CLINICAL CASE OF A CHILD WITH KAWASAKI-LIKE SYNDROME ASSOCIATED WITH COVID-19

Today, the prevalence of Covid-19 has reached 62 million people. Currently, there are 130 thousand infected people in Kazakhstan. The numbers change daily, as the number of cases is constantly growing. Coronaviruses are a family of viruses that do not have DNA, but their genome is contained in RNA macromolecules. However, also on the territory of Kazakhstan, children had another complication - Kawasaki syndrome. So, in total, the number of people who showed this syndrome reached 14. The article presents a clinical case from the cardiology department of the city children's hospital of Karaganda, in which a male patient at the age of 10 was diagnosed with mucosal lymphonodular syndrome (Kawasaki) Multisystem inflammatory syndrome (Kawasaki-like syndrome) associated with COVID-19. From the anamnesis, it is known that he was ill for several days, there was an increase in temperature to febrile numbers, abdominal pain, and loose stools. Further, a laboratory diagnostic study and an instrumental study were conducted, as well as a consultation with other specialists. Based on the results of these studies, the conclusion was made Multisystem inflammatory syndrome (Kawasaki-like syndrome) associated with Covid-19. Treatment tactics: receiving complex therapy, pulse therapy with corticosteroids, as well as kiovig - human immunoglobulin, which helps to fill the antibody deficit. Against the background of the introduction of this drug, the patient has a positive dynamics.

COVID-19

1. Абатуров А. Е. Патогенез COVID-19 /А. Е. Абатуров, Е. А. Агафонова, Е. Л. Кривуша // Zdorov'e Rebenka. - 2020. - №3. - С. 12-18.

2. Данные ВОЗ. Мультисистемное воспаление у детей /URL: https://apps.who.int/iris/bitstream/handle/10665/332095/WHO-2019-nCoV-Sci_Brief-Multisystem_Syndrome_Children-2020.1-rus.pdf

3. Детский мультисистемный воспалительный синдром, ассоциированный с новой коронавирусной инфекцией (COVID-19): учебное пособие /Ю. Ю. Новикова, Д. Ю. Овсянников, Д. С. Абрамов и др. /Под ред. Д. Ю. Овсянникова, Е. Е. Петряйкиной. - М.: РУДН, 2020. - 62 с.

4. Клинический протокол /URL: https://diseases.medelement.com/disease/коронавирусная-инфекция-2019-ncov-кп-мз-рк/16390

5. Клиническое руководство для педиатрических пациентов с Мультисистемными заболеваниями. Воспалительный синдром у детей (МИС-С), связанный с SARS-CoV-2 и гиперинфляция при COVID-19 /URL: https://www.rheamotology.org

6. Особенности клинических проявлений и лечения заболевания, вызванного новой коронавирусной инфекцией (COVID-19) у детей. /URL: https://minzdrav.gov.ru/ministry/med_covid19

7. Рекомендации для населения в отношении инфекции, вызванной новым коронавирусом (COVID-19) Казахстане /URL: https://www.who.int/ru

8. Статистика по миру /URL: https://yandex.ru/covid19/stat

9. Статистика по регионам КЗ /corona -virus2020.kz URL: https://www.coronavirus2020.kz/

10. Статистика синдромов Кавасаки в Казахстане /URL: https://tengrinews.kz/kazakhstan_news/izvestno-zabolevshih-sindromom-kavasaki-detyah-kazahstane-411524/

11. Филиппов Е. С. Острые аллергические реакции у детей. клиника, диагностика, неотложная помощь /Е. С. Филиппов, М. В. Дудкина. - М., 2003. - 248 с.

12. Kanegaye J. T. Recognition of a Kawasaki disease shock syndrome /J. T. Kanegaye, M.S. Wilder, D. Molkara //Pediatrics. - 2009. - V. 123(5):e783-789.

13. Riphagen S. Hyperinflammatory shock in children during COVID-19 pandemic /S. Riphagen, X. Gomez, C. Gonzalez-Martinez //Lancet. -2020. - V. 23. - P. 1607-1608.

14. Shirato K. Possible involvement of infection with human coronavirus 229E, but not NL63, in Kawasaki disease /K. Shirato, Y. Imada, M. Kawase //J. Med. Virol. - 2014. - V. 86. - P. 2146-2153.

15. Sokolovsky S. COVID-19 associated Kawasaki-like multisystem inflammatory disease in an adult /S. Sokolovsky, P. Soni, T. Hoffman // American Journal of Emergency Medicine. - 2020. -V. 4. - P. 234-238.