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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medecol</journal-id><journal-title-group><journal-title xml:lang="ru">Медицина и экология</journal-title><trans-title-group xml:lang="en"><trans-title>Medicine and ecology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-6045</issn><issn pub-type="epub">2305-6053</issn><publisher><publisher-name>Карагандинский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.59598/ME-2305-6053-2025-114-1-39-46</article-id><article-id custom-type="elpub" pub-id-type="custom">medecol-918</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEWS</subject></subj-group></article-categories><title-group><article-title>Диагностика новообразований простаты</article-title><trans-title-group xml:lang="en"><trans-title>Prostate neoplasm diagnosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ческа</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chesca</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Антонелла Ческа – MD, PhD, заведующая отделением визуализации Клиники физиологии легких г. Брашов; заведующая кафедрой клеточной и молекулярной биологии и гистологии медицинского факультета</p><p>г. Брашов, ул. Б-дул Эройлор, 29</p></bio><bio xml:lang="en"><p>Antonella Chesca – MD, PhD Head of Imagistic Department at Clinic Lung Physiology Hospital, Brasov; Head of Cell and Molecular Biology and Histology at Faculty of Medicine</p><p>Brasov city, B-dul Eroilor nr. 29</p></bio><email xlink:type="simple">anto.chesca@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Трансильванский университет Брашова<country>Румыния</country></aff><aff xml:lang="en">Transilvania University of Brasov<country>Romania</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>16</day><month>05</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>39</fpage><lpage>46</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ческа А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Ческа А.</copyright-holder><copyright-holder xml:lang="en">Chesca A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medecol.qmu.kz/jour/article/view/918">https://medecol.qmu.kz/jour/article/view/918</self-uri><abstract><p>Цель настоящего литературного обзора – в последовательном изучении диагностических этапов рака простаты. Рак простаты классифицируется структурно по шкале Глисона. Фосфатазы участвуют в различных клеточных изменениях, включая пролиферацию, дифференциацию и канцерогенез. В определенных жизненных обстоятельствах белки являются регуляторами, влияющими на внутриклеточные сигнальные пути. Изменения в функциональности фосфатаз представляют собой ключевой момент в малигнизации патологического процесса. Исследователи пытаются исследовать и сделать выводы о раке простаты, используя геномный анализ, клинически важные биомаркеры и методы визуализации. Поэтому, наконец, после следующих этапов описания, целью является предоставление заключения по раку предстательной железы и различным ключевым моментам его развития.</p></abstract><trans-abstract xml:lang="en"><p>Our target point within this following steps, is prostate cancer. Prostate cancer is classified structurally, by its Gleason Score. Phosphatases are implicated in different cell alterations, including proliferation, differentiation and carcinogenesis. In specific life circumstances, proteins are regulators with implications in intracellular signaling pathways. Alterations in phosphatases functionality represent a key point in malignancy development. Researchers try to investigate and to conclude on prostate cancer using also genomic analyses, clinically useful biomarkers and imagistic methods. So finally after following description steps, purposed aim is to conclude on prostate cancer and different key points abordation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>простата</kwd><kwd>функциональность</kwd><kwd>ферментативная активность</kwd><kwd>рак</kwd><kwd>диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>prostate</kwd><kwd>functionality</kwd><kwd>enzymatic activity</kwd><kwd>cancer</kwd><kwd>diagnosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chan J.M., Gann P.H., Giovannucci E.L. Role of diet in prostate cancer development and progression. J. Clin. Oncol. 