medecolМедицина и экологияMedicine and ecology2305-60452305-6053Карагандинский медицинский университет10.59598/ME-2305-6045-2024-113-4-91-102medecol-806Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEСравнительная эффективность внутрисуставной инъекции PRP и имплантации гепарин-конъюгированного фибринового гидрогеля при остеоартрозе коленного суставаComparative effectiveness of intraarticular injection of PRP and implantation of heparin-conjugated fibrin hydrogel in osteoarthrosis of the knee jointТоктаровТ. А.ToktarovT. A.

Тусипхан Абдыгалиевич Токтаров

010000, г. Астана, пр. Абылайхана, 15а

010000, г. Астана, пр. Бейбітшілік 49а

Tussipkhan Abdygalyuly Toktarov

010000, Astana, Abylaikhan av., 15а

010000, Astana, Beibitshilik st., 49a

info@nscto.kzРаймагамбетовЕ. К.RaimagambetovY. K.

010000, г. Астана, пр. Абылайхана, 15а

010000, Astana, Abylaikhan av., 15а

info@nscto.kzБалбосыновБ. Е.BalbossynovB. Y.

010000, г. Астана, пр. Абылайхана, 15а

010000, Astana, Abylaikhan av., 15а

info@nscto.kzСагиноваД. А.SaginovaD. A.

010000, г. Астана, пр. Абылайхана, 15а

010000, Astana, Abylaikhan av., 15а

info@nscto.kzОгайВ. Б.OgayV. B.

010000, г. Астана, Кургальжинское шоссе, здание 13/5

010000, Kurgalzhynskoye road, 13/5

info@biocenter.kzБатпенА. Н.BatpenA. N.

010000, г. Астана, пр. Абылайхана, 15а

010000, Astana, Abylaikhan av., 15а

info@nscto.kzАбилмажиновМ. Т.AbilmazhinovM. T.

010000, г. Астана, пр. Бейбітшілік 49а

010000, Astana, Beibitshilik st., 49a

mail@amu.kzКаркынК.KarkynK.

071400, Область Абай, г. Семей, ул. Мәңгілік Ел, 11

071400, Semey, Mangilik El st., 11

semey@abu.edu.kz«Национальный научный центр травматологии и ортопедии имени Академика Н. Д. Батпенова»; Кафедра травматологии и ортопедии НАО «Медицинский университет Астана»КазахстанNational Scientific Center of Traumatology and Orthopedics named after Academician N. D. Batpenov; Department of Traumatology and Orthopedics NpJSC «Astana Medical University»Kazakhstan«Национальный научный центр травматологии и ортопедии имени Академика Н. Д. Батпенова»КазахстанNational Scientific Center of Traumatology and Orthopedics named after Academician N. D. BatpenovKazakhstan«Национальный центр биотехнологии»КазахстанNational Center for BiotechnologyKazakhstanКафедра травматологии и ортопедии НАО «Медицинский университет Астана»КазахстанDepartment of Traumatology and Orthopedics NpJSC «Astana Medical University»KazakhstanAlikhan Bokeikhan UniversityКазахстанAlikhan Bokeikhan UniversityKazakhstan2024220120250491102Copyright © Токтаров Т.А., Раймагамбетов Е.К., Балбосынов Б.Е., Сагинова Д.А., Огай В.Б., Батпен А.Н., Абилмажинов М.Т., Каркын К., 20242024Токтаров Т.А., Раймагамбетов Е.К., Балбосынов Б.Е., Сагинова Д.А., Огай В.Б., Батпен А.Н., Абилмажинов М.Т., Каркын К.Toktarov T.A., Raimagambetov Y.K., Balbossynov B.Y., Saginova D.A., Ogay V.B., Batpen A.N., Abilmazhinov M.T., Karkyn K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medecol.qmu.kz/jour/article/view/806

Цель исследования. Статья посвящена актуальному направлению современной ортопедии - хирургическому лечению локальных полнослойных дефектов гиалинового хряща коленного сустава. Данная патология диагностируется у 5-10% пациентов с заболеваниями и травмами коленного сустава.Материалы и методы. Авторы статьи представили одну из самых современных и доступных технологий восстановления хрящевых дефектов - имплантацию гепарин-конъюгированного фибринового гидрогеля. Данная методика операции была выполнена у 38 пациентов. В статье представлены показания и техника операции, критерии оценки результатов лечения.Результаты и обсуждение. Исходы лечения в сроки до 2 лет изучены у 38 пациентов. Хорошие результаты лечения отмечены у 33 пациентов. Во всех случаях достигнуто качественное восстановление и регенерация хрящевой поверхности мыщелков бедренной кости.Заключение. Анализ результатов лечения пациентов после имплантации гепарин-конъюгированного фибринового гидрогеля позволяет авторам статьи рекомендовать данную методику к широкому применению в клинической практике.

Aim of the study. The article is devoted to the current trend of modern orthopedics – the surgical treatment of local full-thickness defects in the hyaline cartilage of the knee joint. This pathology is diagnosed in 5-10% of patients with diseases and injuries of the knee joint.Materials and methods. The authors of the article presented one of the most modern and available technologies for the restoration of cartilage defects – the implantation of Heparin-Conjugated Fibrin Hydrogel. This operation technique was used in 38 patients. The article presents the indications and technique of surgery, criteria for evaluating treatment outcomes.Results and discussion. Treatment outcomes in terms of up to 2 years were studied in 38 patients. Good treatment results were observed in 33 patients. In all cases, high-quality and regeneration of the cartilaginous surface of the femoral condyles was achieved.Conclusion. Analysis of the outcomes of treatment of patients after implantation implantation of Heparin- Conjugated Fibrin Hydrogel allows the authors of the article to recommend this technique for widespread use in clinical practice.

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The authors declare that there are no conflicts of interest present.