Features of the bioelement status of children and adolescents living in oil and gas regions

In the context of intensive development of gas industry, environmental safety issues are becoming increasingly important. The high rates of gas production and the growth of its chemical processing have turned gas industry enterprises into a powerful source of environmental pollution, which poses a real threat to public health, contributes to an increase in morbidity and ecologically caused pathological conditions. The aim of the study was to study the mineralization of bone tissue in children with different levels of physical development, to determine the options for physical development, which could be the criteria for classifying children into groups at increased risk of osteopenia and indications for in-depth laboratory and instrumental examination. 519 adolescents aged 14-17 years were examined, of which 349 lived in the oil and gas region and 170 were the control group. Anthropometry and biochemical blood examination were performed to determine the parameters of bone metabolism (osteocalcin, calcium, phosphorus, PTH, P1NP, bCrosslaps). As a result, it was revealed that the physical development and indicators of bone metabolism in children of the oil and gas region are lower than in the control group. The indicator characterizing the ratio of P1NP/b-Crosslaps processes, bone remodeling was almost 2 times lower in children of the main group (p=0.039), which may indicate a relative prevalence of resorptive processes over synthetic in bone tissue in children of the oil and gas region.

1. Carson V, Tremblay MS, Chastin SFM. Cross-sectional associations between sleep duration, sedentary time, physical activity and adiposity indicators among Canadian preschool children using compositional analyses. BMC PublicHeal. 2017;17(Suppl 5):848.

2. Poitras VJ, Gray CE, Janssen X, Aubert S, Carson V, Faulkner G, et al. Systematic review of the relationships between sedentary behavior and health indicators in the early years (aged 0-4 years) BMC Public Heal. 2017;17(868):65–89.

3. Chaput JP, Colley RC, Aubert S, Carson V, Janssen I, Roberts KC, et al. Proportion of preschool-aged children meeting the Canadian 24-hour movement guidelines and associations with adiposity: results from the Canadian health measures survey. BMC PublicHeal. 2017;17(Suppl 5):829.

4. Kuzik N, Poitras VJ, Tremblay MS, Lee EY, Hunter S, Carson V. Systematic review of the relationships between combinations of movement behaviors and health indicators in the early years (0 to 4 years) BMC Public Heal. 2017;17(Suppl 5):849.

5. Carson V, Hunter S, Kuzik N, Gray CE, Poitras VJ, Chaput JP, et al. Systematic review of sedentary behaviour and health indicators in school-aged children and youth: an update. ApplPhysiolNutrMetab. 2016;41(6 Suppl 3):S240–S265.

6. World Health Organization . WHO guidelines on physical activity, sedentary behaviour and sleep for children under 5 years of age. Geneva, Switzerland: World Health Organization; 2019.

7. Zaharova I. N., Korovina N. A., Dmitrieva Ju. A. Rol' metabolitov vitamina D pri rahite u detej // Pediatrija: zhurnal im. G.N. Speranskogo. – 2010. – T. 89, № 3. – S. 68–73. 2.

8. Acar S., DemirK., Shi Y. Genetic sauses of rickets // Clin. Res. Pediatr. Endocrinol. – 2017. – Vol. 9, Suppl. 2. – Pp. 88–105. 5. Holick M.F., Grant W.B. Vitamin D status and ill health. LancetDiabetesEndocrinol. – 2014. – Vol. 2, No. 4. – Pp. 273–274.

9. Saxton RA, Sabatini DM (2017) mTOR signaling in growth, Metabolism, and Disease. Cell 168(6):960–976

10. Kljuchnikov S.O., Kravchuk D.A., Ogannisjan M.G. Osteoporoz u detej i ego aktual'nost' dlja detskoj sportivnoj mediciny. Rossijskij vestnik perinatologii i pediatrii. 2017;62 (3):112– 120. doi: 10.21508/1027-4065-2017-62-3-112-120.

11. Chen J, Long F (2018) mTOR signaling in skeletal development and disease. BoneRes 6:1

12. Williamson AA, Mindell JA, Hiscock H, JonQuach J. Sleep problem trajectories and cumulative socio-ecological risks: birth to schoolage. J Pediatr. 2019;215:229–237.

13. Reilly JJ, Hughes AR, Janssen X, et al. GRADE-ADOLOPMENT process to develop 24-hour movement behavior recommendations and physical activity guidelines for the under 5s in the UK, 2019. J PhysActHealth. 2020;17(1):101–108.

14. Mal'cev S.V., Mansurova G.Sh. Snizhenie mineral'noj plotnosti kosti u detej i podrostkov: prichiny, chastota razvitija, lechenie. Voprosy sovremennoj pediatrii. 2015;14(5):573–578. doi: 10.15690/vsp.v14i5.1442.

15. Gladkova E.V., Fedonnikov A.S., Careva E.E., Moiseev E.P., Karjakina E.V., Persova E.A. i dr. Sistema laboratorno-instrumental'noj ocenki sostojanija metabolizma kostnoj tkani. Fundamental'nye issledovanija. 2015; (1—5): 925-8.

16. Tyrtova D.A., Jerman M.V., Tyrtova L.V., Ivashikina T.M. Osteoporoz v detskom i podrostkovom vozraste: sostojanie problemy. Vestnik Sankt-Peterburgskogo universiteta. 2009;11 (2):164–173.

17. Murata K, Fang C, Terao C, Giannopoulou EG, Lee YJ, Lee MJ, Mun SH, Bae S, Qiao Y, Yuan R, Furu M, Ito H, Ohmura K, Matsuda S, Mimori T, Matsuda F, Park-Min KH, Ivashkiv LB (2017) Hypoxia-sensitive COMMD1 integrates signaling and cellular metabolism in human macrophages and suppresses osteoclastogenesis. Immunity 47(1):66–79 e.

18. Karner CM, Long F (2018) Glucose metabolism in bone. Bone 115:2–7.

19. Okely AD, Ghersi D, Hesketh KD, Santos R, Loughran SP, Cliff DP, et al. A collaborative approach to adopting/adapting guidelines - the Australian 24-hour movement guidelines for the early years (birth to 5 years): an integration of physical activity, sedentary behavior, and sleep. BMC Public Health. 2017;17(Suppl 5):869.

20. Huynh H, Wan Y (2018) mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1. CommunBiol 1:29

21. ParticipACTION. The Role of the Family in the Physical Activity, Sedentary and Sleep Behaviours of Children and Youth. The 2020 ParticipACTION Report Card on Physical Activity for Children and Youth. Toronto: ParticipACTION; 2020.

22. C. Song, J. Cao, Y. Lei, H. Chi, P. Kong, G. Chen, T. Yu, J. Li, R. Kumar Prajapati, J. Xia, J. Yan Nuciferine prevents bone loss by disrupting multinucleated osteoclast formation and promoting type H vessel formation FASEB J. (2020)

23. Andreotti G, Méndez BL, Amodeo P, Morelli MAC, Nakamuta H, Motta A. Structural Determinants of Salmon Calcitonin Bioactivity-The Role of the Leu Based Amphiphatic α-helix. J Biol Chem 2006; 281:24193- 24203.

24. Green FR, Lynch B, Kaiser ET. Biological and physical properties of a model calcitonin containing a glutamate residue interrupting the hydrophobic face of the idealized amphiphilic alphahelical region. Proc Natl Acad Sci USA 1987;84:8340-8344.