USE OF AMELOGENIN IN TREATMENT OF CARIES
Abstract
Tooth enamel is the hardest tissue in the human body. Mature enamel is an inanimate tissue and can not regenerate after a significant loss of minerals, which often arises from caries or erosion. Despite efforts to remineralize enamel, the prevention and treatment of initial carious lesions and submicrometric erosion are still major clinical problems. Currently, these lesions are treated by removing the altered tissue and filling the resulting cavity with restorative materials. As a potential alternative to traditional treatment, the biomimetic reconstruction of tooth enamel can regenerate the organized enamel-imitating apatite crystals with reliable binding to the surface of natural enamel. In recent studies, the Kazakhstan researcher BA Aituov developed a drug for non-invasive treatment of focal demineralization of tooth enamel, a biocompatible synthetic analog of the human amelogenin protein, which plays a key role in the formation of enamel in odontogenesis. However, this technique has no experimental studies on animals and has insufficient clinical data and morphological justification for the processes of enamel regeneration. Therefore, the solution of this urgent problem will allow us to study in more detail the processes occurring in the enamel of the teeth upon exposure to this preparation.
References
1. Altarabulsi M. B. Clinical safety, quality and effect of resin infiltration for proximal caries / M. B. Altarabulsi, M. Alkilzy, M. A. Petrou //Eur. J. paediatr. dent. - 2014. - V. 15 (1). - P. 39-44.
2. Arends J. The nature of early caries lesions in enamel /J. Arends, J. Christoffersen //J. Dent. Res. - 1986. - № 65. - P. 2-11.
3. Arnaud T. M. Chitosan effect on dental enamel deremineralization: An in vitro evaluation /T. M. Arnaud, B. D. Neto, F. B. Diniz //J. Dent. - 2010. - № 8. - P. 848-852.
4. Bonde J. S. Use of human amelogenin in molecular encapsulation for the design of pH responsive microparticles /J. S. Bonde, L. Bulow // BMC Biotechnol. - 2012. - №12. - P. 34-39.
5. Buzalaf M. A. PH-cycling models for in vitro evaluation of the efficacy of fluoridated dentifrices for caries control: strengths and limitations /M. A. Buzalaf, A. R. Hannas, A. C. Magalhaes //J. Appl. Oral. Sci. - 2010. - №18. -P. 316-334.
6. Cummins. Working Group Report 3: Role of models in assessing new agents for caries prevention /Adv. Dent. Res. - 1995. - №9. - P. 338339.
7. De Almeida Pdel V. Saliva composition and functions: a comprehensive review /V. de Almeida Pdel, A. M. Gregio, M. A. Machado //J. Contemp. Dent. Pract. - 2008. - №9. - P. 72-80.
8. De Marsillac Mde W. Assesment of artificial caries lesions through scanning electron microscopy and cross-sectional microhardness test / W. de Marsillac Mde, S. Vieira Rde //Indian J. Dent. Res. - 2013. - №24. - P. 249-254.
9. Eccles J. D. Dental erosion of nonindustrial origin. A clinical survey and classification //J. Prosthet Dent. - 1979. - №42. - P. 649-653.
10. Featherstone J. D. The role of remineralizing and anticaries agents in caries management /J. D. Featherstone, S. Domejean //Adv. dent. res. - 2012. - V. 24 (2). - P. 28-31.
11. Ferreira J. M. Therapeutic effect of two fluoride varnishes 13. //Braz. oral. on proximal caries infiltration: three-year follow-up. - 2009. -V. 23 (4). - P. 446-451.
12. Hannig M. Nanomaterials in preventive dentistry /M. Hannig, C. Hannig //Nat. Nanotechnol. - 2010. - №5. - P. 565-569.
13. Humphrey S. P. A review of saliva: Normal composition, flow, and function /S. P. Humphrey, R. T. Williamson //J. Prosthet. Dent. -2001. - №85. - P. 162-169.
14. Jain P. Dental caries and social deprivation /P. Jain, A.Shankar, S. Ramaiah //Lancet. -2007. - №369. - Р. 639.
15. Kumar M. N. A review of chitin and chitosan applications //React. Funct. Polym. - 2000. - №46. - P. 1-27.
16. Lee H. S. Chitosan adsorption on hydroxyapatite and its role in preventing acid erosion /H. S. Lee, S. Tsai, C. C. Kuo //J. Colloid. Interf. Sci. - 2012. - №385. - P. 235-243.
17. Li J. L. Long-term remineralizing effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on early caries lesions in vivo: A systematic review /J. L. Li, X. Xiaoqiu, Yu. Wang //J. Dent. - 2014. - №42. - P. 769-777.
18. Liu W. G. An investigation on the physicochemical properties of chitosan /W. G. Liu, S. J. Sun, Z. Q. Cao et al. //DNA polyelectrolyte complexes. Biomaterials. - 2005. - №26. - P. 27052711.
19. Lussi A. The influence of different factors on in vitro enamel erosion /A. Lussi, T. Jaggi, S. Scharer //Caries. Res. - 1993. - №27. - P. 387 -393.
