NEUTROPHIL EXTRACELLULAR TRAPS: FORMATION MECHANISMS
Abstract
Neutrophil extracellular traps are a new paradigm in immune-mediated immunity. NET is considered to be a highly conserved antimicrobial strategy that includes decondensed nuclear DNA and its associated histones, which are extruded into the extracellular space. A number of antimicrobial peptides, which contribute to the extracellular destruction of microorganisms that enter the network, are associated with DNA strands. It has been established that neutrophilic traps have a dual role: on the one hand, they perform a protective function, on the other hand, they are potential mediators of tissue damage. In this regard, the assessment of the extracellular traps formation is of absolute relevance and importance because it can largely determine the development and outcomes of various pathologies.
About the Authors
M. .. Maratkyzy
NC JSC«Karaganda medical university»
Kazakhstan
Kazakhstan
A. Ye. Kosybayeva
NC JSC«Karaganda medical university»
Kazakhstan
Kazakhstan
References
1. Андрюков Б. Г. Нейтрофильная защитная стратегия против патогенных бактерий /Б. Г. Андрюков, Л. М. Сомова. Л. М. Дробот //Здоровье. Медицинская экология. Наука. - 2017. -№1. - С. 4-18.
2. Коротина О. Л. Нейтрофильные внеклеточные ловушки: механизмы образования, функции /О. Л. Коротина, И. И. Генералов // Иммунология, аллергология, инфектология. - 2012. - №4. - С. 23-32.
3. Коротина О. Л. Нейтрофильные внеклеточные ловушки: механизмы образования, функции /О. Л. Коротина, И. И. Генералов // Иммунология, аллергология, инфектология. - 2012. - №4. - С. 23-32.
4. Косыбаева А. Е. Современное представление о механизмах образования нейтрофильных внеклеточных ловушек /А. Е. Косыбаева, М. М. Мараткызы, Э. В. Итаева //Междунар. студ. науч. вестник. - 2019. - №1. - С. 56-61.
5. Borregaard N. Neutrophils, from marrow to microbes // Immunity. - 2010. - №33. -Рр. 657-670.
6. Branzk N. Molecular mechanisms regulating NETosis in infection and disease /N. Branzk, V. Papayannopoulos //Semin Immunopathol. - 2013. - V. 35(4). - P. 513-530.
7. Brinkmann V/ Neutrophil extracelllulartraps kill bacteria /V. Brinkmann, U. Rechard, C. Goosmann //Science. - 2004. - №303. - Рр. 1532-1535.
8. Brinkmann V. Automatic quantification in vitro NET formation /V. Brinkmann, C. Goosmann, A. Zychlinsky //Frontiers in Immunology. - 2013. - №3. - Рр. 413-418.
9. Brinkmann V. Beneficial suicide: why neutrophils die to, make NETs /V. Brinkmann, A. Zychlinsky //NatureRev. - 2007. - №5. - Рр. 577-582.
10. Brinkmann V. Neutrophil Extracellular Traps in the Second Decade //J. Innate Immun. -2018. - №10. - С. 414-421.
11. Brinkmann V. Neutrophil extracellular traps: how to generate and visualize them /V. Brinkmann, B. Laube, U. Abu Abed //Journ/ of Visualized experiments. - 2010. - V. 14. - Pp. 24-36.
12. Brinkmann V. Automatic quantification of in vitroNET formation /V. Brinkmann, C. Goosmann, L. I. Kuhn //Front. Immunol. - 2013. -V. 3. - P. 413.
13. Brinkmann V. Neutrophil extracellular traps: is immunity the second function of chromatin? /V. Brinkmann, A. Zychlinsky //J. Cell Biol. -2012. - №198. - Рр. 773-783.
14. Dwyer M. Cystic fibrosis sputum DNA has NETosis characteristics and neutrophil extracellular trap release is regulated by macrophage migration-inhibitory factor //J Innate Immun. - 2016. - Т. 6. - №6. - Рр. 765-779.
15. Fuchs H. J. Effect of Aerosolized Recombinant Human Dnase on Exacerbationsof Respiratory Symptoms and on Pulmonary Function in Patients with Cystic Fibrosis /H. J. Fuchs, D. S. Borowitz, D. H. Christiansen //New England Journal of Medicine. - 2014. - №331 (10). - Рр. 637-642.
16. Fuchs T. A. Novel cells death program leads to neutrophil extracelllular traps /T. A. Fuchs, U. Abed, C. J. Goosmann //Cell Biol. - 2017. - №176 (2). - Рр. 231-241.
17. Itagaki K. Mitochondrial DNA released by trauma induces neutrophil extracellular traps / K. Itagaki, E. Kaczmarek, Y. T. Lee //PLoS One. - 2015. - V. 10 (3). - Рр.10-11.
18. Kobayashi S. D. Neutrophils in the innate immune response /S. D. Kobayashi, J. M. Voyich, C. Burlak //Archivum Immunologiae et Therapiae Experimental. - 2005. - V. 4. - Pp. 17-53.
19. Lood C. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease // Nat. Med. - 2016. - №22. - Рр. 146-153.
20. Mayadas T. N. The Multifaceted Functions of Neutrophils /T. N. Mayadas, X. Cullere, C. A. Lowell //Annu. Rev. Pathol. - 2014. - №9. -С. 181-218.
21. Pijanowski L. Carp neutrophilic granulocytes form extracellular traps via ROS-dependent and independent pathways /L. Golbach, E. Kolaczkowska, M. Scheer //Shellfish Immunol. - 2013. - V. 34(5). - Рр. 1244-1252.
22. Pilsczek F. H. A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus /F. H. Pilsczek, D. Salina, K. K. Poon //J. Immunol. -2012. №185. - Рр. 7413-7425.
23. Scapini P. The neutrophil as a cellular source of chemokines. Immunological /P. Scapini, J. A. Lapinet-Vera, S. Gasperini //Reviews. -2010. - №177. - Рр. 19-203.
24. Venizelos Papayannopoulos. Neutrophil extracellular traps in immunity and disease //Nature Reviews Immunology. - 2018. -№18. - Рр. 134-147.
25. Woodfin A. Recent developments and complexities in neutrophil transmigration /A. Woodfin, M. B. Voisin, S. Nourshargh //Curr. Opin. Hematol. - 2010. - №17. - Рр. 9-17
26. Yipp B. G. NETosis: how vital is it? /B. G. Yipp, P. Kubes //Blood. - 2013. - Т 22. -№16. - Рр. 2784-2794.
27. Yousefi S. Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps. /S. Yousefi, C. Mihalache, E. Kozlowski //Cell Death Differ. - 2009. - V. 16. - P. 1438-1444.
Review
For citations:
Maratkyzy M..., Kosybayeva A.Ye. NEUTROPHIL EXTRACELLULAR TRAPS: FORMATION MECHANISMS. Medicine and ecology. 2019;(4):19-23. (In Russ.)
Views: 211
Email this article 