Хориоллантоикалық мембранасын эндометриялық қабылдау маркерлерін анықтауға арналған эксперименттік модель ретінде қолдану

Мақалада эндометрийдiң рецептивтілік пен ангиогенездің маркерлері мен механизмдерін зерттеу үшін хориоллантоикалық мембрананы (САМ) қолдана отырып, зерттеу нәтижелерін жалпылауға бағытталған мақалаларға шолу жасалады. Бұларды қарастыру зерттеулер қан тамырларының дамуына және эндометрияның сезімталдығына қатысатын күрделі реттеуші желілерді нақтылайды. Ангиогенездің қырсырын және эндометрияның сезімталдығын түсіну репродуктивті медицина мен бедеулікті емдеуде өте маңызды. Хориоаллантоикалық мембрана (CAM) және оның аналогтары, стромадан алынған ангиогендік модель (CAM) осындай зерттеулер үшін құнды платформалар ұсынады. CAM көмегімен тиісті зерттеулерді анықтау үшін ғылыми әдебиеттер базасында жан-жақты іздеу жүргізілді. CAM көмегімен жүргізілген зерттеулер тамырлардың дамуына байланысты құрылымдық өзгерістерге жарық түсіру арқылы эндометрияның сезімталдық маркерлері туралы түсінік берді. Сол сияқты, CAM көмегімен жүргізілген зерттеулер пиноподиялар және эндометрияның сезімталдығын көрсететін басқа маркерлер туралы құнды ақпарат берді, бұл репродуктивті медицинада ықтимал клиникалық қолдануды көрсетеді. Біріктірілген бұл зерттеулер эндометрияны реттеудің жасушалық және молекулалық механизмдерін тереңірек түсінуге ықпал етеді. Олар эндометриялық ангиогенезді индукциялау және оның сезімталдығын модуляциялаудағы өсу факторларын, цитокиндерді және сигнал беру жолдарын қоса алғанда, әртүрлі факторлардың рөлін атап көрсетеді. Мұндай тұжырымдар репродуктивті медицинада жаңа диагностикалық және емдік стратегияларды әзірлеуге негіз бола алады.

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