20. Meurman J. H. Salivary Ph and Glucose after Consuming Various Beverages, Including Sugar-Containing Drinks /J. H. Meurman, I. Rytomaa, K. Kari et al. //Caries Research. - 1987. -№21. - P. 353-359.
21. Meyer-Lueckel H. Improved resin infiltration of natural /H. Meyer-Lueckel, S. Paris //J. dent. res. - 2008. - V. 87 (12). - Р. 1112-1116.
22. Moradian-Oldak J. Protein-mediated enamel mineralization //Front Biosci-Landmark. - 2012. - №17. - P. 1996-2023.
23. Paris S. Infiltration of natural caries lesions with experimental resins differing in penetration coefficients and ethanol addition /S. Paris, H. Meyer-Luckel //Journ. of dental research. -2010. - V. 44 (4). - P. 408-414.
24. Paris S. Resin infiltration of natural caries lesions /S. Paris, H. Meyer-Luckel, A. Kielbassa //Journ. of dental research. - 2007. - V. 86 (7). - P. 662-666.
25. Paris S. Improved resin infiltration of natural caries lesions /S. Paris, H. Meyer-Luckel // Journ. of dental research. - 2008. - V. 87 (12). -P. 1112-1116.
26. Paris S. Penetration coefficients of commercially available and experimental composites intended to infiltrate enamel carious lesions /S. Paris, H. Meyer-Luckel, A. Kielbassa //Dent. mater. - 2007. - V. 23 (6). - P. 742-748.
27. Paris S. Surface layer erosion of natural caries lesions with phosphoric and hydrochloric acid gels in preparation for resin infiltration /S. Paris, H. Meyer-Luckel, A. Kielbassa //Journ. of dental research. - 2007. - V. 41 (3). - P. 223230.
28. Paris S. Micro-hardness and mineral loss of enamel lesions after infiltration with various resins: influence of infiltrant composition and application frequency in vitro /S. Paris, H. Meyer-Luckel, S. Seddig //Journ. of dental research. - 2013. - V. 41 (6). - P. 543-548.
29. Pinto C. F. Effect of 10% carbamide peroxide bleaching on sound and artificial enamel carious lesions /C. F. Pinto, A. F. Paes Leme, V. Cavalli //Braz. Dent. J. - 2009. - №20. - P. 4853.
30. Ruan Q. C. Amelogenin and enamel biomimetics /Q. C. Ruan, J. Moradian-Oldak // Journ. of Materials Chemistry B. - 2015. - №3. -P. 3112-3129.
31. Ruan Q. C. An amelogenin-chitosan matrix promotes assembly of an enamel-like layer with a dense interface /Q. C. Ruan, Yu. Zhang, X. Yang et al. //Acta Biomater. - 2013. - №9. - P. 7289-7297.
32. Ruan Q. C. Development of Amelogenin-chitosan Hydrogel for In vitro Enamel Regrowth with a Dense Interface /Q. C. Ruan, J. Moradian-Oldak //J. Vis. Exp. - 2014. - V. 16. - P. 89.
33. Ruan Q. C. Amelogenin-chitosan matrix for human enamel regrowth: effects of viscosity and supersaturation degree /Q. C. Ruan, N. Siddiqah, X. C. Li //Connective Tissue Research. - 2014. - №55. - P. 150-154.
34. Selwitz R. H. Dental caries /R. H. Selwitz, A. I. Ismail, N. B. Pitts //Lancet. - 2007. -№369. - P. 51-59.
35. Ten Cate J. M. Alternating demineralization and remineralization of artificial enamel lesions /J. M. ten Cate, P. P. Duijsters //Caries Research. - 1982. - №16. - P. 201-210.
36. Ten Cate J. M. Models and role models //Caries Research. - 2015. - №49. - P. 3-10.
37. Tomihata K. In vitro and in vivo degradation of films of chitin and its deacetylated derivatives /K. Tomihata, Y. Ikada //Biomaterials. -1997. - №18. - P. 567-575.
38. Vashisht R. Remineralization of early enamel lesions using casein phosphopeptide amorphous calcium Phosphate: an ex-vivo study / R. Vashisht, A. Kumar, R. Indira //Contemp. Clin. Dent. - 2010. - №1. - P. 210-213.
39. White D. J. The application of in vitro models to research on demineralization and remineralization of the teeth //Journ. of Applied Oral Science. - 1995. - №9. - P. 175-193.
40. Yang Y. 8DSS-promoted remineralization of initial enamel caries in vitro /Y. Yang, X. P. Liv, W. Shi //J. Dent. Res. - 2014. - № 93. - P. 520-524.
41. Yengopal V. Caries preventive effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP): a meta-analysis /V. Yengopal, S. Mickenautsch //Acta. Odontol. Scand. - 2009. - №67. - P. 321-332.
42. Zero D. T. In situ caries models //Journ. of Applied Oral Science. - 1995. - № 9. - P. 214230.
Review
For citations:
Baigulakov A.T. USE OF AMELOGENIN IN TREATMENT OF CARIES. Medicine and ecology. 2018;(2):23-29. (In Russ.)
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