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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medecol</journal-id><journal-title-group><journal-title xml:lang="ru">Медицина и экология</journal-title><trans-title-group xml:lang="en"><trans-title>Medicine and ecology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-6045</issn><issn pub-type="epub">2305-6053</issn><publisher><publisher-name>Карагандинский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.59598/ME-2305-6053-2025-115-2-80-85</article-id><article-id custom-type="elpub" pub-id-type="custom">medecol-996</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭКОЛОГИЯ И ГИГИЕНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ECOLOGY AND HYGIENE</subject></subj-group></article-categories><title-group><article-title>Анализ факторов, влияющих на вероятность формирования врожденного порока развития плода</article-title><trans-title-group xml:lang="en"><trans-title>STUDY OF THE FACTORS INFLUENCING THE PROBABILITY OF THE FORMATION OF A CONGENITAL MALFORMATION OF THE FETUS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулбаева</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulbaeva</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>160019, ЮКО, г. Шымкент, площадь Аль-Фараби 1</p></bio><bio xml:lang="en"><p>160019, South Kazakhstan region, Shymkent, Al-Farabi Square 1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жумадилова</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhumadilova</surname><given-names>A. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>160019, ЮКО, г. Шымкент, площадь Аль-Фараби 1</p></bio><bio xml:lang="en"><p>160019, South Kazakhstan region, Shymkent, Al-Farabi Square 1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Акбердиева</surname><given-names>Г. У.</given-names></name><name name-style="western" xml:lang="en"><surname>Akberdiyeva</surname><given-names>G. U.</given-names></name></name-alternatives><bio xml:lang="ru"><p>160019, ЮКО, г. Шымкент, площадь Аль-Фараби 1</p></bio><bio xml:lang="en"><p>160019, South Kazakhstan region, Shymkent, Al-Farabi Square 1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сагиндикова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sagindikova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>160019, г. Шымкент, ул. Байтерекова 51/1</p></bio><bio xml:lang="en"><p>160019, Shymkent, Baiterekova str., 51/1</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Саркулова</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sarkulovа</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>160019, г. Шымкент, А. Байтурсынова 7/7</p></bio><bio xml:lang="en"><p>160019, Shymkent, A. Baitursynova str., 7/7</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коптаева</surname><given-names>А. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Koptaeva</surname><given-names>A. K.</given-names></name></name-alternatives><bio xml:lang="en"><p>160019, South Kazakhstan region, Shymkent, Al-Farabi Square 1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">АО «Южно-Казахстанская медицинская академия»<country>Казахстан</country></aff><aff xml:lang="en">South Kazakhstan Medical Academy JSC<country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Маммологический центр «DiVera»<country>Казахстан</country></aff><aff xml:lang="en">DiVera Breast center<country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Международный казахско-турецкий университет им. Ходжи Ахмеда Ясави<country>Казахстан</country></aff><aff xml:lang="en">International Kazakh-Turkish University named after Khoja Ahmed Yasawi<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>09</day><month>08</month><year>2025</year></pub-date><volume>0</volume><issue>2</issue><fpage>80</fpage><lpage>85</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кулбаева С.Н., Жумадилова А.Р., Акбердиева Г.У., Сагиндикова А.А., Саркулова И.С., Коптаева А.К., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Кулбаева С.Н., Жумадилова А.Р., Акбердиева Г.У., Сагиндикова А.А., Саркулова И.С., Коптаева А.К.</copyright-holder><copyright-holder xml:lang="en">Kulbaeva S.N., Zhumadilova A.R., Akberdiyeva G.U., Sagindikova A.A., Sarkulovа I.S., Koptaeva A.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medecol.qmu.kz/jour/article/view/996">https://medecol.qmu.kz/jour/article/view/996</self-uri><abstract><sec><title>Введение</title><p>Введение. Врожденные пороки развития плода являются одной из актуальных проблем здравоохранения в связи с распространением многочисленных факторов риска, увеличением стрессовых ситуаций, бесконтрольным приемом лекарственных препаратов беременными женщинами, а также широким распространением вредных привычек и инфекционных заболеваний среди населения.