2005; 23 (32): 8152-8160.</mixed-citation><mixed-citation xml:lang="en">Chan J.M., Gann P.H., Giovannucci E.L. Role of diet in prostate cancer development and progression. J. Clin. Oncol. 2005; 23 (32): 8152-8160.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Giovannucci E., Rimm E.B., Colditz G.A., Stampfer M.J., Ascherio A., Chute C.G., Willett W.C. A prospective study of dietary fat and risk of prostate cancer. J. Natl. Cancer. Inst. 1993; 85 (19): 1571-1579. https://doi.org/10.1093/jnci/85.19.1571</mixed-citation><mixed-citation xml:lang="en">Giovannucci E., Rimm E.B., Colditz G.A., Stampfer M.J., Ascherio A., Chute C.G., Willett W.C. A prospective study of dietary fat and risk of prostate cancer. J. Natl. Cancer. Inst. 1993; 85 (19): 1571-1579. https://doi.org/10.1093/jnci/85.19.1571</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Kolonel L.N., Nomura A.M., Cooney R.V. Dietary fat and prostate cancer: current status. J. Natl. Cancer. Inst. 1999; 91 (5): 414-428.</mixed-citation><mixed-citation xml:lang="en">Kolonel L.N., Nomura A.M., Cooney R.V. Dietary fat and prostate cancer: current status. J. Natl. Cancer. Inst. 1999; 91 (5): 414-428.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Platz E.A., Leitzmann M.F., Michaud D.S., Willett W.C., Giovannucci E. Interrelation of energy intake, body size, and physical activity with prostate cancer in a large prospective cohort study. Cancer Res. 2003; 63 (23): 8542-8548.</mixed-citation><mixed-citation xml:lang="en">Platz E.A., Leitzmann M.F., Michaud D.S., Willett W.C., Giovannucci E. Interrelation of energy intake, body size, and physical activity with prostate cancer in a large prospective cohort study. Cancer Res. 2003; 63 (23): 8542-8548.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Willis M.S., Wians F.H. The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances. Clin. Chim. Acta. 2003; 330 (1-2): 57-83.</mixed-citation><mixed-citation xml:lang="en">Willis M.S., Wians F.H. The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances. Clin. Chim. Acta. 2003; 330 (1-2): 57-83.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Quinn M., Babb P. Patterns and trends in prostate cancer incidence, survival, prevalence and mortality. Part I: international comparisons. BJU Int. 2002; 90 (2): 162- 173.</mixed-citation><mixed-citation xml:lang="en">Quinn M., Babb P. Patterns and trends in prostate cancer incidence, survival, prevalence and mortality. Part I: international comparisons. BJU Int. 2002; 90 (2): 162- 173.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Quinn M., Babb P., Jones J., Allen E. Effect of screening on incidence of and mortality from cancer of cervix in England: evaluation based on routinely collected statistics. BMJ. 1999; 318 (7188): 904-908. https://doi.org/10.1136/bmj.318.7188.904</mixed-citation><mixed-citation xml:lang="en">Quinn M., Babb P., Jones J., Allen E. Effect of screening on incidence of and mortality from cancer of cervix in England: evaluation based on routinely collected statistics. BMJ. 1999; 318 (7188): 904-908. https://doi.org/10.1136/bmj.318.7188.904</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Draisma G., Etzioni R., Tsodikov A., Mariotto A., Wever E., Gulati R., Feuer E. Lead time and overdiagnosis in prostate-specific antigen screening: importance of methods and context. J. Natl. Cancer. Inst. 2009; 101 (6): 374-383.</mixed-citation><mixed-citation xml:lang="en">Draisma G., Etzioni R., Tsodikov A., Mariotto A., Wever E., Gulati R., Feuer E. Lead time and overdiagnosis in prostate-specific antigen screening: importance of methods and context. J. Natl. Cancer. Inst. 2009; 101 (6): 374-383.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Etzioni R., Penson D.F., Legler J.M., di Tommaso D., Boer R., Gann P.H., Feuer E.J. Overdiagnosis due to prostate-specific antigen screening: lessons from U.S. prostate cancer incidence trends. J. Natl. Cancer. Inst. 2002; 94 (13): 981-990.</mixed-citation><mixed-citation xml:lang="en">Etzioni R., Penson D.F., Legler J.M., di Tommaso D., Boer R., Gann P.H., Feuer E.J. Overdiagnosis due to prostate-specific antigen screening: lessons from U.S. prostate cancer incidence trends. J. Natl. Cancer. Inst. 2002; 94 (13): 981-990.