medecolМедицина и экологияMedicine and ecology2305-60452305-6053Карагандинский медицинский университетmedecol-90Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSСОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О МЕТАБОЛИЗМЕ ЖЕЛЕЗАMODERN VIEWS ON IRON METABOLISMВазенмиллерД. В.VazenmillerD. V.noemail@neicon.ruМуравлеваЛ. Е.MuravlyovaL. Ye.noemail@neicon.ruПонамареваО. А.PonamaryovaO. A.noemail@neicon.ruКомличенкоЭ. В.KomlichenkoYe. V.noemail@neicon.ruАмирбековаЖ. Т.AmirbekovaZh. T.noemail@neicon.ruБащжановаЖ. О.BaschzhanovaZh. O.noemail@neicon.ruНАО «Медицинский университет Караганды»КазахстанKaraganda medical universityKazakhstanИнститут перинатологии и педиатрии ФГБУ «НМИЦ им. В. А. Алмазова»РоссияInstitute of perinatology and pediatricsRussian Federation201907092021011522Copyright © Вазенмиллер Д.В., Муравлева Л.Е., Понамарева О.А., Комличенко Э.В., Амирбекова Ж.Т., Бащжанова Ж.О., 20212021Вазенмиллер Д.В., Муравлева Л.Е., Понамарева О.А., Комличенко Э.В., Амирбекова Ж.Т., Бащжанова Ж.О.Vazenmiller D.V., Muravlyova L.Y., Ponamaryova O.A., Komlichenko Y.V., Amirbekova Z.T., Baschzhanova Z.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medecol.qmu.kz/jour/article/view/90

В представленном обзоре литературы проведен анализ современных представлений о метаболизме железа. Одним из перспективных направлений исследования является детальное изучение сигнальных механизмов, ведущих к активации гепсидина, а также определение и изучение регуляторных взаимосвязей между системным и клеточным метаболизмом железа. Остаются до конца не изученными механизмы транспорта железа через мембраны внутриклеточных органелл. Исследования в этом направлении имеют не только биологическое, но медицинское значение. Так, ось гепсидин-ферропортин позиционируется как привлекательная мишень для разработки лекарств. Предполагается, что IRP1 и IRP2 участвуют не только в регуляции метаболизма железа, но и играют самостоятельную роль в механизмах развития рака.

In the present review of the literature, an analysis of modern ideas about iron metabolism is carried out. As promising areas of research are a detailed study of signaling mechanisms leading to hepcidin activation. The current direction is the definition and study of the regulatory relationships between systemic and cellular iron metabolism. The mechanisms of iron transport through the membranes of intracellular organelles are also not fully understood. Research in this direction has not only biological, but medical value. So, the axis hepcidin-ferroportin is positioned as an attractive target for drug development. It is assumed that IRP1 and IRP2 are involved not only in the regulation of iron metabolism, but also play an independent role in the mechanisms of cancer development.

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The authors declare that there are no conflicts of interest present.