medecolМедицина и экологияMedicine and ecology2305-60452305-6053Карагандинский медицинский университет10.59598/ME-2305-6053-2025-115-2-42-59medecol-992Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSПерспективы использования обогащенной тромбоцитами плазмы и производных жировой ткани в хирургической регенеративной медицинеADVANCES IN THE USE OF PLATELET-RICH PLASMA AND ADIPOSE TISSUE DERIVATIVES IN SURGICAL REGENERATIVE MEDICINEТакМ. С.TakM. S.

31538, Асан-си, Чхунчхоннам, Сунчунхян, 22

31538, Asan-si, Chungcheongnam-do, Soonchunhyang-ro, 22

Кафедра пластической и реконструктивной хирургии, Больница Сунчонхянского университета, Медицинский колледж Сунчонхянского университета, Университет СунчонхянЮжная КореяDepartment of Plastic and Reconstructive Surgery, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Soonchunhyang UniversityKorea, Republic of202509082025024259Copyright © Так М.С., 20252025Так М.С.Tak M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medecol.qmu.kz/jour/article/view/992Введение

Введение. Производные жировой ткани и плазма, обогащенная тромбоцитами (PRP), представляют собой перспективные средства регенеративной медицины и эстетической хирургии благодаря способности стимулировать восстановление тканей, усиливать ангиогенез и снижать воспаление. Их комбинированное применение активно внедряется в реконструктивной и пластической хирургии.

Цель

Цель. Оценить биологические функции и клинический потенциал производных жировой ткани и PRP в хирургии, особенно в контексте увеличения выживаемости жировых трансплантатов и регенерации тканей.

Проведён систематический обзор литературы с использованием баз данных PubMed, Scopus и Web of Science по протоколу PRISMA. Включались оригинальные исследования, обзоры и клинические испытания, посвящённые биологическим свойствам, механизмам действия и хирургическим результатам применения жировой ткани и PRP.

Жировая ткань содержит мультипотентные мезенхимальные стволовые клетки, способствующие ангиогенезу, иммуномодуляции и ремоделированию внеклеточного матрикса. PRP богат факторами роста, которые поддерживают клеточную пролиферацию, интеграцию трансплантата и контроль воспаления. Совместное использование PRP и жира улучшает приживление трансплантата и результаты заживления. Клинико-экспериментальные данные подтверждают улучшенные функциональные и эстетические результаты при реконструкции лица, заживлении ран и операциях на молочной железе.

Заключение

Заключение. Комбинация PRP и жировых производных открывает значительные перспективы в хирургической регенеративной медицине. Однако разнообразие методов подготовки и применения затрудняет сравнение результатов. Необходимы дальнейшие исследования для стандартизации подходов и расширения клинического применения.

Background

Background. Adipose-derived tissues and platelet-rich plasma (PRP) have emerged as promising agents in regenerative medicine and aesthetic surgery due to their ability to stimulate tissue repair, enhance angiogenesis, and reduce inflammation. Their combined use has gained increasing attention in reconstructive and plastic surgical practices.

Aim

Aim. This review aims to evaluate the biological functions and clinical potential of adipose tissue derivatives and PRP in surgical applications, particularly in enhancing fat graft survival and promoting tissue regeneration.

A systematic review of scientific literature was performed using databases such as PubMed, Scopus, and Web of Science, following PRISMA guidelines. The selection criteria included original studies, reviews, and clinical trials focused on the biological properties, therapeutic mechanisms, and surgical outcomes associated with the use of adipose tissue and PRP. Adipose tissue contains multipotent mesenchymal stem cells that contribute to neovascularization, immune modulation, and extracellular matrix remodeling. PRP is rich in growth factors that support cellular proliferation, tissue integration, and inflammation control. The co-administration of PRP with fat grafts improves graft retention and healing outcomes. Several clinical studies demonstrate enhanced aesthetic and functional results in procedures involving facial reconstruction, wound healing, and breast surgery.

Conclusion

Conclusion. The integration of PRP and adipose-derived therapies offers significant advantages in surgical regenerative strategies. However, heterogeneity in preparation methods and application protocols limits comparability across studies. Further research is necessary to standardize techniques, validate outcomes, and broaden the clinical applicability of these regenerative modalities.

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The authors declare that there are no conflicts of interest present.