MOLECULAR CANCER MARKERS WI T H CHRON I C INTOXI C ATION AND VIRAL INFECTION

Pathogenesis of the connection infection, intoxication and cancer is the interesting and actual problem for research. The aim of the study was to investigate the level of cancer biomarkers in HIV-infected patients with a background of narcotic drugs parenteral forms use and in HIV-infected patients without aggravating background. The authors analyzed the serum from 30 HIV-positive injecting drug users, 30 HIV-positive patients without drug addiction. The control group consisted of 30 healthy people, negative in screening for HIV-infection, and the comparison group consisted of 23 patients with drug dependence. The authors used xMap method on Bioplex 3D with set Cancer Biomarcers panel: sHER/2, sEGFR, sIL-6Ra, FGF, sVEGFR-2, PECAM1, PDGF AB/BB, G-SCF, sTIE2, SCF, sVEGFR -1, osteopantin. The authors of the article revealed the increased levels of sHER/2, sEGRf, sIL-6RA, sVEGfr2, PECAM1, sTIE2 in all HIV-infected patients. SCF and FGF markers were increased only in injecting drug users (HIV+/HIV-). The drug addicts with HIV had the increased level of inflammatory markers sIL-6RA, PECAM 1, osteopantin and the level of HER-2. Thus, the study of carcinogenesis biomarkers has its own peculiarities in HIV-positive patients, including with complications of drug addiction.

cancer biomarkers, cancer, HIV, drug addiction

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