TO THE PROBLEM OF MODELING STRESS DISORDERS IN ANIMAL EXPERIMENT

This article discusses the problems of experimental modeling of mental disorders in the aspect of clinical medicine. Modern ideas about psychopathology present new demands for experimental science in order to create valid models of behavioral and emotional disorders. At the present stage of the scientific development the modeling of the psychopathology is significantly difficult or even impossible due to its high specificity. The need for pharmacological studies of the new drugs requires a common etiological, pathogenetic mechanisms of the modeling and reproduction of clinical symptoms in the experiment. Stress-induced modeling has been used in the experimental science for a long time and is becoming increasingly important. The prolonged effect of stress on the human body is known to be considered a leading factor in the development of borderline disorders and adaptation disorders. The personal reaction to stress in the complex of internal and external contradictions is capable of forming various types of the symptom complexes of the neurotic spectrum. Prolonged exposure of the individual to the increasing psycho-emotional stress in the modern society causes an increased frequency of borderline disorders. A variety of syndromes, united into a group of adaptation disorders, are considered a standard of a promising experimental model. Conditions comparable to the mechanism of the adaptation disorders development in humans are reproducible in the «Chronic Unpredictable Moderate Stress» model, which suggests prolonged exposure to a variety of alternating stress factors of moderate intensity. This mechanism of action prevents adaptation, does not have an excessive traumatic effect, and allows to dynamically observe animals in the process of model formation and in the study of the pharmacological profile of psychotropic drugs. The use of a sustainable model of stress-induced disorders will expand the possibilities of studying the biochemical, pathomorphological factors of their development and the possibilities of pharmacotherapeutic effects.

experimental models, stress disorders, chronic unpredictable moderate stress, stress-induced disorders, adaptation disorders

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