Morphogenesis and morphological verification of Wilms tumor

Nephroblastoma is the most common high-grade embryonic tumor of the genitourinary tract in children. Considering the violation of the processes of nephrogenesis, it should be assumed that congenital renal dysembriogenesis is important among the pathogenetic mechanisms of nephroblastoma formation. The trigger of the tumor process can be elements of foci of dysplastic structures in the form of primitive tubular structures and metanephrogenic tissue in children at risk born to mothers with a complicated pregnancy and the presence of somatic kidney pathology.

The article presents a case of morphological verification of a clinical diagnosis in an 8-year-old patient. This clinical case demonstrates that when making a clinical diagnosis, it is necessary to carefully collect the medical history of the disease, find out the gestation period and features of the course of pregnancy, the presence of risk factors that could affect the features of the intrauterine development of the fetus and newborn, and the histogenesis of the kidneys. Taking into account the comprehensive approach to the differential diagnosis of the pathological process, it is necessary to evaluate the results of modern methods of radiation diagnostics and additional research methods.

The described clinical case proves once again that a multidisciplinary, integrated approach should be applied when making a clinical diagnosis. In the morphological verification of the clinical diagnosis, it is of great diagnostic importance to conduct an immunohistochemical study to determine the phenotype and proliferative activity of the tumor.

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