Қояндардағы феморальды ақау үлгісінде rhBMP-2 және сүйек аллографын пайдаланған кезде остеорегенерацияның тиімділігін бағалау

Зерттеудің мақсаты. Марбург жүйесі бойынша дайындалған сүйек Банкінің сүйек аллографын rhBMP2-мен бірге қояндағы феморальды ақау моделінде қолданған кезде сүйек тінінің регенерация процестеріне гистологиялық және гистоморфометриялық бағалау жүргізу.

Материалдар мен әдістер. Бұл зерттеуде 2 топ құрылды, олардың әрқайсысында диаметрі 5 мм ақау пайда болған 24 субъект (қоян), фемордың дистальды метафизінде. Бірінші топта ақау rhBMP-2-мен бірге сүйек аллографымен толтырылды, екінші топта ақау қосымша препараттарсыз сүйек аллографымен толтырылды. Әрі қарай алынған деректерді гистологиялық және статистикалық өңдеу жүргізілді.

Нәтижелер. 14 тәулікте AG+rhBMP-2 тобында жаңадан пайда болған сүйек тіндері кортикальды пластинаның жалпы ақау аймағының 34.75±5.67% құрады. 30 тәулікте AG+rhbmp-2 тобында кортикальды пластинка ақауының жабылуы 79.12±14.32% құрады, жаңадан пайда болған сүйек ұлпасы кортикальды пластинаның ұзындығының 80.75% және қалыңдығының 71.37% жабылды. 60-шы күні AG+rhBMP-2 тобында жаңадан пайда болған сүйек тіндері кортикальды пластинаның жалпы ақау аймағын 64.50±27.73%, ұзындығы 62% және қалыңдығы 65.25%-ға жауып тастады.

Қорытынды. Осы зерттеудің нәтижелері бойынша сүйек аллографын rhBMP-2-мен бірге сүйек тінінің регенерациясының кеш кезеңдерінде қолдану қанағаттанарлықсыз нәтижелерге әкелетінін көруге болады, бұл алынған мәліметтердің жоғары гетерогенділігі түрінде көрінеді, олардың арасында, көп жағдайда, ақаудың жаңадан пайда болған сүйек тінімен жабылуы жеткіліксіз.

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