The possibilities of adverse pregnancy outcomes predicting based on laboratory markers of reproductive losses

Aim of the study. To evaluate the relationship of prognostic laboratory markers of habitual miscarriage with histological pregnancy outcomes.
Materials and methods. A retrospective study was conducted with an analysis of the histological outcomes of pregnancy, and their relationship with the main prognostic laboratory markers. The study included 56 women of reproductive age who sought medical help in a hospital due to reproductive loss up to 12 weeks of pregnancy with a history of two or more adverse pregnancy outcomes. A statistical analysis of the relationship between histological pregnancy outcomes and prognostic laboratory markers of reproductive loss was carried out.
Results and discussion. In our study, we found a statistically significant difference between group 1 and group 2. Thus, the quartile ranges of IL-6 were 5,730 – 8,840 and 3,540 – 6,910, respectively, which can serve as a prerequisite for the formation of reference values for predicting inflammatory factors at the pre-gravidar stage. Significant statistical differences between groups 1 and 2 in terms of TM were also obtained. Thus, the quartile ranges were 5,430 – 6,510 in group 1 and 7,120 – 9,030 in group 2, which shows a significant correlation between laboratory markers of analysis and the results of histological studies in the form of hemorrhagic changes.
Conclusions. According to the analysis of histological outcomes of pregnancy up to 12 weeks in the population of women in Kazakhstan, the main causes are inflammatory and hemorrhagic disorders. As the most significant prognostic laboratory criteria, as a result of the study, IL-6 can be identified as a predisposing factor for the presence of inflammatory causes of reproductive losses and thrombomodulin, as the gold standard for identifying coagulation and hemorrhagic causes of habitual miscarriage.

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