PECUUARITJES OF MEDICINAL SEDATION IN PATIENTS OF THE DEPARTMENT OF REANIMATION AND INTENSIVE THERAPY

Objective: to study the characteristics and effectiveness of drug sedation in patients of the intensive care unit. Materials and methods: the study used clinical and laboratory data from 100 patients who are being treated in the intensive care unit. Patient data were divided into 3 groups, depending on the type of drug sedation used. Assessment of the depth of drug sedation was carried out on the Richmond Agitation-Sedation Scale (RASS) scale. Assessment of side effects of the drugs was carried out according to clinical and laboratory data. The changes in the cardiovascular system, the dynamics of ALT, AST, total bilirubin and creatinine levels were taken into account. Results and discussion: according to a behavioral study, 99 (99%) patients managed to achieve the desired result. Regardless of the drug used, in all three groups, sedation levels were on average equal. When assessing the frequency and nature of side effects from the cardiovascular system, 11 patients (11%) developed clinically significant arterial hypotension. When assessing the dynamics of laboratory parameters, no significant changes were observed. Conclusions: based on the results of the study, it was found that the use of dexmedetomidine, propofol, sodium thiopental preparations for drug sedation in patients is an important component of intensive care. Dexmedetomidine may be considered the most effective drug. Arterial hypotension can be distinguished of the clinically significant side effects of the action of sedatives.

sedation, intensive care unit, anxiety, sedative drugs, side effect

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