medecolМедицина и экологияMedicine and ecology2305-60452305-6053Карагандинский медицинский университет10.59598/ME-2305-6045-2024-111-2-57-63medecol-687Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEТревожно-депрессивные расстройства после COVID-19Anxiety-depressive disorders after COVID-19КульбаеваЗ. Д.KulbayevaZ. D.

Зейне Дархановна Кульбаева – магистр медицины, преподаватель-исследователь кафедры неврологии, психиатрии и реабилитологии 

100008, г. Караганда, ул. Гоголя, 40

Zeine Darkhanovna Kulbayeva – research-teacher of the Department of Neurology, Psychiatry and Rehabilitation Sciences, master of medicine

100008, Karaganda, Gogol street, 40

zkulbaeva@qmu.kzКалиеваШ. С.KaliyevaSh. S.

100008, г. Караганда, ул. Гоголя, 40

100008, Karaganda, Gogol street, 40

info@qmu.kzКлюевД. А.KlyuyevD. A.

100008, г. Караганда, ул. Гоголя, 40

100008, Karaganda, Gogol street, 40

info@qmu.kzТулеутаеваС. Т.TuleutayevaS. T.

100008, г. Караганда, ул. Гоголя, 40

100008, Karaganda, Gogol street, 40

info@qmu.kzНекоммерческое акционерное общество «Медицинский университет Караганды»КазахстанNon-profit joint-stock company «Karaganda Medical University»Kazakhstan202430072024025763Copyright © Кульбаева З.Д., Калиева Ш.С., Клюев Д.А., Тулеутаева С.Т., 20242024Кульбаева З.Д., Калиева Ш.С., Клюев Д.А., Тулеутаева С.Т.Kulbayeva Z.D., Kaliyeva S.S., Klyuyev D.A., Tuleutayeva S.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medecol.qmu.kz/jour/article/view/687

Окислительный стресс является одной из основных причин дисфункции и гибели нейронов, главным образом из-за избыточного образования реактивных форм кислорода и истощения запасов антиоксидантов. Окислительный стресс характеризуется дисбалансом между производством реактивных форм кислорода (ROS) и антиоксидантными защитными механизмами организма. Этот процесс вовлечен в возникновение и развитие многих неврологических заболеваний. Авторы проанализировали и обобщили результаты исследований, показавших связь неврологических заболеваний, таких как инсульт, болезнь Паркинсона и другие неврологические заболевания, с избыточным образованием продуктов окислительного стресса, проанализировали взаимосвязи между окислительным стрессом и рядом неврологических заболеваний, оценили лежащие в их основе механизмы и потенциальные терапевтические последствия. Целью исследования было определение уровня тревожно-депрессивных расстройств среди пациентов, перенесших COVID-19. Были обследованы 90 человек, отобранных в соответствии с критериями включения и исключения. Для оценки высших нервных функций использовали госпитальные шкалы HADS I, HADS II, шкалу депрессии Бека. Проведенное исследование не выявило четкой связи между наличием вируса в организме и тревожно-депрессивными проявлениями у пациентов, что может свидетельствовать о том, что основная причина расстройств кроется в социальных аспектах пандемии.

The 2019 coronavirus (COVID-19) pandemic has reached more than 194 million people as of July 26, 2021, and continues to spread worldwide. During the course of the long pandemic, evidence of damage to various organs and systems, such as the nervous system and parts of it, began to emerge. Oxidative stress is one of the main causes of neuronal dysfunction and death, mainly due to excessive formation of reactive oxygen species and depletion of antioxidant reserves. Oxidative stress is characterized by an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense mechanisms of the body. This process is involved in the onset and development of many neurological diseases. In this review, we analyzed and summarized the results of studies showing the association of neurological diseases, such as stroke, Parkinson's disease, and other neurological diseases, with excessive formation of oxidative stress products. This article aims to provide an overview of the relationship between oxidative stress and a range of neurological conditions, shedding light on the underlying mechanisms and potential therapeutic implications. Objective of the study was to determine the level of anxiety-depressive disorders among patients who underwent COVID-19. 90 people were examined and selected according to inclusion and exclusion criteria. To assess higher nervous functions, we used the hospital scales HADS I, HADS II, Beck depression scale. To date, our study has not found a clear link between the virus in the body and anxiety-depressive manifestations in patients, which may suggest that the main cause of the disorders lies in the social aspects of the pandemic. 

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The authors declare that there are no conflicts of interest present.