The use of the chorioallantoic membrane as an experimental model for studying markers of endometrial receptivity

The article presents a review of articles aimed at summarizing the results of studies using the choriollantoic membrane (СAM) to study markers and mechanisms of endometrial receptivity and angiogenesis. Considering these studies together clarifies the complex regulatory networks involved in vascular development and endometrial susceptibility. Understanding the intricacies of angiogenesis and endometrial susceptibility is crucial in reproductive medicine and infertility treatment. The chorioallantoic membrane (CAM) and its analogues, the angiogenic model derived from stroma (CAM), offer valuable platforms for such research. A comprehensive search of scientific literature databases was conducted to identify relevant studies using CAM. Studies using CAM have provided insight into markers of endometrial susceptibility, shedding light on structural changes associated with vascular development. Similarly, studies using CAM have provided valuable information on pinopods and other markers indicating endometrial susceptibility, indicating potential clinical applications in reproductive medicine. Together, these studies contribute to a deeper understanding of the cellular and molecular mechanisms of endometrial regulation. They emphasize the role of various factors, including growth factors, cytokines, and signaling pathways, in inducing endometrial angiogenesis and modulating its susceptibility. Such findings can serve as a basis for the development of new diagnostic and therapeutic strategies in reproductive medicine.

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