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Taitt H.E.. Global Trends and Prostate Cancer: A review of incidence, detection, and mortality as influenced by race, ethnicity, and geographic location. Am. J. Mens Health. 2018; 12 (6): 1807-1823.</mixed-citation><mixed-citation xml:lang="en">Taitt H.E.. Global Trends and Prostate Cancer: A review of incidence, detection, and mortality as influenced by race, ethnicity, and geographic location. Am. J. Mens Health. 2018; 12 (6): 1807-1823.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Collin S.M., Martin R.M., Metcalfe C., Gunnell D., Albertsen P.C., Neal D., Hamdy F. Prostate-cancer mortality in the USA and UK in 1975-2004: an ecological study. Lancet Oncol. 2008; 9 (5): 445-452.</mixed-citation><mixed-citation xml:lang="en">Collin S.M., Martin R.M., Metcalfe C., Gunnell D., Albertsen P.C., Neal D., Hamdy F. Prostate-cancer mortality in the USA and UK in 1975-2004: an ecological study. Lancet Oncol. 2008; 9 (5): 445-452.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Etzioni R., Tsodikov A., Mariotto A., Szabo A., Falcon S., Wegelin J., DiTommaso D. Quantifying the role of PSA screening in the US prostate cancer mortality decline. Cancer Causes Control. 2008; 19 (2): 175-181.</mixed-citation><mixed-citation xml:lang="en">Etzioni R., Tsodikov A., Mariotto A., Szabo A., Falcon S., Wegelin J., DiTommaso D. Quantifying the role of PSA screening in the US prostate cancer mortality decline. Cancer Causes Control. 2008; 19 (2): 175-181.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Lim L.S., Sherin K., Committee A.P.P. Screening for prostate cancer in U.S. men ACPM position statement on preventive practice. Am. J. Prev. Med. 2008; 34 (2): 164-170.</mixed-citation><mixed-citation xml:lang="en">Lim L.S., Sherin K., Committee A.P.P. Screening for prostate cancer in U.S. men ACPM position statement on preventive practice. Am. J. Prev. Med. 2008; 34 (2): 164-170.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Jorgensen J.T. Drug-diagnostics co-development in oncology. Front Oncol. 2014; 4: 208.</mixed-citation><mixed-citation xml:lang="en">Jorgensen J.T. Drug-diagnostics co-development in oncology. Front Oncol. 2014; 4: 208.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Olsen D., Jorgensen J.T. Companion diagnostics for targeted cancer drugs - clinical and regulatory aspects. Front Oncol. 2014; 4: 105.</mixed-citation><mixed-citation xml:lang="en">Olsen D., Jorgensen J.T. Companion diagnostics for targeted cancer drugs - clinical and regulatory aspects. Front Oncol. 2014; 4: 105.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma U., Pal D., Prasad R. Alkaline phosphatase: an overview. Indian J. Clin. Biochem. 2014; 29 (3): 269- 278.</mixed-citation><mixed-citation xml:lang="en">Sharma U., Pal D., Prasad R. Alkaline phosphatase: an overview. Indian J. Clin. Biochem. 2014; 29 (3): 269- 278.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Groot M.T., Boeken Kruger C.G., Pelger R.C., Uylde Groot C.A. Costs of prostate cancer, metastatic to the bone, in The Netherlands. Eur. Urol. 2003; 43 (3): 226- 232.</mixed-citation><mixed-citation xml:lang="en">Groot M.T., Boeken Kruger C.G., Pelger R.C., Uylde Groot C.A. Costs of prostate cancer, metastatic to the bone, in The Netherlands. Eur. Urol. 2003; 43 (3): 226- 232.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Truong L.D., Kadmon D., McCune B.K., Flanders K.C., Scardino P.T., Thompson T.C. Association of transforming growth factor-beta 1 with prostate cancer: An immunohistochemical study. Hum. Pathol. 1993; 24: 4-9.</mixed-citation><mixed-citation xml:lang="en">Truong L.D., Kadmon D., McCune B.K., Flanders K.C., Scardino P.T., Thompson T.C. Association of transforming growth factor-beta 1 with prostate cancer: An immunohistochemical study. Hum. Pathol. 1993; 24: 4-9.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Hobisch A., Eder I. E., Putz T., Horninger W., Bartsch G., Klocker H., Culig Z. Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor. Cancer Res. 1998; 58: 4640-4645.