medecolМедицина и экологияMedicine and ecology2305-60452305-6053Карагандинский медицинский университет10.59598/ME-2305-6045-2024-113-4-43-52medecol-798Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSПрименение хориоаллантоисной мембраны как экспериментальной модели для изучения маркеров рецептивности эндометрияThe use of the chorioallantoic membrane as an experimental model for studying markers of endometrial receptivityМусаеповаА. Б.MussayepovaA. B.

Асель Бериковна Мусаепова – докторант 1 года обучения

100008, г. Караганда, ул. Гоголя, 40

Assel Berikovna Mussayepova – doctoral student of 1st year of study

100008, Karaganda, Gogol street, 40

info@qmu.kzТурдыбековаЯ. Г.TurdybekovaY. G.

100008, г. Караганда, ул. Гоголя, 40

100008, Karaganda, Gogol street, 40

info@qmu.kzРахимоваБ. Б.RakhimovaB. B.

100008, г. Караганда, ул. Гоголя, 40

100008, Karaganda, Gogol street, 40

info@qmu.kzКопобаеваИ. Л.KopobaevaI. L.

100008, г. Караганда, ул. Гоголя, 40

100008, Karaganda, Gogol street, 40

info@qmu.kzКафедра акушерства, гинекологии и перинатологии НАО «Карагандинский медицинский университет»КазахстанDepartment of Obstetrics, Gynecology and Perinatology of Non-Commercial Joint Stock Company «Karaganda medical university»KazakhstanКафедра акушерства, гинекологии и перинатологии НАО «Карагандинский медицинский университет»КазахстанDepartment of Biomedicine Non-Commercial Joint Stock Company of Non-Commercial Joint Stock Company «Karaganda medical university»KazakhstanКафедра биомедицины НАО «Карагандинский медицинский университет»КазахстанDepartment of Obstetrics, Gynecology and Perinatology of Non-Commercial Joint Stock Company «Karaganda medical university»Kazakhstan202421012025044352Copyright © Мусаепова А.Б., Турдыбекова Я.Г., Рахимова Б.Б., Копобаева И.Л., 20242024Мусаепова А.Б., Турдыбекова Я.Г., Рахимова Б.Б., Копобаева И.Л.Mussayepova A.B., Turdybekova Y.G., Rakhimova B.B., Kopobaeva I.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medecol.qmu.kz/jour/article/view/798

В статье представлен обзор статей, направленный на обобщение результатов исследований с использованием хориоллантоисной мембраны (САМ) для изучения маркеров и механизмов рецептивности эндометрия и ангиогенеза. Рассмотрение этих исследования в совокупности проясняет сложные регуляторные сети, участвующие в развитии сосудов и восприимчивости эндометрия. Понимание тонкостей ангиогенеза и восприимчивости эндометрия имеет решающее значение в репродуктивной медицине и лечении бесплодия. Хориоаллантоисная мембрана (CAM) и ее аналоги, ангиогенная модель, полученная из стромы (CAM), предлагают ценные платформы для таких исследований. Был проведен всесторонний поиск в базах данных научной литературы для выявления соответствующих исследований с использованием CAM. Исследования с использованием CAM позволили получить представление о маркерах восприимчивости эндометрия, пролив свет на структурные изменения, связанные с развитием сосудов. Аналогичным образом, исследования с использованием CAM позволили получить ценную информацию о пиноподиях и других маркерах, указывающих на восприимчивость эндометрия, что указывает на потенциальное клиническое применение в репродуктивной медицине. В совокупности эти исследования способствуют более глубокому пониманию клеточных и молекулярных механизмов регуляции эндометрия. Они подчеркивают роль различных факторов, включая факторы роста, цитокины и сигнальные пути, в индуцировании ангиогенеза эндометрия и модулировании его восприимчивости. Такие выводы могут послужить основой для разработки новых диагностических и терапевтических стратегий в репродуктивной медицине.

The article presents a review of articles aimed at summarizing the results of studies using the choriollantoic membrane (СAM) to study markers and mechanisms of endometrial receptivity and angiogenesis. Considering these studies together clarifies the complex regulatory networks involved in vascular development and endometrial susceptibility. Understanding the intricacies of angiogenesis and endometrial susceptibility is crucial in reproductive medicine and infertility treatment. The chorioallantoic membrane (CAM) and its analogues, the angiogenic model derived from stroma (CAM), offer valuable platforms for such research. A comprehensive search of scientific literature databases was conducted to identify relevant studies using CAM. Studies using CAM have provided insight into markers of endometrial susceptibility, shedding light on structural changes associated with vascular development. Similarly, studies using CAM have provided valuable information on pinopods and other markers indicating endometrial susceptibility, indicating potential clinical applications in reproductive medicine. Together, these studies contribute to a deeper understanding of the cellular and molecular mechanisms of endometrial regulation. They emphasize the role of various factors, including growth factors, cytokines, and signaling pathways, in inducing endometrial angiogenesis and modulating its susceptibility. Such findings can serve as a basis for the development of new diagnostic and therapeutic strategies in reproductive medicine.

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The authors declare that there are no conflicts of interest present.