medecolМедицина и экологияMedicine and ecology2305-60452305-6053Карагандинский медицинский университет10.59598/ME-2305-6053-2025-115-2-29-41medecol-989Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSГеропротективный потенциал растительных и синтетических антиоксидантовGEROPROTECTIVE POTENTIAL OF PLANT AND SYNTHETIC ANTIOXIDANTSШульгауЗ.ShulgauZ.

010000, г. Астана, пр. Кабанбай батыра, 53

010018, г. Астана, ул. А. Бокейхана, 1

010000, г. Астана; пр-т Достык, 13/3, Филиал оздоровительного центра «Бурабай», 5 этаж

010000, Astana city, Kabanbay batyr Ave., 53

010018, Republic of Kazakhstan, Astana city; A. Bokeikhan st., 1

010000, Astana city; Dostyk Ave. 13/3, 5th floor Branch of health and wellness center «Burabay»

НургожинаА.NurgozhinaA.

010000, г. Астана, пр. Кабанбай батыра, 53

010000, г. Астана; пр-т Достык, 13/3, Филиал оздоровительного центра «Бурабай», 5 этаж

010000, Astana city, Kabanbay batyr Ave., 53

010000, Astana city; Dostyk Ave. 13/3, 5th floor Branch of health and wellness center «Burabay»

СадвокасоваД.SadvokassovaD.

010000, г. Астана, пр. Кабанбай батыра, 53

010000, Astana city, Kabanbay batyr Ave., 53

СергазыШ.SergazySh.

010000, г. Астана, пр. Кабанбай батыра, 53

010018, г. Астана, ул. А. Бокейхана, 1

010000, г. Астана; пр-т Достык, 13/3, Филиал оздоровительного центра «Бурабай», 5 этаж

010000, Astana city, Kabanbay batyr Ave., 53

010018, Republic of Kazakhstan, Astana city; A. Bokeikhan st., 1

010000, Astana city; Dostyk Ave. 13/3, 5th floor Branch of health and wellness center «Burabay»

ГуляевА.GulyayevA.

010000, г. Астана, пр. Кабанбай батыра, 53

010018, г. Астана, ул. А. Бокейхана, 1

010000, г. Астана; пр-т Достык, 13/3, Филиал оздоровительного центра «Бурабай», 5 этаж

010000, Astana city, Kabanbay batyr Ave., 53

010018, Republic of Kazakhstan, Astana city; A. Bokeikhan st., 1

010000, Astana city; Dostyk Ave. 13/3, 5th floor Branch of health and wellness center «Burabay»

Национальная лаборатория Астана; Фонд Нурсултана Назарбаева, Институт инновационной и профилактической медицины; Научно-исследовательский институт курортологии и медицинской реабилитации Министерства здравоохранения Республики КазахстанКазахстанNational Laboratory Astana; Nursultan Nazarbayev Foundation, Institute of Innovative and Preventive Medicine; Research Institute of Balneology and Medical Rehabilitation of the Ministry of Health of the Republic of KazakhstanKazakhstanНациональная лаборатория Астана; Научно-исследовательский институт курортологии и медицинской реабилитации Министерства здравоохранения Республики КазахстанКазахстанNational Laboratory Astana; Research Institute of Balneology and Medical Rehabilitation of the Ministry of Health of the Republic of KazakhstanKazakhstanНациональная лаборатория АстанаКазахстанNational Laboratory AstanaKazakhstan202509082025022941Copyright © Шульгау З., Нургожина А., Садвокасова Д., Сергазы Ш., Гуляев А., 20252025Шульгау З., Нургожина А., Садвокасова Д., Сергазы Ш., Гуляев А.Shulgau Z., Nurgozhina A., Sadvokassova D., Sergazy S., Gulyayev A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medecol.qmu.kz/jour/article/view/989

Старение – неизбежный этап жизни, естественный процесс, который мы все переживаем и часто стремимся замедлить. Поскольку продолжительность жизни на Земле продолжает расти, стремление к долголетию и жизненной силе становится все более значимым. Однако наряду с этим увеличением продолжительности жизни мы сталкиваемся с возникновением заболеваний, связанных со старением, и генетических мутаций, которые могут привести к различным осложнениям со здоровьем. Эта двойная проблема давно беспокоит исследователей и специалистов в области здравоохранения.Чтобы смягчить негативное влияние старения на здоровье, крайне важно изучить способы замедления этого процесса. В этой статье рассматриваются несколько перспективных вариантов, которые предполагают их эффективность против старения, потенциально выступая в качестве геропротекторов. Среди них антиоксиданты, пожалуй, являются самым популярным выбором из-за их способности снижать окислительный стресс, вызванный свободными радикалами — нестабильными молекулами, которые могут повреждать клетки и способствовать старению.В дополнение к традиционным антиоксидантам, синтетические антиоксиданты, такие как миметики ферментов, становятся центром терапевтических исследований. Эти соединения направлены на воспроизведение действия природных ферментов, которые борются с окислительным стрессом, предлагая новый подход к проблемам со здоровьем, связанным с возрастом. Кроме того, полифенолы, природные соединения, содержащиеся в различных фруктах, овощах и напитках, таких как чай и красное вино, привлекли внимание из-за их потенциальной пользы для здоровья.Вместе эти соединения могут способствовать новым возможностям исследований, направленных на борьбу с возрастной патологией и улучшение общих показателей здоровья. Понимая и используя силу антиоксидантов, миметиков ферментов и полифенолов, мы можем проложить путь для инновационных вмешательств, которые не только продлят продолжительность жизни, но и улучшат качество жизни людей по мере их старения. Поиск эффективных геропротекторов представляет собой важный рубеж в содействии здоровому старению и профилактике возрастных заболеваний. 

Aging is an inevitable stage of life, a natural process that we all experience and often strive to slow down. As life expectancy on Earth continues to rise, the quest for longevity and vitality becomes increasingly significant. However, alongside this increase in lifespan, we face the emergence of diseases associated with aging and genetic mutations that can lead to various health complications. This dual challenge has long been a concern for researchers and healthcare professionals.

To mitigate the negative impact of aging on health, it is crucial to explore ways to slow down this process. This article discusses several promising options that suggest their effectiveness against aging, potentially acting as geroprotectors. Among these, antioxidants are perhaps the most popular choice due to their ability to reduce oxidative stress caused by free radicals—unstable molecules that can damage cells and contribute to aging.

In addition to traditional antioxidants, synthetic antioxidants such as enzyme mimetics are becoming a focal point of therapeutic research. These compounds aim to replicate the action of natural enzymes that combat oxidative stress, offering a novel approach to age-related health issues. Furthermore, polyphenols, naturally occurring compounds found in various fruits, vegetables, and beverages like tea and red wine, have garnered attention for their potential health benefits.

Together, these compounds may contribute to new research opportunities aimed at combating age-related pathology and improving overall health outcomes. By understanding and harnessing the power of antioxidants, enzyme mimetics, and polyphenols, we may pave the way for innovative interventions that not only extend lifespan but also enhance the quality of life for individuals as they age. The pursuit of effective geroprotectors represents a vital frontier in promoting healthy aging and preventing age-related diseases.

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The authors declare that there are no conflicts of interest present.