medecolМедицина и экологияMedicine and ecology2305-60452305-6053Карагандинский медицинский университетmedecol-89Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSЭФФЕКТИВНОСТЬ АДЪЮВАНТНОЙ ТЕРАПИИ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫEFFICIENCY OF BREAST CANCER ADJUVANT THERAPYЖумакаеваС. С.ZhumakayevaS. S.noemail@neicon.ruЖумакаеваА. М.ZhumakayevaA. M.noemail@neicon.ruКабилдинаН. А.KabildinaN. A.noemail@neicon.ruМедицинский университет КарагандыКазахстанKaraganda medical universityKazakhstan20190709202101814Copyright © Жумакаева С.С., Жумакаева А.М., Кабилдина Н.А., 20212021Жумакаева С.С., Жумакаева А.М., Кабилдина Н.А.Zhumakayeva S.S., Zhumakayeva A.M., Kabildina N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medecol.qmu.kz/jour/article/view/89

Авторами представлен литературный обзор о направлениях современной адъювантной терапии рака молочной железы. Применение адъювантной химиотерапии, таргетной и гормонотерапии повышает показатели безрецидивной и общей выживаемости больных раком молочной железы. Данные литературы свидетельствуют о целесообразности совместного назначения химио- и таргетной или химио- и гормонотерапии у больных местно-распространенным раком молочной железы. Авторы считают, что адъювантная терапия является достижением в лечении больных раком молочной железы, ее оптимальное применение значимо повышает показатели общей и безрецидивной выживаемости. Несмотря на имеющиеся стандартные схемы химиотерапии, зарекомендовавшие себя высокой эффективностью, безрецидивностью и стабильными показателями выживаемости, медицина не стоит на месте, и ученые ежегодно пытаются разработать новые химио-таргетные препараты, обладающие меньшей токсичностью, которые в скором времени станут приоритетным направлением в адъювантном лечении.

The authors presented a literature review on the directions of modern adjuvant therapy for breast cancer. The use of adjuvant chemotherapy, targeted and hormone therapy increases the rates of relapse-free and overall survival of patients with breast cancer. The literature data indicate the feasibility of co-prescribing chemotherapy and targeted or chemotherapy and hormone therapy in patients with locally advanced breast cancer. The authors believe that adjuvant therapy is an achievement in the treatment of patients with breast cancer, its optimal use significantly increases the overall and relapse-free survival rates. Despite the standard chemotherapy regimens that have proven to be highly effective, relapse-free, and stable survival rates, medicine does not stand still, and scientists each year try to develop new chemotherapy-targeted drugs with less toxicity, which will soon become a priority in the adjuvant treatment.

рак молочной железыадъювантная химиотерапиятаргетная терапиясүт безі обырыадъювантный химиотерапиямақсатты терапияbreast canceradjuvant chemotherapytargeted therapyReferencesБелохвостова А. С. Таргетная терапия в лечении HER2-позитивного рака молочной железы /А. С Белохвостова, И. А. Смирнова, А. А. Енилеева //Сиб. онкол. журн. - 2013. - №2 (56). - С. 84-88.Белохвостова А. С. Таргетная терапия в лечении HER2-позитивного рака молочной железы /А. С Белохвостова, И. А. Смирнова, А. А. Енилеева //Сиб. онкол. журн. - 2013. - №2 (56). - С. 84-88.Жукова Л. Г. Адъювантная терапия трастузумабом при ранних стадиях рака молочной железы: 12 или 24 месяца (по данным ESMO, Вена, октябрь 2012) /Л. Г. Жукова, М. Р. Личиницер //Фарматека. - 2012. - №18. - С. 69-70.Жукова Л. Г. Адъювантная терапия трастузумабом при ранних стадиях рака молочной железы: 12 или 24 месяца (по данным ESMO, Вена, октябрь 2012) /Л. Г. Жукова, М. Р. Личиницер //Фарматека. - 2012. - №18. - С. 69-70.Манихас А. Г. Рак молочной железы. Химиотерапия и таргетная терапия /А. Г. Манихас, В. В. Семиглазов, В. Ф. Семиглазов. -М.: 2012. - 360 с.