</mixed-citation><mixed-citation xml:lang="en">Hobisch A., Eder I. E., Putz T., Horninger W., Bartsch G., Klocker H., Culig Z. Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor. Cancer Res. 1998; 58: 4640-4645.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Bussemakers M.J., van Bokhoven A., Verhaegh G.W., Smit F.P., Karthaus H.F., Schalken J.A., Debruyne F.M., Ru N., Isaacs W.B. DD3: a new prostate-specific gene, highly overexpressed in prostate cancer. Cancer Res. 1999; 59: 5975-5979.</mixed-citation><mixed-citation xml:lang="en">Bussemakers M.J., van Bokhoven A., Verhaegh G.W., Smit F.P., Karthaus H.F., Schalken J.A., Debruyne F.M., Ru N., Isaacs W.B. DD3: a new prostate-specific gene, highly overexpressed in prostate cancer. Cancer Res. 1999; 59: 5975-5979.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta A., Lotan Y., Ashfaq R., Roehrborn C.G., Raj G.V., Aragaki C.C., Montorsi F., Shariat S.F. Predictive value of the differential expression of the urokinase plasminogen activation axis in radical prostatectomy patients. Eur. Urol. 2009; 55: 1124-1133.</mixed-citation><mixed-citation xml:lang="en">Gupta A., Lotan Y., Ashfaq R., Roehrborn C.G., Raj G.V., Aragaki C.C., Montorsi F., Shariat S.F. Predictive value of the differential expression of the urokinase plasminogen activation axis in radical prostatectomy patients. Eur. Urol. 2009; 55: 1124-1133.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Madu C.O., Lu Y. Novel diagnostic biomarkers for prostate cancer. J. Cancer. 2010; 1: 150-177.</mixed-citation><mixed-citation xml:lang="en">Madu C.O., Lu Y. Novel diagnostic biomarkers for prostate cancer. J. Cancer. 2010; 1: 150-177.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Batta A., Panag K.M.D.S., Singh J. Diagnosis of prostate cancer. Role of biomarkers. Int. J. Cur. Biomed. Phar. Res. 2012; 2: 339-345.</mixed-citation><mixed-citation xml:lang="en">Batta A., Panag K.M.D.S., Singh J. Diagnosis of prostate cancer. Role of biomarkers. Int. J. Cur. Biomed. Phar. Res. 2012; 2: 339-345.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Pinto J.T., Suffoletto B.P., Berzin T.M. Prostatespecific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells. Clin Cancer Res. 1996; 2: 1445-1451.</mixed-citation><mixed-citation xml:lang="en">Pinto J.T., Suffoletto B.P., Berzin T.M. Prostatespecific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells. Clin Cancer Res. 1996; 2: 1445-1451.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Carter R.E., Feldman A.R., Coyle J.T. Prostatespecific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase. Proc. Natl. Acad. Sci USA. 1996; 93: 749-753.</mixed-citation><mixed-citation xml:lang="en">Carter R.E., Feldman A.R., Coyle J.T. Prostatespecific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase. Proc. Natl. Acad. Sci USA. 1996; 93: 749-753.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Halsted C.H., Ling E.H., Luthi-Carter R. Folylpolygamma-glutamate carboxypeptidase from pig jejunum: molecular characterization and relation to glutamate carboxypeptidase II. J. Biol. Chem. 1998; 273: 20417-20424.</mixed-citation><mixed-citation xml:lang="en">Halsted C.H., Ling E.H., Luthi-Carter R. Folylpolygamma-glutamate carboxypeptidase from pig jejunum: molecular characterization and relation to glutamate carboxypeptidase II. J. Biol. Chem. 1998; 273: 20417- 20424.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Bander N.H., Trabulsi E.J., Kostakoglu L. Targeting metastatic prostate cancer with radiolabeled monoclonal antibody J591 to the extracellular domain of prostate specific membrane antigen. J. Urol. 2003; 170: 1717-1721.</mixed-citation><mixed-citation xml:lang="en">Bander N.H., Trabulsi E.J., Kostakoglu L. Targeting metastatic prostate cancer with radiolabeled monoclonal antibody J591 to the extracellular domain of prostate specific membrane antigen. J. Urol. 2003; 170: 1717-1721.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Weijerman P.C., Zhang Y., Shen J. Expression of prostatic factors measured by reverse transcription polymerase chain reaction in human papillomavirus type 18 deoxyribonucleic acid immortalized prostate cell lines. Urology. 