Современный подход к лечению сахарного диабета 2 типа, осложненного синдромом диабетической стопы

Гипергликемия, характерная для сахарного диабета, способствует производству выработки агентов окислительного стресса, которые вызывают нарушение иммунной функции и развитие хронического воспалительного процесса. Эти факторы лежат в основе развития поздних осложнений сахарного диабета, таких как ишемическая болезнь сердца, нестабильная стенокардия, инфаркт миокарда, периферическая микроангиопатия и другие сочлененные заболевания, которые ухудшают прогноз при синдроме диабетической стопы. Воспалительные процессы и нарушения деятельности иммунной системы способствуют дисбалансу тканевого гомеостаза, ассоциируются с появлением хронических язв и потребностью в ампутации нижних конечностей. Последствия хронических ран создают неблагоприятную реальность инвалидности и душевного стресса для пациентов. Как пациенты, так и медицинский персонал, несомненно, получат выгоду от более глубокого понимания патогенеза и патофизиологии различных незаживающих язв. Новые знания приобретены путем сравнения сходства между хроническими ранами различной природы с их различиями от острых ран.

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