Манихас А. Г. Рак молочной железы. Химиотерапия и таргетная терапия /А. Г. Манихас, В. В. Семиглазов, В. Ф. Семиглазов. -М.: 2012. - 360 с.Abdoli G. Breast cancer diagnosis and mortality by tumor stage and migration background in a nationwide cohort study in Sweden / G. Abdoli, M. Bottai, T. Moradi //Breast. - 2017. -V. 31. - P. 57-65.Abdoli G. Breast cancer diagnosis and mortality by tumor stage and migration background in a nationwide cohort study in Sweden / G. Abdoli, M. Bottai, T. Moradi //Breast. - 2017. -V. 31. - P. 57-65.Alba E. Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer /E. Alba, F. Andre, C. L. Arteaga //N. Engl. J. Med. - 2016. - V. 375 (18). - P. 1738-1748.Alba E. Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer /E. Alba, F. Andre, C. L. Arteaga //N. Engl. J. Med. - 2016. - V. 375 (18). - P. 1738-1748.Anampa J. Progress in adjuvant chemotherapy for breast cancer: an overview /J. Anampa, D. Makower, J. A. Sparano //BMC Med. -2015. - V. 13. - P. 195.Anampa J. Progress in adjuvant chemotherapy for breast cancer: an overview /J. Anampa, D. Makower, J. A. Sparano //BMC Med. -2015. - V. 13. - P. 195.Azambuja E. Herceptin Adjuvant (HERA) Trial Study Team. Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4 -year follow-up of a randomised controlled trial / E. Azambuja, L. Gianni, U. Dafni, R. D. Gelber et al. //Lancet Oncol. - 2011. - V. 12 (3). - P. 236244.Azambuja E. Herceptin Adjuvant (HERA) Trial Study Team. Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4 -year follow-up of a randomised controlled trial / E. Azambuja, L. Gianni, U. Dafni, R. D. Gelber et al. //Lancet Oncol. - 2011. - V. 12 (3). - P. 236244.Barba M. Molecular profiles of screen detected vs. symptomatic breast cancer and their impact on survival: results from a clinical series / M. Barba, A. Crispo, G. D'Aiuto et al. //BMC Cancer. - 2013. - V. 13. - P. 15.Barba M. Molecular profiles of screen detected vs. symptomatic breast cancer and their impact on survival: results from a clinical series / M. Barba, A. Crispo, G. D'Aiuto et al. //BMC Cancer. - 2013. - V. 13. - P. 15.Barnett J. Impact on survival of time from definitive surgery to initiation of adjuvant chemotherapy for early-stage breast cancer /J. Barnett, K. Gelmon, C. Lohrisch //Clin. Oncol. -2006. - V. 24. - P. 4888-4894.Barnett J. Impact on survival of time from definitive surgery to initiation of adjuvant chemotherapy for early-stage breast cancer /J. Barnett, K. Gelmon, C. Lohrisch //Clin. Oncol. -2006. - V. 24. - P. 4888-4894.Blows F. Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies /F. Blows, K. E. Driver, M. K. Schmidt //PLoS Med. - 2010. - V. 7 (5): e1000279.Blows F. Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies /F. Blows, K. E. Driver, M. K. Schmidt //PLoS Med. - 2010. - V. 7 (5): e1000279.Boer K. The cyclin - dependent kinase 4/6 inibitor palbociclibin combination with letrozole versus letrozole alone as first - line treatment of oestrogen receptor - positive, HER2-negative, advanced breast cancer (PALOMA-1/ TRIO-18): a randomized phase study /K. Boer, I. M. Bondarenko, J. P. Crown //The Lancet Oncology. - 2015. - V. 16. - P. 25-35.Boer K. The cyclin - dependent kinase 4/6 inibitor palbociclibin combination with letrozole versus letrozole alone as first - line treatment of oestrogen receptor - positive, HER2-negative, advanced breast cancer (PALOMA-1/ TRIO-18): a randomized phase study /K. Boer, I. M. Bondarenko, J. P. Crown //The Lancet Oncology. - 2015. - V. 16. - P. 25-35.Boller E. Palliative systemic therapy and overall survival of 1,395 patients with advanced breast cancer e Results from the prospective German TMK cohort study /E. Boller, T. Fietz, M. Janicke //The Breast. - 2017. - V. 34. - 122e130.Boller E. Palliative systemic therapy and overall survival of 1,395 patients with advanced breast cancer e Results from the prospective German TMK cohort study /E. Boller, T. Fietz, M. Janicke //The Breast. - 2017. - V. 34. - 122e130.Bonetti J. Burdens and benefits of adjuvant cyclophosphamide, methotrexate, and fluorouracil and tamoxifen