1998; 51: 657-662.</mixed-citation><mixed-citation xml:lang="en">Weijerman P.C., Zhang Y., Shen J. Expression of prostatic factors measured by reverse transcription polymerase chain reaction in human papillomavirus type 18 deoxyribonucleic acid immortalized prostate cell lines. Urology. 1998; 51: 657-662.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Leek J., Lench N., Maraj B. Prostate-specific membrane antigen: evidence for the existence of a second related human gene. Br. J. Cancer. 1995; 72: 583-588.</mixed-citation><mixed-citation xml:lang="en">Leek J., Lench N., Maraj B. Prostate-specific membrane antigen: evidence for the existence of a second related human gene. Br. J. Cancer. 1995; 72: 583-588.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Denekamp J., Dasu A., Waites A. Vasculature and microenvironmental gradients: the missing links in novel approaches to cancer therapy? Adv. Enz. Regul. 1998; 38: 281-299.</mixed-citation><mixed-citation xml:lang="en">Denekamp J., Dasu A., Waites A. Vasculature and microenvironmental gradients: the missing links in novel approaches to cancer therapy? Adv. Enz. Regul. 1998; 38: 281-299.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">O’Keefe D.S., Su S., Bacich D.J. Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene. Biochem. Biophys. Acta. 1998; 1443: 113-127.</mixed-citation><mixed-citation xml:lang="en">O’Keefe D.S., Su S., Bacich D.J. Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene. Biochem. Biophys. Acta. 1998; 1443: 113-127.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Rajasekaran S.A., Anilkumar G., Oshima E. A novel cytoplasmic tail MXXXL motif mediates the internalization of prostate-specific membrane antigen. Mol. Biol. Cell. 2003; 14: 4835-4845.</mixed-citation><mixed-citation xml:lang="en">Rajasekaran S.A., Anilkumar G., Oshima E. A novel cytoplasmic tail MXXXL motif mediates the internalization of prostate-specific membrane antigen. Mol. Biol. Cell. 2003; 14: 4835-4845.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Troyer J.K., Beckett M.L., Wright G.L., Jr. Detection and characterization of the prostate-specific membrane antigen (PSMA) in tissue extracts and body fluids. Int. J. Cancer. 1995; 62: 552-558.</mixed-citation><mixed-citation xml:lang="en">Troyer J.K., Beckett M.L., Wright G.L., Jr. Detection and characterization of the prostate-specific membrane antigen (PSMA) in tissue extracts and body fluids. Int. J. Cancer. 1995; 62: 552-558.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Troyer J.K., Beckett M.L., Wright G.L., Jr. Location of prostate-specific membrane antigen in the LNCaP prostate carcinoma cell line. Prostate. 1997; 30: 232-242.</mixed-citation><mixed-citation xml:lang="en">Troyer J.K., Beckett M.L., Wright G.L., Jr. Location of prostate-specific membrane antigen in the LNCaP prostate carcinoma cell line. Prostate. 1997; 30: 232-242.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Schulke N., Varlamova O.A., Donovan G.P. The homodimer of prostate-specific membrane antigen is a functional target for cancer therapy. Proc. Natl. Acad. Sci. USA. 2003; 100: 12590-12595.</mixed-citation><mixed-citation xml:lang="en">Schulke N., Varlamova O.A., Donovan G.P. The homodimer of prostate-specific membrane antigen is a functional target for cancer therapy. Proc. Natl. Acad. Sci. USA. 2003; 100: 12590-12595.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Horoszewicz J.S., Kawinski E., Murphy G.P. Monoclonal antibodies to a new antigenic marker in epithelial cells and serum of prostatic cancer patients. Anticancer Res. 1987; 7: 927-936.</mixed-citation><mixed-citation xml:lang="en">Horoszewicz J.S., Kawinski E., Murphy G.P. Monoclonal antibodies to a new antigenic marker in epithelial cells and serum of prostatic cancer patients. Anticancer Res. 1987; 7: 927-936.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Lopes A.D., Davis W.L., Rosenstraus M.J. Immunohistochemical and pharmacokinetic characterization of the site-specific immunoconjugate CYT-356 derived from antiprostate monoclonal antibody 7E11-C5. Cancer Res. 1990; 50: 6423-6429.