. A positive direct correlation (r-0.59) was found, statistically significant, indicated the level of the FABP4 marker is increasing with an increase the risk of developing DM type 2. Conclusions: The results of the research identified groups of patients with different risk of developing DM type 2, detected an increased level of the FABP4 biomarker in the high group of risk of DM type 2, and established the interrelation between the increased level of this biomarker of endothelial dysfunction FABP4 and the increased risk of developing DM type 2.

Breast cancer is a malignant tumor of glandular breast tissue. 10-12% out of the 10 million newly reported cases of malignant diseases worldwide are the breast cancer. There are differences in the incidence of breast cancer among various ethnic groups. This is associated with the traditions and lifestyle of different peoples. According to the literature, there are studies comparing the incidence of breast cancer among different ethnic groups in the US and many other countries. Undeservedly insufficient attention is given to the problem of ethnic characteristics of breast cancer in Kazakhstan. Currently, the molecular genetic classification of breast cancer, which was proposed by C. M. Perou et al. in 2000, is used to determine the optimal treatment tactic. This classification is based on the allocation of a cluster of 465 genes that are divided into four expression classes corresponding to luminal A, luminal B, HER2/neu positive and triple negative breast cancer by cluster analysis. Each of these types is characterized by its specific tumor response to ongoing treatment, and the outcome of the disease. This classification remains relevant until now. The "gold standard" for conducting immunohistochemical research for the selection of adequate tactics for patients is the expression determination of receptors for estrogen, progesterone, HER2/neu, Ki67, and in cases of triple negative cancer - CK5/6 and EGFR1 or vimentin, additionally.

In recent years, along with the overall increase in injuries, there has been an increase in the incidence of maxillofacial injuries, so the problem of injuries to the maxillofacial area continues to be one of the most urgent in maxillofacial surgery. Despite the variety of methods for treating fractures of the lower jaw, incorrect fusion of bone fragments often occurs due to insufficient fixation, leading to deformation of the face, dysfunction of the dentoalveolar system. The article compares the treatment of patients with mandibular fractures with individual tires with hooked loops, rubber thrust and mandibular-maxillary fixation.

It is known that zinc, contained in в-cells of the pancreas, takes an important part in the formation of its deposited storage form in the cell, due to which not all of the cell-synthesized hormone, but only a certain amount of it, enters the blood, regulating carbohydrate metabolism and providing maintenance of blood glucose level at a constant level. It is also known that there are zinc-binding diabetogenic substances that, when ingested, bind to zinc of в-cells, forming toxic complexes, leading to destruction and cell death within 15-30 minutes. A total of 18 such substances are known, and 17 of them refer to derivatives of 8-hydroxyquinoline, some of whose representatives are components of 12 drugs (in 1970 there were 2 of them). It is also known that the preliminary introduction of the amino acid cysteine completely prevents the development of diabetes caused by zinc-binding diabetogenic substances. Presumably, this is justified by its ability to block zinc in the doses used for 24-36 h, preventing it from interacting with zinc-binding diabetogenic substances. Authors using sensitive and strictly specific methods have established that indeed, cysteine blocks islet zinc, preventing its interaction with zinc-binding diabetogenic substances. The authors believe that the blocked zinc atoms are fixed between the sulfur atom that is part of the SH group in the cysteine molecule and the oxygen atom of the carboxyl group, or between the sulfur atom and the nitrogen atom of the amino group of the cysteine molecule, as is also the case with the interaction of zinc with zinc-binding diabetogenic substances, where chelates with zinc are formed only as a result of fixing them between these atoms.

In this original article the analysis of interaction between kidneys and paranephral tissue with synthetic implants made of polyester mesh, macroporous partially absorbable light mesh UltraPro and own peritoneal-fascial flap in nephropexy, by conducting an experimental study on laboratory animals. The results were obtained on the basis of the assessment of macroscopic and histological picture, also using the statistical analysis of the morphometric picture of the kidney sections and paranephral fiber.The results obtained in the study expanded idea of the influence of the implant in the kidney tissue and perirenal fat, justifying the possible reactive changes parenchymal kidney and connective components in interaction with polyester mesh and nephropexy using own peritoneum - fascial flap. The findings substantiate the possibility of carrying out clinical trials to study partiallyeasy absorbable mesh UltraPro.

