medecolМедицина и экологияMedicine and ecology2305-60452305-6053Карагандинский медицинский университетmedecol-64Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEМОЛЕКУЛЯРНЫЕ ОНКОМАРКЕРЫ ПРИ ХРОНИЧЕСКОЙ ИНТОКСИКАЦИИ И ВИРУСНОЙ ИНФЕКЦИИMOLECULAR CANCER MARKERS WI T H CHRON I C INTOXI C ATION AND VIRAL INFECTIONАхмалтдиноваЛ. Л.AkhmaltdinovaL. L.noemail@neicon.ruАзизовИ. С.AzizovI. S.noemail@neicon.ruАвдиенкоО. В.AvdienkoO. V.noemail@neicon.ruКарагандинский государственный медицинский университетКазахстанKaraganda state medical universityKazakhstanНИИ антимикробной химиотерапииКазахстанResearch institute of antimicrobial chemotherapyKazakhstan201807092021036064Copyright © Ахмалтдинова Л.Л., Азизов И.С., Авдиенко О.В., 20212021Ахмалтдинова Л.Л., Азизов И.С., Авдиенко О.В.Akhmaltdinova L.L., Azizov I.S., Avdienko O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medecol.qmu.kz/jour/article/view/64

Патогенез связи фоновой патологии и диагностической значимости онкологии представляет большой интерес. Целью исследования стало изучения уровня молекулярных онкомаркеров у ВИЧ-инфицированных с фоном парентеральных форм наркотических средств и без отягощающего фона. Для исследования использовали сыворотку 30 ВИЧ+ потребителей инъекционных форм наркотиков, 30 ВИЧ+ пациентов без фона наркотической зависимости. Контрольную группу составили 23 здоровых человека, отрицательных при скрининге на ВИЧ-инфекцию, группу сравнения - 23 пациента с наркотической зависимостью. Методом xMap на Биоплекс 3Д с применением набора Cancer Biomarcers panel были исследованы следующие маркеры: sHER-2, sEGFR, sIL-6Ra, FGF, sVEGFR-1, sVEGFR-2, PECAM-1, PDGF AB/BB, G-SCF, sTIE-2, SCF, остеопонтин. Обнаружено увеличение уровней sHER-2, sEGRf, sIL-6RA, sVEGfr-2, PECAM-1, sTIE-2 у всех ВИЧ-инфицированных пациентов. Маркеры SCF и FGF повышены только у ВИЧ+ потребителей инъекционных форм наркотиков. Потребители инъекционных форм наркотиков имеют повышенный уровень провоспалительных маркеров sIL-6RA, PECAM1, остеопонтин и уровень HER-2. Таким образом, исследование биомаркеров канцерогенеза имеет свои особенности у пациентов с предсуществующей инфекцией и интоксикацией.

Pathogenesis of the connection infection, intoxication and cancer is the interesting and actual problem for research. The aim of the study was to investigate the level of cancer biomarkers in HIV-infected patients with a background of narcotic drugs parenteral forms use and in HIV-infected patients without aggravating background. The authors analyzed the serum from 30 HIV-positive injecting drug users, 30 HIV-positive patients without drug addiction. The control group consisted of 30 healthy people, negative in screening for HIV-infection, and the comparison group consisted of 23 patients with drug dependence. The authors used xMap method on Bioplex 3D with set Cancer Biomarcers panel: sHER/2, sEGFR, sIL-6Ra, FGF, sVEGFR-2, PECAM1, PDGF AB/BB, G-SCF, sTIE2, SCF, sVEGFR -1, osteopantin. The authors of the article revealed the increased levels of sHER/2, sEGRf, sIL-6RA, sVEGfr2, PECAM1, sTIE2 in all HIV-infected patients. SCF and FGF markers were increased only in injecting drug users (HIV+/HIV-). The drug addicts with HIV had the increased level of inflammatory markers sIL-6RA, PECAM 1, osteopantin and the level of HER-2. Thus, the study of carcinogenesis biomarkers has its own peculiarities in HIV-positive patients, including with complications of drug addiction.