</p></sec><sec><title>Цель</title><p>Цель. Изучение факторов, влияющих на возникновение врожденных пороков развития плода.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В ходе исследования нами были проанализированы данные 697 женщин, прошедших амбулаторное ультразвуковое исследование во время беременности. Проанализировали данные 697 женщин, которых в зависимости от наличия признаков врожденных пороков развития плода разделили на две группы. В основную группу вошли 466 женщин, у которых во время беременности или в ранний постнатальный период были выявлены врожденные пороки развития новорожденного. В контрольную группу вошли 231 женщина, у детей которых признаки врожденных пороков развития не проявились ни во время беременности, ни в ранний неонатальный период.</p></sec><sec><title>Результаты</title><p>Результаты. Самый ранний срок выявления врожденных пороков развития плода составил 24,7±0,9 нед. беременности, что наблюдалось при наличии сочетанных пороков и пороков центральной нервной системы. Минимальный срок выявления этих врожденных пороков развития для всей исследуемой группы составил 11,5 нед. Далее по частоте выявления следовали врожденные пороки мочевыделительной системы – 26,3±1,7 нед., пороки пищеварительной системы – 27,1±2,0 нед., аномалии сердца и крупных сосудов – 27,7±1,0 нед. беременности. Пороки костно-мышечной системы выявлялись на сроке 28,1±1,9 нед., а признаки хромосомных аномалий обнаруживались позже всех – на сроке 29,4±3,2 нед. беременности.</p></sec><sec><title>Выводы</title><p>Выводы. При дальнейшем ведении беременности гестационный возраст, на котором были выявлены тяжелые врожденные пороки развития, имеет решающее значение.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Congenital fetal developmental anomalies are one of the pressing issues in healthcare due to the prevalence of numerous risk factors, the increase in stressful situations, the uncontrolled intake of medications by pregnant women, as well as the widespread occurrence of bad habits and infectious diseases among the population.</p></sec><sec><title>Aim</title><p>Aim. To study the factors influencing the occurrence of congenital fetal anomalies.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. During the study, we analyzed data from 697 women who underwent outpatient ultrasound examination during pregnancy. We analyzed the data of 697 women, who were divided into two groups based on the presence of signs of congenital fetal developmental anomalies. The main group included 466 women whose newborns exhibited congenital developmental anomalies either during pregnancy or in the early postnatal period, while the control group consisted of 231 women whose children showed no signs of congenital developmental anomalies either during pregnancy or in the early neonatal period.</p></sec><sec><title>Results</title><p>Results. According to the obtained results, the earliest detection period for congenital fetal anomalies was 24.7±0.9 weeks of pregnancy, which was observed in cases of combined anomalies and central nervous system defects. The earliest detection period for these congenital anomalies was 11.5 weeks, which was the minimum for the entire studied group. Next in order of detection were congenital anomalies of the urinary system at 26.3±1.7 weeks, digestive system anomalies at 27.1±2.0 weeks, and heart and major blood vessel anomalies at 27.7±1.0 weeks of pregnancy. Musculoskeletal system anomalies were detected at 28.1±1.9 weeks, while chromosomal anomaly signs were identified the latest at 29.4±3.2 weeks of pregnancy.</p></sec><sec><title>Conclusion</title><p>Conclusion. Thus, the gestational age at which severe developmental anomalies are detected plays a crucial role in further pregnancy management.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>фактор</kwd><kwd>пороки развития</kwd><kwd>младенческая смертность</kwd><kwd>ультразвуковое исследование</kwd><kwd>беременность</kwd><kwd>прием</kwd><kwd>плод</kwd><kwd>здоровье</kwd></kwd-group><kwd-group xml:lang="en"><kwd>factor</kwd><kwd>developmental anomalies</kwd><kwd>infant mortality</kwd><kwd>ultrasound examination</kwd><kwd>pregnancy</kwd><kwd>intake</kwd><kwd>fetus</kwd><kwd>health</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Джаманкулова Ф.С., Мусуралиев М.С., Сорокин А.А. 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