Tooth enamel is the hardest tissue in the human body. Mature enamel is an inanimate tissue and can not regenerate after a significant loss of minerals, which often arises from caries or erosion. Despite efforts to remineralize enamel, the prevention and treatment of initial carious lesions and submicrometric erosion are still major clinical problems. Currently, these lesions are treated by removing the altered tissue and filling the resulting cavity with restorative materials. As a potential alternative to traditional treatment, the biomimetic reconstruction of tooth enamel can regenerate the organized enamel-imitating apatite crystals with reliable binding to the surface of natural enamel. In recent studies, the Kazakhstan researcher BA Aituov developed a drug for non-invasive treatment of focal demineralization of tooth enamel, a biocompatible synthetic analog of the human amelogenin protein, which plays a key role in the formation of enamel in odontogenesis. However, this technique has no experimental studies on animals and has insufficient clinical data and morphological justification for the processes of enamel regeneration. Therefore, the solution of this urgent problem will allow us to study in more detail the processes occurring in the enamel of the teeth upon exposure to this preparation.