онкомаркерыракВИЧпотребители инъекционных форм наркотиковонкомаркерлерқатерлі ісікВИЧесірткінің инъекциялық формаларын тұтынушыларcancer biomarkerscancerHIVdrug addictionReferencesAppert-CoMin A. Role of ErbB Receptors in Cancer Cell Migration and Invasion /A. Appert-Collin, P. Hubert, G. Cremel, A. //Front Pharmacol. - 2015. - V. 6. - P. 283-291.Appert-CoMin A. Role of ErbB Receptors in Cancer Cell Migration and Invasion /A. Appert-Collin, P. Hubert, G. Cremel, A. //Front Pharmacol. - 2015. - V. 6. - P. 283-291.Calza L. Changes in Serum Markers of Inflammation and Endothelial Activation in HIV-Infected Antiretroviral Naive Patients Starting A Treatment with Abacavir-Lamivudine or Tenofovir -Emtricitabine Plus Efavirenz /L. Calza, E. Magistrelli, I. Danese //Curr. HIV Res. - 2016. - V. 14(1). - P. 61-70.Calza L. Changes in Serum Markers of Inflammation and Endothelial Activation in HIV-Infected Antiretroviral Naive Patients Starting A Treatment with Abacavir-Lamivudine or Tenofovir -Emtricitabine Plus Efavirenz /L. Calza, E. Magistrelli, I. Danese //Curr. HIV Res. - 2016. - V. 14(1). - P. 61-70.Cohen J. HIV/AIDS. Cancer genes help HIV persist, complicating cure efforts //Science. -2014. - V. 14. - P. 1188.Cohen J. HIV/AIDS. Cancer genes help HIV persist, complicating cure efforts //Science. -2014. - V. 14. - P. 1188.Conroy A. L. Altered angiogenesis as a common mechanism underlying preterm birth, small for gestational age, and stillbirth in women living with HIV /A. L. Conroy, C. R. McDonald, J.L. Gamble //Am. J. Obstet. Gynecol. - 2017. - V. 217 (6). - P. 684-689.Conroy A. L. Altered angiogenesis as a common mechanism underlying preterm birth, small for gestational age, and stillbirth in women living with HIV /A. L. Conroy, C. R. McDonald, J.L. Gamble //Am. J. Obstet. Gynecol. - 2017. - V. 217 (6). - P. 684-689.Dysangco A. HIV-infection, antiretroviral therapy, and measures of endothelial function, inflammation, metabolism, and oxidative stress / A. Dysangco, Z. Liu, J. H. Stein //PLoS One. -2017. - V. 12. - e0183511Dysangco A. HIV-infection, antiretroviral therapy, and measures of endothelial function, inflammation, metabolism, and oxidative stress / A. Dysangco, Z. Liu, J. H. Stein //PLoS One. -2017. - V. 12. - e0183511Eugenin E. A. Shedding of PECAM-1 during HIV infection: a potential role for soluble PECAM-1 in the pathogenesis of NeuroAIDS /E. A. Eugenin, R. Gamss, C. Buckner //J. Leukoc. Biol. - 2006. - V. 79 (3). - P. 444-452.Eugenin E. A. Shedding of PECAM-1 during HIV infection: a potential role for soluble PECAM-1 in the pathogenesis of NeuroAIDS /E. A. Eugenin, R. Gamss, C. Buckner //J. Leukoc. Biol. - 2006. - V. 79 (3). - P. 444-452.Eller M. A. Biomarkers of Inflammation Correlate with Clinical Scoring Indices in HIV-Infected Kenyans /M. A. Eller, A. Letizia, C. Polyak //J. Infect. Dis. - 2018. - [Epub ahead of print].Eller M. A. Biomarkers of Inflammation Correlate with Clinical Scoring Indices in HIV-Infected Kenyans /M. A. Eller, A. Letizia, C. Polyak //J. Infect. Dis. - 2018. - [Epub ahead of print].Graham S. M. Elevation of soluble intercellular adhesion molecule-1 levels, but not angio-poietin 2, in the plasma of human immunodeficiency virus-infected African women with clinical Kaposi sarcoma /S. M. Graham, N. Rajwans, B. A. Richardson //Am. J. Trop. Med. Hyg. - 2014. - V. 91 (4). - P. 705-708.Graham S. M. Elevation of soluble intercellular adhesion molecule-1 levels, but not angio-poietin 2, in the plasma of human immunodeficiency virus-infected African women with clinical Kaposi sarcoma /S. M. Graham, N. Rajwans, B. A. Richardson //Am. J. Trop. Med. Hyg. - 2014. - V. 91 (4). - P. 705-708.Hesso N. Lung cancer incidence and survival among hiv-infected and uninfected women and men /N. Hesso, O. Martinezmaza, A. M. Levine //AIDS. - 2015. - V. 29 (10). - P. 1183-1193.Hesso N. Lung cancer incidence and survival among hiv-infected and uninfected women and men /N. Hesso, O. Martinezmaza, A. M. Levine //AIDS. - 2015. - V. 29 (10). - P. 1183-1193.Korgaonkar S. N. HIV-1 upregulates VEGF in podocytes /S. N. Korgaonkar, X. Feng // J. Am. Soc. Nephrol. - 2008. - V. 19 (5). - P. 877 -883.Korgaonkar S. N. HIV-1 upregulates VEGF in podocytes /S. N. Korgaonkar, X. Feng // J. Am. Soc. Nephrol. - 2008. - V. 19 (5). - P. 877 -883.Papila C. Clinical significance and prognostic value of serum sHER-2/neu levels in patients with solid tumors /C. Papila, H. Uzun, H. Balci //Medical Oncology. - 2009. - V. 26. - P. 151-156.Papila C. Clinical significance and prognostic value of serum sHER-2/neu levels in patients with solid tumors /C. Papila, H. Uzun, H. Balci //Medical Oncology. - 2009. - V. 26. - P. 151-156.Sigel K. Lung Malignancies in HIV Infection/ K. Sigel, R. Pitts //Semin. Respir. Crit. Care. Med. - 2016. - V. 37 (2). - P. 267-276.Sigel K. Lung Malignancies in HIV Infection/ K. Sigel, R. Pitts //Semin. Respir. Crit. Care. Med. - 2016. - V. 37 (2). - P. 267-276.Thakoordeen S. Serum levels of platelet endothelial cell adhesion molecule-1 (PECAM-1) and soluble vascular endothelial growth factor receptor (sVEGFR)-1 and -2 in HIV-associated preeclampsia /S. Thakoordeen, J. Moodley, T. Naicker //Hypertens Pregnancy. - 2017. - V. 36(2). - P. 168-174.Thakoordeen S. Serum levels of platelet endothelial cell adhesion molecule-1 (PECAM-1) and soluble vascular endothelial growth factor receptor (sVEGFR)-1 and -2 in HIV-associated preeclampsia /S. Thakoordeen, J. Moodley, T. Naicker //Hypertens Pregnancy. - 2017. - V. 36(2). - P. 168-174.

The authors declare that there are no conflicts of interest present.