Comparative analysis of methods of isolation of P-vitamin flavonoids from vegetable raw materials of Japanese sophora
https://doi.org/10.59598/ME-2305-6053-2026-120-3-152-157
Abstract
The article describes the possibility of obtaining P-vitamin flavonoids from Japanese sophora (Styphnolobium japonicum) flowers by extraction with acidified water at high temperature. In this system, water acts both as a reagent and as a solvent. The proposed approach eliminates the use of toxic organic compounds, combines the extraction and hydrolysis stages, and facilitates the final stage of purification. It has been established that the proposed method is more environmentally friendly than the known ones and allows several times to reduce the production time compared to the known traditional methods.
The innovative method of obtaining the antioxidant quercetin is based on high-temperature treatment of Japanese sophora flowers in an aqueous medium with the addition of mineral acids. This technological approach eliminates the need for expensive and toxic organic reagents. Combining the extraction and hydrolysis steps into one process optimizes the work cycle and simplifies the subsequent purification of the target products.
About the Authors
R. M. AnarbayevaKazakhstan
160019, Shymkent c., Al-Farabi Square, 1/1
N. U. Kamalova
Kazakhstan
160019, Shymkent c., Tauke Khan ave., 5
R. S. Tashmenov
Kazakhstan
160019, Shymkent c., Tauke Khan ave., 5
Zh. S. Тоxanbayeva
Kazakhstan
Zhanat Sadebekovna Toxanbayeva
160019, Shymkent c., Al-Farabi Square, 1/1
Zh. B. Kaldybekova
Kazakhstan
160019, Shymkent c., Tauke Khan ave., 5
Zh. A. Baimuratova
Kazakhstan
160019, Shymkent c., Tauke Khan ave., 5
References
1. Biasutto L., Marotta E., De Marchi U., Zoratti M., Paradisi C. Ester-based precursors to increase the bioavailability of quercetin. J. Med. Chem. 2007; 50: 241-253. https://doi.org/10.1021/jm060912x
2. D’Archivio M., Filesi C., Varì R., Scazzocchio B., Masella R. Bioavailability of the polyphenols: status and controversies. Int. J. Mol. Sci. 2010; 11 (4): 1321-42. https://doi.org/10.3390/ijms11041321
3. Walle U.K., Walle T. Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. Drug. Metab. Dispos. 2007; 35 (11): 1985-1989. https://doi.org/10.1124/dmd.107.016782
4. Jovanovic S.V., Steeden S., Tosic M., Marjanovic B., Simic G.M. Flavonoids as antioxidants. J. Am. Chem. Soc. 1994; 116: 4846-4851.
5. Mattarei A., Biasutto L., Rastrelli F., Garbisa S., Marotta E., Zoratti M., Paradisi C. Regioselective O-derivatization of quercetin via ester intermediates. An improved synthesis of rhamnetin and development of a new mitochondriotropic derivative. Molecules. 2010; 15 (7): 4722-36. https://doi.org/10.3390/molecules15074722
6. Wei B.L., Lu C.M., Tsao L.T., Wang J.P., Lin C.N. In vitro anti-inflammatory effects of quercetin 3-O-methyl ether and other constituents from Rhamnus species. Planta Med. 2001; 67 (8): 745-747. https://doi.org/10.1055/s-2001-18339
7. Korul’kin D.Ju., Abilov Zh.A., Muzychkina R.A., Tolstikov G.A. Prirodnye flavonoidy. Novosibirsk: Teo; 2007: 232.
8. Middleton E. Jr, Kandaswami C., Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 2000; 52 (4): 673-751.
9. Тashmenov R.S., Toxanbayeva Z.S., Janpaizova V.M. et al. Extraction of Phytin from RiceGrain Processing Byproducts. Pharm. Chem. J. 2020; 54: 61-63. https://doi.org/10.1007/s11094-020-02156-4
Review
For citations:
Anarbayeva R.M., Kamalova N.U., Tashmenov R.S., Тоxanbayeva Zh.S., Kaldybekova Zh.B., Baimuratova Zh.A. Comparative analysis of methods of isolation of P-vitamin flavonoids from vegetable raw materials of Japanese sophora. Medicine and ecology. 2026;(3):152-157. (In Kazakh) https://doi.org/10.59598/ME-2305-6053-2026-120-3-152-157
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