ТЕМІР МЕТАБОЛИЗМІ ТУРАЛЫ ҚАЗІРГІ КЕЗДЕГІ ТҮСІНІКТЕР

Гепсидинді белсендіруге әкелетін белгі беру механизмдерін жан-жақты зерделеу осы зерттеудің перспективалы бағыты болып табылады. Темірдің жүйелік және торшалық метаболизмі арасындағы регуляторлық өзара байланысты анықтау мен зерттеу маңызды бағыт болып бағаланады. Сол сияқты торшаішілік органелдер мембаранасы арқылы темір тасымалының тетіктері соңына дейін зерттелмеген. Бұл бағыттағы зерттеулер биологиялық қана емес, медициналық та маңызға ие. Мысалы, гепсидин-ферропортин осі дәрілер әзірлеу үшін тартымды нысана ретінде бағаланады. IRP1 және IRP2 темір метаболизмін реттеуге ғана қатыспайды, сонымен қатар қатерлі ісіктің даму механизмінде дербес роль атқарады.

темір, метаболизм, гепсидин, синтез, трансферрин, железо

1. Левина А. А. Гепсидин как регулятор гомеостаза железа /А. А. Левина, Т. В. Казюкова, Н. В. Цветаева //Педиатрия. - 2008. - V. 87 (1). - P. 67-74.

2. Маянский Н. А. Гепцидин: основной регулятор обмена железа и новый диагностический маркер /Н. А. Маянский, Е. Л. Семикина //Вопр. диагностики в педиатрии. -2009. - V. 1. - P. 18-23.

3. Anderson G. J. Iron absorption and metabolism /G. J. Anderson, D. M. Frazer, G. D. McLaren //Curr. Opin. Gastroenterol. - 2009. - V. 25 (2). - P. 129-135.

4. Arosio P. Ferritin, cellular iron storage and regulation /P. Arosio, L. Elia, M. Poli //UBMB Life. - 2017. - V. 69 (6). - P. 414-422.

5. Arosio P. Ferritins: a family of molecules for iron storage, antioxidation and more /P. Arosio, R. Ingrassia, P. Cavadini //Biochim. Biophys. Acta. - 2009. - V. 1790. - P. 589-599.

6. Babitt J. L. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression /J. L. Babitt, F. W. Huang, D. M. Wrighting //Nat. Genet. - 2006. - V. 38. - P. 531-539.

7. Bou-Abdallah F. Reductive Mobilization of Iron from Intact Ferritin: Mechanisms and Physiological Implication /F. Bou-Abdallah, J. J. Paliakkara, G. Melman //Pharmaceuticals (Basel). -2018. - V. 11 (4). - P. 120.

8. De Domenico I. Ferroportin-mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome /I. De Domenico, M. B. Vaughn, L. Li //EMBO J. - 2006. - V. 25. - P. 5396-5404.

9. Finberg K. E. Regulation of systemic iron homeostasis //Curr. Opin. Hematol. - 2013. - V. 20 (3). - P. 208-214.

10. Galaris D. Oxidative stress and iron homeostasis: mechanistic and health aspects /D. Galaris, K. Pantopoulos //Crit. Rev. Clin. Lab. Sci. - 2008. - V. 45. - P. 1-23.

11. Gunshin H. Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver /H. Gunshin, Y. Fujiwara, A. O. Custodio //J. Clin. Invest. - 2005. - V. 115. - P. 1258-1266.

12. Hentze M. W. Two to tango: regulation of mammalian iron metabolism /M. W. Hentze, M. U. Muckenthaler, B. Galy //Cell. - 2010. - V. 142. - P. 24-38.

13. Johnson D. C. Structure, function, and formation of biological iron-sulfur clusters /D. C. Johnson, D. R. Dean, A. D. Smith //Annu. Rev. Biochem. - 2005. - V. 74. - P. 247-281.

14. Kato J. Iron/IRP-1-dependent regulation of mRNA expression for transferrin receptor, DMT1 and ferritin during human erythroid differentiation /J. Kato, M. Kobune, S. Ohkubo //Exp. Hematol. - 2007. - V. 35. - P. 879-887.

15. Keel S. B. A heme export protein is required for red blood cell differentiation and iron homeostasis /S. B. Keel, R. T. Doty, Z. Yang // Science. - 2008. - V. 319. - P. 825-828.

16. Kidane T. Z. Release of iron from ferritin requires lysosomal activity /T. Z. Kidane, E. Sauble, M. C. Linder //Am. J. Physiol. Cell Physiol. -2006. - V. 291. - C445-C455.

17. La A. Mobilization of iron from ferritin: New steps and details /A. La, T. Nguyen, K. Tran. - Metallomics. - 2018. - V. 10. - P. 154-168.

18. Lee P. L. Regulation of hepcidin and iron-overload disease /P. L. Lee, E. Beutler // Annu. Rev. Pathol. - 2009. - V. 4. - P. 489-515.

19. Lill R. Function and biogenesis of iron-sulphur proteins //Nature. - 2009. - V. 460. - P. 831-838.

20. Linder M. C. Mobilization of Stored Iron in Mammals: A Review //Nutrients. - 2013. - V. 5 (10). - P. 4022-4050.

21. Ma J. Fe2+ binds iron responsive element-RNA, selectively changing protein-binding affinities and regulating mRNA repression and activation /J. Ma, S. Haldar, M. A. Khan //Proc. Natl. Acad. Sci. U S A. - 2011. - V. 109. - P. 8417-8422.