</mixed-citation><mixed-citation xml:lang="en">Lopes A.D., Davis W.L., Rosenstraus M.J. Immunohistochemical and pharmacokinetic characterization of the site-specific immunoconjugate CYT-356 derived from antiprostate monoclonal antibody 7E11-C5. Cancer Res. 1990; 50: 6423-6429.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Silver D.A., Pellicer I., Fair W.R. Prostatespecific membrane antigen expression in normal and malignant human tissues. Clin. Cancer Res. 1997; 3: 81-85.</mixed-citation><mixed-citation xml:lang="en">Silver D.A., Pellicer I., Fair W.R. Prostatespecific membrane antigen expression in normal and malignant human tissues. Clin. Cancer Res. 1997; 3: 81-85.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Troyer J.K., Beckett M.L., Wright G.L., Jr. Detection and characterization of the prostate-specific membrane antigen (PSMA) in tissue extracts and body fluids. Int. J. Cancer. 1995; 62: 552-558.</mixed-citation><mixed-citation xml:lang="en">Troyer J.K., Beckett M.L., Wright G.L., Jr. Detection and characterization of the prostate-specific membrane antigen (PSMA) in tissue extracts and body fluids. Int. J. Cancer. 1995; 62: 552-558.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Chang S.S., Reuter V.E., Heston W.D., Gaudin P.B. Comparison of anti-prostate-specific membrane antigen antibodies and other immunomarkers in metastatic prostate carcinoma. Urology. 2001; 57: 1179-1183.</mixed-citation><mixed-citation xml:lang="en">Chang S.S., Reuter V.E., Heston W.D., Gaudin P.B. Comparison of anti-prostate-specific membrane antigen antibodies and other immunomarkers in metastatic prostate carcinoma. Urology. 2001; 57: 1179- 1183.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Kawakami M., Nakayama J. Enhanced expression of prostate-specific membrane antigen gene in prostate cancer as revealed by in situ hybridization. Cancer Res. 1997; 57: 2321-2324.</mixed-citation><mixed-citation xml:lang="en">Kawakami M., Nakayama J. Enhanced expression of prostate-specific membrane antigen gene in prostate cancer as revealed by in situ hybridization. Cancer Res. 1997; 57: 2321-2324.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Kuciel R., Bakalova A., Mazurkiewicz A., Bilska A., Ostrowski W. Is the subunit of prostatic phosphatase active? Reversible denaturation of prostatic acid phosphatase. Biochem. Int. 1990; 22: 329-334.</mixed-citation><mixed-citation xml:lang="en">Kuciel R., Bakalova A., Mazurkiewicz A., Bilska A., Ostrowski W. Is the subunit of prostatic phosphatase active? Reversible denaturation of prostatic acid phosphatase. Biochem. Int. 1990; 22: 329-334.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Lee H., Chu T.M., Li S.S., Lee C.L. Homodimer and heterodimer subunits of human prostatic acid phosphatase. Biochem. J. 1991; 277: 759-765.</mixed-citation><mixed-citation xml:lang="en">Lee H., Chu T.M., Li S.S., Lee C.L. Homodimer and heterodimer subunits of human prostatic acid phosphatase. Biochem. J. 1991; 277: 759-765.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Zelivianski S., Comeau D., Lin M.F. Cloning and analysis of the promoter activity of the human prostatic acid phosphatase gene. Biochem. Biophys. Res. Commun. 1998; 245: 108-112.</mixed-citation><mixed-citation xml:lang="en">Zelivianski S., Comeau D., Lin M.F. Cloning and analysis of the promoter activity of the human prostatic acid phosphatase gene. Biochem. Biophys. Res. Commun. 1998; 245: 108-112.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Vihko P., Kontturi M., Korhonen L.K. Purification of human prostatic acid phosphatase by affinity chromatography and isoelectric focusing. Part I. Clin. Chem. 1978; 24: 466-470.</mixed-citation><mixed-citation xml:lang="en">Vihko P., Kontturi M., Korhonen L.K. Purification of human prostatic acid phosphatase by affinity chromatography and isoelectric focusing. Part I. Clin. Chem. 1978; 24: 466-470.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Graddis T.J., McMahan C.J., Tamman J., Page K.J., Trager J.B. Prostatic acid phosphatase expression in human tissues. Int. J. Clin. Exp. Pathol. 2011; 4: 295- 306.</mixed-citation><mixed-citation xml:lang="en">Graddis T.J., McMahan C.J., Tamman J., Page K.J., Trager J.B. Prostatic acid phosphatase expression in human tissues. Int. J. Clin. Exp. Pathol. 