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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medecol</journal-id><journal-title-group><journal-title xml:lang="ru">Медицина и экология</journal-title><trans-title-group xml:lang="en"><trans-title>Medicine and ecology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-6045</issn><issn pub-type="epub">2305-6053</issn><publisher><publisher-name>Карагандинский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medecol-41</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТЕОРЕТИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>THEORETICAL AND EXPERIMENTAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>ОЦЕНКА ОТХАРКИВАЮЩЕГО ДЕЙСТВИЯ СУММАРНЫХ ЭКСТРАКТОВ ТИМЬЯНА ПОЛЗУЧЕГО, ПРОИЗРАСТАЮЩЕГО НА ТЕРРИТОРИИ КАЗАХСТАНА</article-title><trans-title-group xml:lang="en"><trans-title>EVALUATION OF EXPECTORANT ACTIVITY OF THE TOTAL EXTRACTS OF THYMUS SERPYLLUM L.S.L., GROWING ON THE TERRITORY OF KAZAKHSTAN</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Оразбаева</surname><given-names>П. З.</given-names></name><name name-style="western" xml:lang="en"><surname>Orazbayeva</surname><given-names>P. Z.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шакаримова</surname><given-names>К. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Shakarimova</surname><given-names>K. K.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахметова</surname><given-names>С. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhmetova</surname><given-names>S. B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Медешова</surname><given-names>А. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Medeshova</surname><given-names>A. T.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лосева</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Loseva</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивасенко</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivasenko</surname><given-names>S. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Карагандинский государственный медицинский университет<country>Казахстан</country></aff><aff xml:lang="en">Karaganda state medical university<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>07</day><month>09</month><year>2021</year></pub-date><volume>0</volume><issue>2</issue><fpage>77</fpage><lpage>80</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Оразбаева П.З., Шакаримова К.К., Ахметова С.Б., Медешова А.Т., Лосева И.В., Ивасенко С.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Оразбаева П.З., Шакаримова К.К., Ахметова С.Б., Медешова А.Т., Лосева И.В., Ивасенко С.А.</copyright-holder><copyright-holder xml:lang="en">Orazbayeva P.Z., Shakarimova K.K., Akhmetova S.B., Medeshova A.T., Loseva I.V., Ivasenko S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medecol.qmu.kz/jour/article/view/41">https://medecol.qmu.kz/jour/article/view/41</self-uri><abstract><p>Цель: изучение отхаркивающей активности сухих суммарных экстрактов двух хемотипов тимьяна ползучего ( Thymusserpyllum L.s.l.), собранных на территории Казахстана. Материалы и методы: для оценки отхаркивающего действия сухих суммарных экстрактов двух хемотипов тимьяна ползучего, собранных в популяциях Карагандинской области в Корнеевских лесах и лесах Каркаралинска, использовали модель изучения моторной функции мерцательного эпителия пищевода лягушки по методике В. В. Гацура. Экспериментальная работа выполнена на осенних лягушках Rana Temporarea. Результаты и обсуждение: экспериментально установлено, что сухой суммарный экстракт тимьяна ползучего, произрастающего в лесах Каркаралинска, обладает отхаркивающей активностью, сопоставимой с препаратом сравнения - сиропом Бронхикум С, а сухой суммарный экстракт тимьяна ползучего, собранного в Корнеевских лесах, обладает менее выраженным отхаркивающим действием. Выводы: сухой суммарный экстракт тимьяна ползучего, произрастающего в лесах Каркаралинска, является перспективной субстанцией для разработки отечественного лекарственного средства отхаркивающего действия.</p></abstract><trans-abstract xml:lang="en"><p>Im: to study the expectorant activity of dry total extracts of two chemotypes of thyme creeping ( Thymus serpyllum Ls.l.) collected in the territory of Kazakhstan. Materials and methods: to evaluate the expectorant effect of dry total extracts of two chemotypes of thyme creeping collected in the populations of the Karaganda region in the Korneevsky forests and forests of Karkaralinsk, was used studying the motor function of the ciliary epithelium of model of the frog's esophagus by the method Gatsura. Experimental work was performed on the autumn frogs Rana Temporarea. Results and discussioi: it has been experimentally established that the dry total extract of creeping thyme growing in the forests of Karkaralinsk has expectorant activity comparable to the reference preparation - Bronchicum C syrup, and the dry total extract of creeping thyme collected in the Korneevsky forests has a less pronounced expectorant effect. Conclusion: dry total extract of creeping thyme, which grows in the forests of Karkaralinsk, is a promising substance for the development of a domestic medicine for expectorant action.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сухой суммарный экстракт</kwd><kwd>отхаркивающая активность</kwd><kwd>құрғақ сумарлы экстракті</kwd><kwd>қақырық түсіретін белсенділігі</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Thymus serpyllum L.s.l</kwd><kwd>dry total extract</kwd><kwd>expectorant activity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Государственная фармакопея СССР. - М., 1990. - Т. XI, вып. 2. - С. 60.</mixed-citation><mixed-citation xml:lang="en">Государственная фармакопея СССР. - М., 1990. - Т. 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