A prototype of a new biological implant - extracellular bovine-derived peritoneum matrix for abdominal wall reconstruction was developed and obtained. The aim was to study the biomechanical properties of the extracellular bovine-derived peritoneum matrix in comparison with the «Permacol» biological implant at the preoperative stage and after implantation (up to 180 days) in the experiment. The strength characteristics for elongation and rupture of the materials were studied experimentally. Based on the results of testing the samples, the extracellular bovine-derived peritoneum matrix demonstrates high mechanical strength, exceeding in 2 times than the comparison material "Permacol", mainly due to the elasticity. In the postoperative period, a multiple increase in the tensile strength is observed, both in the group with the extracellular bovine-derived peritoneum matrix, and in the comparison group where the acellular dermal collagen "Permacol" was used, while achieving an average values of absolute maximum of 14.5N and 15.9N respectively, without statistically significant differences, both at each observation period and totally in the experiment.

Study of blood plasma tesiogramms was performed in 51 patients with locally advanced breast cancer who received three regimens of neoadjuvant chemotherapy. The control sample consisted of 10 practically healthy women. All patients are divided into 3 groups - 2 studied, one - control. In the control group, patients received 4 courses of neoadjuvant chemotherapy according to the AC-protocol (doxorubicin 50 mg/m², cyclophosphamide 500 mg/m²). The study group 1^st received 4 courses of chemotherapy according to the protocol AC+Arglabin (Arglabin 370 mg/m² 7 days), the study group 2^nd - 4 courses of Arglabin. Three morphotypes of tesiogramms in patients with breast cancer before treatment have been described. There were revealed specific signs of a change in the tesiographic picture of blood in patients who received different regimens of chemotherapy. It has been shown that arglabin, both in mono regimen and in combination with AC, promotes a rise in the blood of hydrophobic components, which may be indirectly indicative of increased cytolysis of tumor cells in the body, which correlates with the clinical efficacy of chemotherapy.

Cerebral stroke is one of the main common causes of death and disability of the population of Kazakhstan, including in the Karaganda region. According to official statistics, more than 40,000 strokes occur annually in the Republic of Kazakhstan. Every year 15.5 thousand Kazakhstan people die from a stroke. In paper the application of the register method and its effectiveness in the study of cerebral stroke as a primary agent is shown.

At the Department of Clinical Pharmacology and Evidence Medicine, the KSMU has introduced an innovative program (RBL) for including students in professional research activities. In order to develop the scientific potential of students, we use the method of scientific projects. The essence of this method is to create an educational situation that simulates the independent research work of students within the framework of a given topic. The teacher monitors the performance of the work and, if necessary, adjusts the work of the students. The main goal of the project method is the formation of the experience of independent research.

Ne of the urgent problems currently faced by the domestic health system that is providing staff with the necessary level of professional competence, including knowledge and skills in the field of medical care. As one of the key tasks is development of complex measures to improve clinical training of health personnel through the introduction of mentoring. In this review, the role of the mentor in medical education as a way of forming the future specialists of clinical thinking and practical skills.

To form the skill of scientific research among students at the Department of general pharmacology have developed several forms of performing RBL in the framework of individual work in the form of a project, a resume and an essay. The structure of the performing task and the requirements for the design of scientific research work contained in the methodical recommendations of students individual work. Evaluation sheets of students individual work on writing a project, a resume and an essay and feedback questionnaire were developed. After preparation of scientific research work, students were underwent questionnaire survey in the framework of feedback. The questionnaire showed interest and a conscious desire of students to obtain necessary knowledge on pharmacology. Most of the students coped with the task, but some faced the problem, due to the inability to briefly formulate the main theses and justify them, as well as in the conclusions, summarizing the study, some had difficulties in correctly providing information. Thus, the use of RBL in the performing students individual work will allow: to develop practical skills and abilities; actively use the literature review of scientific literature in preparation for classes on the SIWT and SIW.

In the article features of introduction of active methods of teaching in the educational process at the department of nutritional and general hygiene in the discipline of "food hygiene" are considered. The use of active teaching methods in the learning process contributes to the formation of students' skills of working in a team, the ability to make decisions and be responsible for them in various situations close to the professional, build the right relations with colleagues, develop the skills of research activities.

The article deals with the formation of clinical skills in the practical activities of students in the «Phthisiology», namely: the goals and objectives of clinical teaching, unlike conventional academic training, basic methods and elements of training and characteristics of training, advice to clinical teachers. Attention is paid to the organization of the educational process and the correct use of audio-visual aids, an analysis of various combinations of practical exercises with the inclusion of modern technology, interactive teaching methods. It is summarized that such non-standardized approaches to teaching provide clinicians with the necessary knowledge and skills for shorter periods, with fewer patients involved, saves money, allows them to increase the motivation of learners for learning, contribute to the formation of their clinical thinking, and, thereby, create conditions for the training of competent doctors.