medecolМедицина и экологияMedicine and ecology2305-60452305-6053Карагандинский медицинский университетmedecol-55Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWSБИОМАРКЕРЫ В ДИАГНОСТИКЕ КОЛОРЕКТАЛЬНОГО РАКАBIOMARKER IN DIAGNOSIS OF COLORECTAL CANCERАхмалтдиноваЛ. Л.AkhmaitdinovaL. L.noemail@neicon.ruАвдиенкоО. В.AvdiyenkoO. V.noemail@neicon.ruСиротаВ. Б.SirotaV. B.noemail@neicon.ruЖумалиеваВ. А.ZhumaiiyevaV. A.noemail@neicon.ruТурмухамбетоваА. А.TurmukhambetovaA. A.noemail@neicon.ruКарагандинский государственный медицинский университетКазахстанKaraganda state medical universityKazakhstan201807092021031116Copyright © Ахмалтдинова Л.Л., Авдиенко О.В., Сирота В.Б., Жумалиева В.А., Турмухамбетова А.А., 20212021Ахмалтдинова Л.Л., Авдиенко О.В., Сирота В.Б., Жумалиева В.А., Турмухамбетова А.А.Akhmaitdinova L.L., Avdiyenko O.V., Sirota V.B., Zhumaiiyeva V.A., Turmukhambetova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medecol.qmu.kz/jour/article/view/55

В Казахстане в последние годы отмечается рост заболеваемости колоректальным раком, что отражает глобальные тенденции. Важным моментом в профилактике этой патологии является скрининг и неинвазивная ранняя диагностика, своевременное определение прогноза, стадии и подходов к терапии. Представленный обзор посвящен методам диагностики колоректального рака. Программы национального скрининга основаны на доказательствах эффективности методов и внедрены в практику здравоохранения. В обзоре литературы приведены современные данные применения сывороточных биомаркеров в качестве скрининга, диагностики, прогноза. Отражены как диагностическая ценность классических сывороточных маркеров (РЭА, СА 19-9, СА 72-4), так и новых (циклооксигеназы, к53, Fas, TIMP-1, ММР-9, IL8, IL6, TGFB1, TIMP2 и IGF2). Изучены вопросы сложности подбора сывороточных маркеров и ограничения их применения.

The incidence of colorectal cancers is constantly growing and reflects global trends. Prophylactic of pathology includes screening and non-invasive episodes of diagnosis, prognosis of neoplastic disease, stages and pathologies. A review has been provided of the diagnosis of colorectal cancer. The programs of national screening are based on techniques and evidence-based healthcare practices. The review shows recent information on serum biomarkers in screening, diagnosis, prognosis, diagnostic value of classical serum markers (CEA, CA 19-9, CA 72-4), and novel they (cyclooxygenase, k53, Fas, TIMP-1, MDR-9, IL8, IL6, TGFB1, TIMP2 and IGF2). The review told about the problems of the selection of serum markers and the limitations of their use.

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The authors declare that there are no conflicts of interest present.