2011; 4: 295- 306.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Goldfarb D.A., Stein B.S., Shamszadeh M., Petersen R.O. Age-related changes in tissue level of prostatic acid phosphatase and prostate specific antigen. J. Urol. 1986; 136: 1266-1269.</mixed-citation><mixed-citation xml:lang="en">Goldfarb D.A., Stein B.S., Shamszadeh M., Petersen R.O. Age-related changes in tissue level of prostatic acid phosphatase and prostate specific antigen. J. Urol. 1986; 136: 1266-1269.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Gunia S., Koch S., May M., Dietel M., Erbersdobler A. Expression of prostatic acid phosphatase (PSAP) in transurethral resection specimens of the prostate is predictive of histopathologic tumor stage in subsequent radical prostatectomies. Virchows. Arch. 2009; 454: 573-579.</mixed-citation><mixed-citation xml:lang="en">Gunia S., Koch S., May M., Dietel M., Erbersdobler A. Expression of prostatic acid phosphatase (PSAP) in transurethral resection specimens of the prostate is predictive of histopathologic tumor stage in subsequent radical prostatectomies. Virchows. Arch. 2009; 454: 573-579.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Zelivianski S., Glowacki R., Lin M.F. Transcriptional activation of the human prostatic acid phosphatase gene by NF-κB via a novel hexanucleotide-binding site. Nucleic. Acid. Res. 2004; 32: 3566-3580.</mixed-citation><mixed-citation xml:lang="en">Zelivianski S., Glowacki R., Lin M.F. Transcriptional activation of the human prostatic acid phosphatase gene by NF-κB via a novel hexanucleotide-binding site. Nucleic. Acid. Res. 2004; 32: 3566-3580.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Lin M.F., Garcia-Arenas R., Xia X.Z., Biela B., Lin F.F. The cellular level of prostatic acid phosphatase and the growth of human prostate carcinoma cells. Differentiation. 1994; 57: 143-149.</mixed-citation><mixed-citation xml:lang="en">Lin M.F., Garcia-Arenas R., Xia X.Z., Biela B., Lin F.F. The cellular level of prostatic acid phosphatase and the growth of human prostate carcinoma cells. Differentiation. 1994; 57: 143-149.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Merrick G.S., Butler W.M., Wallner K.E., Allen Z., DeFilippo J.L., Adamovich E. Enzymatic prostatic acid phosphatase in the clinical staging of patients diagnosed with prostate cancer. W. V. Med. J. 2005; 101: 116-119.</mixed-citation><mixed-citation xml:lang="en">Merrick G.S., Butler W.M., Wallner K.E., Allen Z., DeFilippo J.L., Adamovich E. Enzymatic prostatic acid phosphatase in the clinical staging of patients diagnosed with prostate cancer. W. V. Med. J. 2005; 101: 116-119.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Reiter R.E., Gu Z., Watabe T., Thomas G., Szigeti K., Davis E., Wahl M., Nisitani S., Yamashiro J., Le Beau M., Loda M., Witte O. Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer. Proc. Natl. Acad. Sci. USA. 1998; 95: 1735-1740.</mixed-citation><mixed-citation xml:lang="en">Reiter R.E., Gu Z., Watabe T., Thomas G., Szigeti K., Davis E., Wahl M., Nisitani S., Yamashiro J., Le Beau M., Loda M., Witte O. Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer. Proc. Natl. Acad. Sci. USA. 1998; 95: 1735-1740.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Reiter R.E., Gu Z., Watabe T., Thomas G., Szigeti K., Davis E., Wahl M., Nisitani S., Yamashiro J., Le Beau M., Loda M., Witte O. Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer. Proc. Natl. Acad. Sci. USA. 1998; 95: 1735-1740.</mixed-citation><mixed-citation xml:lang="en">Reiter R.E., Gu Z., Watabe T., Thomas G., Szigeti K., Davis E., Wahl M., Nisitani S., Yamashiro J., Le Beau M., Loda M., Witte O. Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer. Proc. Natl. Acad. Sci. USA. 1998; 95: 1735-1740.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Cunha A.C., Weigle B., Kiessling A., Bachmann M., Rieber E.P. Tissue-specificity of prostate specific antigens: comparative analysis of transcript levels in prostate nonprostate tissues. Cancer Lett. 2006; 236: 229-238.