for elderly patients with breast Cancer: the internatio /J. Bonetti, J. Bernhard, M. Castiglione-Gertsch //Official journal of the American Society of Clinical Oncology. -2009. - V. 18. - P. 1412-1422.Bonetti J. Burdens and benefits of adjuvant cyclophosphamide, methotrexate, and fluorouracil and tamoxifen for elderly patients with breast Cancer: the internatio /J. Bonetti, J. Bernhard, M. Castiglione-Gertsch //Official journal of the American Society of Clinical Oncology. -2009. - V. 18. - P. 1412-1422.Bonifazi M. Long term survival of HER2-positive early breast cancer treated with trastuzumab-based adjuvant regimen: A large cohort study from clinical practice /M. Bonifazi, M. Franchi //The Breast. - 2014. - V. 23. - P. 573-578.Bonifazi M. Long term survival of HER2-positive early breast cancer treated with trastuzumab-based adjuvant regimen: A large cohort study from clinical practice /M. Bonifazi, M. Franchi //The Breast. - 2014. - V. 23. - P. 573-578.Brewer T. M. Long-term treatment efficacy in primary inflammatory breast cancer by hormonal receptor- and HER2- defined subtypes / T. M. Brewer, H. Masuda, D. D. Liu //Ann. Oncol. Off J. Eur. Soc. Med. Oncol. - 2014. - V. 25 (2). -P. 384-391.Brewer T. M. Long-term treatment efficacy in primary inflammatory breast cancer by hormonal receptor- and HER2- defined subtypes / T. M. Brewer, H. Masuda, D. D. Liu //Ann. Oncol. Off J. Eur. Soc. Med. Oncol. - 2014. - V. 25 (2). -P. 384-391.Burstein H. J. American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptorpositive breast cancer: status report. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials //Lancet. -2005. - V. 381. - P. 805-816.Burstein H. J. American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptorpositive breast cancer: status report. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials //Lancet. -2005. - V. 381. - P. 805-816.Cameron D. 11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trial /D. Cameron, R. D. Gelber, M. J. Piccart-Gebhart //Lancet. - 2017. - V. 389. - P. 1195-1205.Cameron D. 11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trial /D. Cameron, R. D. Gelber, M. J. Piccart-Gebhart //Lancet. - 2017. - V. 389. - P. 1195-1205.Caroline S. Breast cancer in young women: have the prognostic implications of breast cancer subtypes changed over time? /S. Caroline, V. David, T. Scott //Breast Cancer. Res. Treat. - 2014. - V. 147 (3). - P. 617-629.Caroline S. Breast cancer in young women: have the prognostic implications of breast cancer subtypes changed over time? /S. Caroline, V. David, T. Scott //Breast Cancer. Res. Treat. - 2014. - V. 147 (3). - P. 617-629.Chavez-MacGregor M. Delayed Initiation of Adjuvant Chemotherapy Among Patients With Breast Cancer /M. Chavez-MacGregor, C. A. Clarke, S. H. Giordano //JAMA Oncol. - 2016. - V. 2. - P. 322-329.Chavez-MacGregor M. Delayed Initiation of Adjuvant Chemotherapy Among Patients With Breast Cancer /M. Chavez-MacGregor, C. A. Clarke, S. H. Giordano //JAMA Oncol. - 2016. - V. 2. - P. 322-329.Cold S. Does timing of adjuvant chemotherapy influence the prognosis after early breast cancer? Results of the Danish Breast Cancer Cooperative Group (DBCG) /S. Cold, M. During, M. Ewertz //British journal of cancer. - 2005. - V. 93. - P. 627-632.Cold S. Does timing of adjuvant chemotherapy influence the prognosis after early breast cancer? Results of the Danish Breast Cancer Cooperative Group (DBCG) /S. Cold, M. During, M. Ewertz //British journal of cancer. - 2005. - V. 93. - P. 627-632.Conant L. Predictive factors and patterns of recurrence in patients with triple negative breast cancer /L. Conant, L. Steward, F. Gao // Ann. Surg. Oncol. - 2014. - V. 21 (7). - P. 21652171.Conant L. Predictive factors and patterns of recurrence in patients with triple negative breast cancer /L. Conant, L. Steward, F. Gao // Ann. Surg. Oncol. - 2014. - V. 21 (7). - P. 21652171.DeSantis C. E. Cancer treatment and survivorship statistics, 2014 /C. E. DeSantis, C. C. Lin, J. L. Kramer //CA Cancer J. Clin. - 2014. - V. 64. - P. 252-271.DeSantis C. E. Cancer treatment and survivorship statistics, 2014 /C. E. DeSantis, C. C. Lin, J. L. Kramer //CA Cancer J. Clin. - 2014. - V. 64. - P. 252-271.Dikshit R. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 /R. Dikshit, S. Eser, J. Ferlay //Int. J. Cancer. - 2015. - №36 (5). - Р. 359-386.Dikshit R. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 /R. Dikshit, S. Eser, J. Ferlay //Int. J. Cancer. - 2015. - №36 (5). - Р. 359-386.Du X. L. Impact of timing of adjuvant chemotherapy initiation and completion after surgery on racial disparities in survival among women with breast cancer /X. L. Du, L. Franzini, C. C. Liu //Med. Oncol. - 2013. - V. 30. - P. 419.Du X. L. Impact of timing of adjuvant chemotherapy initiation and completion after surgery on racial disparities in survival among women with breast cancer /X. L. Du, L. Franzini, C. C. Liu //Med. Oncol. - 2013. - V. 30. - P. 419.Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials //Lancet. - 2005. - V. 365. - P. 1687-1717.Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials //Lancet. - 2005. - V. 365. - P. 1687-1717.Fan L. Influence of delayed initiation of adjuvant chemotherapy on breast cancer survival is subtype-dependent /K. D. Yu, L. X. Qiu, H. Ling //Oncotarget. - 2017. - V. 8. - P. 4654946556.Fan L. Influence of delayed initiation of adjuvant chemotherapy on breast cancer survival is subtype-dependent /K. D. Yu, L. X. Qiu, H. Ling //Oncotarget. - 2017. - V. 8. - P. 4654946556.Ho M. Y.Presentation and management of docetaxel-related adverse effects in patients with breast cancer /M. Y. Ho, J. R. Mackey // Cancer Manag. Res. - 2014. - V. 6. - 253e9.Ho M. Y.Presentation and management of docetaxel-related adverse effects in patients with breast cancer /M. Y. Ho, J. R. Mackey // Cancer Manag. Res. - 2014. - V. 6. - 253e9.Jemal A. Cancer statistics, 2018 /A. Jemal, K. D. Miller, R. L. Siegel //CA Cancer J. Clin. - 2018. - V. 68 (1). - P. 7-30.Jemal A. Cancer statistics, 2018 /A. Jemal, K. D. Miller, R. L. Siegel //CA Cancer J. Clin. - 2018. - V. 68 (1). - P. 7-30.Karaki K. Significant association between low baseline neutrophil to lymphocyte ratio and improved progression free survival of patients with locally advanced or metastatic breast cancer treated with eribulin but not with nab paclitaxel /K. Karaki, A. Bun, Y. Fujimoto // Clinical Breast Cancer. - 2018. - V. 18. - P. 400409.Karaki K. Significant association between low baseline neutrophil to lymphocyte ratio and improved progression free survival of patients with locally advanced or metastatic breast cancer treated with eribulin but not with nab paclitaxel /K. Karaki, A. Bun, Y. Fujimoto // Clinical Breast Cancer. - 2018. - V. 18. - P. 400409.Konig J. Adherence to treatment guidelines and survival in triple-negative breast cancer: a retrospective multi-center cohort study with 9156 patients /J. Konig, L. Schwentner, A. Wockel //BMC Cancer. - 2013. - V. 13 (1). - P. 487.Konig J. Adherence to treatment guidelines and survival in triple-negative breast cancer: a retrospective multi-center cohort study with 9156 patients /J. Konig, L. Schwentner, A. Wockel //BMC Cancer. - 2013. - V. 13 (1). - P. 487.Visvanathan К. Tao Long term side effects of adjuvant chemotherapy in patients with early breast cancer /К. Visvanathan, J. Jessica // The Breast. - 2015. - V. 24. - P. 149-153.Visvanathan К. Tao Long term side effects of adjuvant chemotherapy in patients with early breast cancer /К. Visvanathan, J. Jessica // The Breast. - 2015. - V. 24. - P. 149-153.Sandoval A. C. Her2-Positive Breast /A. C. Sandoval, R. Mahtani, M. Jahanzeb //FACP. Cancer. - 2019. - V. 34. - P. 107-118.Sandoval A. C. Her2-Positive Breast /A. C. Sandoval, R. Mahtani, M. Jahanzeb //FACP. Cancer. - 2019. - V. 34. - P. 107-118.

The authors declare that there are no conflicts of interest present.