22. Nemeth E. The role of hepcidin in iron metabolism /E. Nemeth, T. Ganz //Acta Haematol. - 2009. - V. 122. - P. 78-86.

23. Ohgami R. S. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells /R. S. Ohgami, D. R. Campagna, E. L. Greer //Nat. Genet. - 2005. - V. 37. - P. 1264-1269.

24. Olsson K. S. Comment to: Hepcidin: from discovery to differential diagnosis /K. S. Olsson, A. Norrby //Haematologica. - 2008. - V. 93. - P. 90-97.

25. Pak M. Suppression of hepcidin during anemia requires erythropoietic activity /M. Pak, M. A. Lopez, V. Gabayan //Blood. - 2006. - V. 108. - P. 3730-3735.

26. Pantopoulos K. Iron metabolism and the IRE/IRP regulatory system: an update //Ann. NY Acad. Sci. - 2004. - V. 1012. - P. 1-13.

27. Paradkar P. N. Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2 /P. N. Paradkar, K. B. Zumbrennen, B. H. Paw //Mol. Cell. Biol. -2009. - V. 29. - P. 1007-1016.

28. Piccinelli P. Evolution of the iron-responsive element /P. Piccinelli, T. Samuelsson //RNA. - 2007. - V. 13. - P. 952-966.

29. Ponka P. Function and regulation of transferrin and ferritin /P. Ponka, C. Beaumont, D. R. Richardson //Semin. Hematol. - 1998. - V. 35. - P. 35-54.

30. Recalcati S. Molecular regulation of cellular iron balance //S. Recalcati, E. Gammella, P. Buratti //IUBMB Life. - 2017. - V. 69 (6). - P. 389-398.

31. Richardson D. R. Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol /D. R. Richardson, D. J. Lane, E. M. Becker //Proc. Natl. Acad. Sci. U.S.A. - 2010. - V. 107. - P. 1077510782.

32. Ryter S. W. The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro and antioxidant properties /S. W. Ryter, R. M. Tyrrell //Free Radical. Biol. Med. - 2000. - V. 28. - P. 289-309.

33. Schmidt P. J. Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation //J. Biol. Chem. - 2015. - V. 290 (31). - P. 18975-18983.

34. Shaw G. C. Mitoferrin is essential for erythroid iron assimilation /G. C. Shaw, J. J. Cope, L. Li. - Nature. - 2006. - V. 440. - P. 96100.

35. Shi H. A cytosolic iron chaperone that delivers iron to ferritin /H. Shi, K. Z. Bencze, T. L. Stemmler //Science.- 2008.-V.320.-P.1207-1210.

36. Som D. Babitt Overview of Iron Metabolism in Health and Disease / D. Som, L. Jodie // Hemodial Int. - 2017. - V. 21. - S6-S20.

37. Stys A. The role of iron regulatory proteins in the control of iron metabolism in mammals /A. Stys, R. R. Starzynski, P. Lipinski // Journal of Biotechnology, Computational Biology and Bionanotechnology. - 2011. - V. 92 (1). - P. 66-75.

38. Verga Falzacappa M. V. STAT-3 mediates hepatic hepcidin expression and its inflammatory stimulation /M. V. Verga Falzacappa, M. V. Spasic, R. Kessler //Blood. - 2007. - V. 109. -P. 353-358.

39. Volz K. The functional duality of iron regulatory protein 1 //Curr. Opin. Struct. Biol. -2008. - V. 18. - P. 106-111.

40. Wallander M. L. Molecular control of vertebrate iron homeostasis by iron regulatory proteins /M. L. Wallander, E. A. Leibold, R. S. Eisenstein //Biochim. Biophys. Acta. - 2006. - V. 1763. - P. 668-689.

41. Wang J. Regulation of cellular iron metabolism /J. Wang, K. Pantopoulos Biochem J. -2011. - V. 434. - P. 365-381.

42. Wrighting D. M. Interleukin-6 induces hepcidin expression through STAT3 /D. M. Wrighting, N. C. Andrews //Blood. - 2006. - V. 108. - P. 3204-3209.

43. Ye H. Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease /H. Ye, T. A. Rouault //Biochemistry. - 2010. - V. 49. -P. 4945-4956.

44. Yeh K. Y. Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium /K. Y. Yeh, M. Yeh, L. Mims //Am. J. Physiol. Gastrointest. Liver Physiol. - 2009. - V. 296. - G55-G65.

45. Zhang D. L. The physiological functions of iron regulatory proteins in iron homeostasis -an update /D. L. Zhang, M. C. Ghosh, T. A. Rouault //Front Pharmacol. - 2014. - P. 5-124.

46. Zhang Y. Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit /Y. Zhang, M. Mikhael, D. Xu //Antioxid. Redox Signaling. - 2010. - V. 13. - P. 999-1009.

47. Zhi Dong Zh. Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases / Zh. Zhi Dong, T. Eng-King //Mol. Neurodegener. - 2017. - V. 12. - P. 75. doi: 10.1186/s13024-017-0218-4.