</mixed-citation><mixed-citation xml:lang="en">Cunha A.C., Weigle B., Kiessling A., Bachmann M., Rieber E.P. Tissue-specificity of prostate specific antigens: comparative analysis of transcript levels in prostate non-prostate tissues. Cancer Lett. 2006; 236: 229-238.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Ross S., Spencer S., Holcomb I., Tan C., Hongo J., Devaux B., Rangell L., Keller G., Schow P., Steeves R., Lutz R., Frantz G., Hillan K., Peale F., Tobin P., Eberhard D., Rubin M., Lasky L., Koeppen H. Prostate stem cell antigen as therapy target: tissue expression in vivo efficacy of an immunoconjugate. Cancer Res. 2002; 62: 2546-2553.</mixed-citation><mixed-citation xml:lang="en">Ross S., Spencer S., Holcomb I., Tan C., Hongo J., Devaux B., Rangell L., Keller G., Schow P., Steeves R., Lutz R., Frantz G., Hillan K., Peale F., Tobin P., Eberhard D., Rubin M., Lasky L., Koeppen H. Prostate stem cell antigen as therapy target: tissue expression in vivo efficacy of an immunoconjugate. Cancer Res. 2002; 62: 2546-2553.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Reiter R.E., Gu Z., Watabe T., Thomas G., Szigeti K., Davis E., Wahl M., Nisitani S., Yamashiro J., Le Beau M., Loda M., Witte O. Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer. Proc. Natl. Acad. Sci. USA. 1998; 95: 1735-1740.</mixed-citation><mixed-citation xml:lang="en">Reiter R.E., Gu Z., Watabe T., Thomas G., Szigeti K., Davis E., Wahl M., Nisitani S., Yamashiro J., Le Beau M., Loda M., Witte O. Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer. Proc. Natl. Acad. Sci. USA. 1998; 95: 1735-1740.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Bluemn E.G., Nelson P.S. The androgen/androgen receptor axis in prostate cancer. Curr. Opin. Oncol. 2012; 24: 251-257. https://doi.org/10.1097/CCO.0b013e32835105b3.</mixed-citation><mixed-citation xml:lang="en">Bluemn E.G., Nelson P.S. The androgen/ androgen receptor axis in prostate cancer. Curr. Opin. Oncol. 2012; 24: 251-257. https://doi.org/10.1097/CCO.0b013e32835105b3.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Ziaran S., Novakova Z.V., Böhmer D., Danišovič L. Biomarkers for determination prostate cancer: Implication for diagnosis and prognosis. Neoplasma. 2015; 62: 683- 691. https://doi.org/10.4149/neo_2015_082</mixed-citation><mixed-citation xml:lang="en">Ziaran S., Novakova Z.V., Böhmer D., Danišovič L. Biomarkers for determination prostate cancer: Implication for diagnosis and prognosis. Neoplasma. 2015; 62: 683- 691. https://doi.org/10.4149/neo_2015_082</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Kasivisvanathan V., Rannikko A.S., Borghi M., Panebianco V., Mynderse L.A., Vaarala M.H., Briganti A., Budäus L., Hellawell G., Hindley R.G., et al. MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis. N. Engl. J. Med. 2018; 378: 1767-1777.</mixed-citation><mixed-citation xml:lang="en">Kasivisvanathan V., Rannikko A.S., Borghi M., Panebianco V., Mynderse L.A., Vaarala M.H., Briganti A., Budäus L., Hellawell G., Hindley R.G., et al. MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis. N. Engl. J. Med. 2018; 378: 1767-1777.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Albright F., Stephenson R.A., Agarwal N., Teerlink C.C., Lowrance W.T., Farnham J.M., Albright L.A.C. Prostate cancer risk prediction based on complete prostate cancer family history. Prostate. 2015; 75: 390-398.</mixed-citation><mixed-citation xml:lang="en">Albright F., Stephenson R.A., Agarwal N., Teerlink C.C., Lowrance W.T., Farnham J.M., Albright L.A.C. Prostate cancer risk prediction based on complete prostate cancer family history. Prostate. 2015; 75: 390- 398.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Prando A. Diffusion-weighted MRI of peripheral zone prostate cancer: Comparison of tumor apparent diffusion coefficient with Gleason score and percentage of tumor on core biopsy. Int. Braz. J. Urol. 2010; 36: 504-517.</mixed-citation><mixed-citation xml:lang="en">Prando A. Diffusion-weighted MRI of peripheral zone prostate cancer: Comparison of tumor apparent diffusion coefficient with Gleason score and percentage of tumor on core biopsy. Int. Braz. J. Urol. 2010; 36: 504-517.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
