Role of the enzyme diamine oxidase in the development of urticaria in children

The review provides an analysis of the role of the activity of the enzyme diamine oxidase in the diagnosis of urticaria in children. The authors conducted a traditional search for sources in the databases PubMed, Web of Science, ScienceDirect, Google Scholar in Kazakh, Russian and English, which are in open full-text access and contain statistically confirmed conclusions, the search depth was from 1990 to 2024. The initial literature search revealed 413 articles from the PubMed database, Google Scholar 104 articles, Web of Science 10 articles, ScienceDirect 312 articles. Seventy one sources were selected as analytical materials. Summary reports, newspaper articles, and personal messages were excluded from the review.

In recent years, there has been an increase in allergic diseases among children, urticaria is caused by food allergens, is the most common. Histamine is one of the important mediators of urticaria and belongs to biogenic amines. Eating foods rich in histamine can cause symptoms of allergic reactions. The main enzyme of histamine metabolism is diamine oxidase, which is mainly present in intestinal epithelial cells. Measurement of serum diamine oxidase is used as the main diagnostic test and the usefulness of measuring serum diamine oxidase activity in the diagnosis of histamine intolerance has been confirmed in scientific studies, although conflicting results have been reported in scientific literature on the usefulness of measuring diamine oxidase in the diagnosis of histamine intolerance.

The enzyme diamine oxidase provides new opportunities in the diagnosis of urticaria. In this regard, this problem requires more careful study in relation to children, since it is very difficult for them to recognize this disease and prevent its further development.

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