COMPARATIVE ASPECTS OF LAMBLIOSIS TREATMENT SCHEMES

Unmasked randomized controlled clinical trial was conducted on the base of Karaganda medical university. In this study, 250 patients participated, after signed forms of information consent aged 18 to 45 years, with a verified diagnosis of acute or chronic giardiasis . When selecting patients for treatment with the drug «Sausalin» and «Ornisid» we formed two groups. In group 1 (125) patients took the drug Sausalin (main group), at a dose of 240 mg (2 tablets 4 times a day) for 14 days. The second comparison group included (125) patients receiving Ornisid (500 mg), 1 tablet 2 times a day for 10 days. When using these schemes, a high percentage of parasite eradication was obtained according to the results of microscopic studies. The study determined the efficacy of the drug Sausalin, which was more pronounced than the Ornisid preparations used at the present stage of giardiasis treatment.

giardiasis, treatment regimens, antiparasitic drug, effectiveness

1. Адекенов С. Перспективы развития фармацевтической индустрии в Республике Казахстан //Современные медицинские технологии. - 2012. - №8. - C. 79-81.

2. Акобиршоева А. А. Некоторые этнокультурные аспекты использования лекарственных растений Рушанского района (Таджикистан) //Растительные ресурсы. - 2009. - №1. - C. 122-125.

3. Драб А. И. Фармакологические свойства экстракта соссюреи солончаковой: Автореф.. канд. мед. наук. - Караганда, 2005. - 25 с.

4. Исследование противолямблиозной активности фитопрепарата «Саусалин» /Д. Д. Мухамбетов, Д. А. Баешева, А. Б. Жумабекова и др. //Астана медициналык журналы. - 2011. -№6. - C. 38-41.

5. Погодин И. С. Химический состав растений рода SaussureaDC, произрастающих на тераиторрии Сибири / И. С. Погодин, Е. А. Лукша, Н. А. Предейн //Химия растительного сырья. - 2014. - №3.- С. 43-52.

6. Усенко Д. В. Современные аспекты диагностики и лечения лямблиоза.// Вопросы современной педиатрии. - 2015. - Т. 14, №1. -С. 108-113.

7. Al-kaissi I. N. The effect of Aqueous some plants Extract on Giardia lamblia in vitro //Al-Anbar J. Vet. Sci. - 2010. - V. 3, №2. - P. 48-58.

8. Cho J. et al. Inhibitory effect of sesquiterpene lactones from Saussurea lappa on tumor necrosis factor-alpha production in murine macrophage like cells //Planta Medica. - 1998. - V. 64, №7. - P. 594-597.

9. Damre A. A. Evaluation of sesquiterpene lactone fraction of Saussurea lappa on tran-sudative, exudative and proliferative phases of inflammation /A.A. Damre, A. S. Damre, M. N. Saraf // Phytother. Res. - 2003. - V. 17, №7. -P. 722-725.

10. Escobedo A. A. Comparison of chloro-quine, albendazole and tinidazole in the treatment of children with giardiasis /A. A. Escobedo, F. A. Nunez, I. Moreira //Ann. Tropic. Med. & Parasitol. - 2003. - V. 97 (4). - P. 367-371.

11. Granados Carlos E. Drugs for treating giardiasis //Cochrane Database of Systematic Reviews. - 2012. - №12. - P. 1-73.

12. Identification of growth nhibiting compounds in a Giardia lamblia high-throughput screen /R. Bonilla-Santiago, Z. Wu, L. Zhang, G. Widmer //Mol. Biochem. Parasitol. -2008.- V. 162, №2. - P. 149-154.

13. Leticia E. Giardia intestinalis: Expression of ubiquitin, glucosamine-6-phosphate and cyst wall protein genes during the encystment process //Experimental Parasitology. - 2011. -№127. - P. 382-386.

14. Pandey M. M. Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant /M. M. Pandey, S. Rastogi, K. S. Rawat // Journal of Ethnopharma-cology. - 2007. - №110. - P. 379-390.

15. Plant species used in giardiasis treatment: ethnopharmacology and in vitro evaluation of anti-Giardia activity /V. Neiva, M. N. Ribeiro, F. R. Nascimento et al. //Revista Brasileira de Far-macognosia. - 2014. - V. 24, №2. - P. 215-224.

16. Solaymani-Mohammadi S. A. Meta-analysis of the Effectiveness of Albendazole Compared with Metronidazole as Treatments for Infections with Giardia duodenalis //PLOS Neglected Tropical Diseases. - 2010. - V. 4, №5. - Р. 682.

17. Tagboto S. Antiparasitic properties of medicinal plants and other naturally occurring products /S. Tagboto, S. Townson //Advances in Parasitology. - 2001. - №50. - P. 199-295.