PREOPERATIVE USE OF PLATELET-RICH PLASMA IN COMBINATION WITH STROMAL VASCULAR FRACTION IN TREATMENT OF LONG NON-HEALING WOUNDS

Aim. Comparative morphometric, histological, and histochemical evaluation of the efficacy of combined application of stromal vascular fraction (SVF) and platelet-rich plasma (PRP) in the treatment of long non-healing wounds in an experi- mental model.

Materials and methods. A randomized experimental study was conducted on 32 rabbits. Excisional wounds with a diameter of 2 cm were created on the animals' backs. The animals were randomly divided into four groups: control group (standard treatment), group with preoperative treatment using physiological saline, group with preoperative PRP+SVF injection, and group with both preoperative and postoperative PRP+SVF injections. The effectiveness was assessed using morphometric, histological, and histochemical methods.

Results. The combined use of PRP and SVF enhanced angiogenesis, stimulated collagen synthesis, and reduced inflammatory cell infiltration.

Conclusion. The combined use of PRP and SVF significantly improves tissue regeneration quality and may be an effective method for the treatment of chronic wounds.

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