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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medecol</journal-id><journal-title-group><journal-title xml:lang="ru">Медицина и экология</journal-title><trans-title-group xml:lang="en"><trans-title>Medicine and ecology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-6045</issn><issn pub-type="epub">2305-6053</issn><publisher><publisher-name>Карагандинский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medecol-353</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Анализ связи между витамином D и ХБП</article-title><trans-title-group xml:lang="en"><trans-title>Analysis of the relationship between vitamin D and CKD</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дюсенова</surname><given-names>С. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Dyussenova</surname><given-names>S. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра педиатрии и неонатологии</p><p>Караганда</p></bio><bio xml:lang="en"><p>Sandugash Bolatovna Dyussenova – doctor of medical sciences, professor of Pediatrics and NeonatologyDepartment, tel.:+77014720912</p><p>Karaganda</p></bio><email xlink:type="simple">dyusenova@mail.kz</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исаев</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Isayev</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра педиатрии и неонатологии</p><p>Караганда</p></bio><bio xml:lang="en"><p>Department of Pediatrics and Neonatology</p><p>Karaganda</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Букаев</surname><given-names>Э. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Bukayev</surname><given-names>E. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра педиатрии и неонатологии</p><p>Караганда</p></bio><bio xml:lang="en"><p>Department of Pediatrics and Neonatology</p><p>Karaganda</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Карагандинский медицинский университет<country>Казахстан</country></aff><aff xml:lang="en">Karaganda Medical University<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>02</day><month>06</month><year>2023</year></pub-date><volume>0</volume><issue>2</issue><fpage>39</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дюсенова С.Б., Исаев В.А., Букаев Э.Т., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Дюсенова С.Б., Исаев В.А., Букаев Э.Т.</copyright-holder><copyright-holder xml:lang="en">Dyussenova S.B., Isayev V.A., Bukayev E.T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medecol.qmu.kz/jour/article/view/353">https://medecol.qmu.kz/jour/article/view/353</self-uri><abstract><p>Статья указывает на то, что витамин D и его метаболиты влияют на функцию проксимальных канальцев. Цель – обосновать роль витамина D в прогрессировании и прогнозировании ХБП у детей. Результаты данного исследования демонстрируют, что у детей с ХБП распространен дефицит витамина D. Определение уровня витамина D у детей с ХБП является важным для своевременной коррекции и предотвращения дальнейшего прогрессирования ХБП. Вовремя начатая заместительная терапия улучшит качество жизни ребенка с ХБП и предупредит развитие осложнений.</p></abstract><trans-abstract xml:lang="en"><p>Severe vitamin D deficiency (decreased concentration of 25 (OH) D in serum) in infants and children can cause signs of Fanconi syndrome, including phosphaturia, glucosuria, aminoaciduria and renal tubule acidosis. This indicates that vitamin D and its metabolites affect the function of the proximal tubules. Objective: to substantiate the role of vitamin D in the progression and prognosis of CKD in children. Results of this study demonstrate that vitamin D deficiency is common in children with CKD. Determination of vitamin D levels in children with CKD is important for timely correction and prevention of further progression of CKD. Timely replacement therapy will improve the quality of life of a child with CKD and prevent the development of complications.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>хроническая болезнь почек</kwd><kwd>дефицит витамина Д</kwd><kwd>прогнозирование</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>chronic kidney disease</kwd><kwd>vitamin D deficiency</kwd><kwd>prognosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Altemose KE, Kumar J, Portale AA, et al. Vitamin D insufficiency, hemoglobin, and anemia in children with chronic kidney disease. 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