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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medecol</journal-id><journal-title-group><journal-title xml:lang="ru">Медицина и экология</journal-title><trans-title-group xml:lang="en"><trans-title>Medicine and ecology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-6045</issn><issn pub-type="epub">2305-6053</issn><publisher><publisher-name>Карагандинский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medecol-226</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEWS</subject></subj-group></article-categories><title-group><article-title>СПЕКТР БАКТЕРИАЛЬНЫХ ВОЗБУДИТЕЛЕЙ У ПАЦИЕНТОВ ПРИ СТЕНТИРОВАНИИ ВЕРХНИХ МОЧЕВЫВОДЯЩИХ ПУТЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>SPECTRUM OF BACTERIAL PATHOGENS IN PATIENTS WITH UPPER URINARY TRACT STENTING</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симохина</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Simokhina</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калиева</surname><given-names>Ш. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaliyeva</surname><given-names>Sh. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корниенко</surname><given-names>Ю. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kornienko</surname><given-names>Y. Y.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Медицинский университет Караганды<country>Казахстан</country></aff><aff xml:lang="en">Karaganda medical university<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>07</day><month>09</month><year>2021</year></pub-date><volume>0</volume><issue>4</issue><fpage>19</fpage><lpage>24</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Симохина Н.А., Калиева Ш.С., Корниенко Ю.Ю., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Симохина Н.А., Калиева Ш.С., Корниенко Ю.Ю.</copyright-holder><copyright-holder xml:lang="en">Simokhina N.A., Kaliyeva S.S., Kornienko Y.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medecol.qmu.kz/jour/article/view/226">https://medecol.qmu.kz/jour/article/view/226</self-uri><abstract><p>В представленном литературном обзоре проведена оценка спектра возбудителей, выделенных у пациентов до и после стентирования верхних мочевыводящих путей, на основании литературных данных зарубежных источников. Выявлено, что наиболее частыми микроорганизмами, выделенными из образцов мочи и стентов, являются Е. coli, P. mirabilis, P. aeruginosa, S. epidermidis, Е. faecium. Многие из данных микроорганизмов имеют резистентность к антибактериальным препаратам, что является актуальной проблемой, так как приводит к увеличению продолжительности госпитализации, росту смертности и повышению медицинских расходов. Несмотря на то, что на данный момент имеются зарубежные работы, подтверждающие эффективность антибактериальной профилактики и терапии при стентировании мочевыводящих путей, до сих пор отсутствуют локальные данные о спектре микроорганизмов и их чувствительности к антибактериальным препаратам, что и определяет актуальность будущих исследований.</p></abstract><trans-abstract xml:lang="en"><p>In this review, the spectrum of pathogens isolated from patients before and after upper urinary tract stenting was evaluated based on literature data from foreign sources. Analysis of the literature data revealed that the most frequent microorganisms isolated from urine samples and stents are E. coii, P. mirabiiis, P. aeruginosa, S. epidermidis and E. faecium. Many of these microorganisms are resistant to antibacterial drugs, which is an urgent problem, as it leads to an increase in the length of hospitalization, increased mortality and increased medical costs. Despite the fact that at the moment there are foreign works confirming the effectiveness of antibacterial prevention and therapy for urinary tract stenting, there is still no local data on the spectrum of microorganisms and their sensitivity to antibacterial drugs, which determines the relevance of future research.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>стентирование</kwd><kwd>возбудитель</kwd><kwd>мочевыводящие пути</kwd><kwd>колонизация</kwd><kwd>антибиотикорезистентность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>stenting</kwd><kwd>pathogen</kwd><kwd>urinary tract</kwd><kwd>colonization</kwd><kwd>antibiotic resistance</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Дорончук Д. Н. Выбор метода дренирования верхних мочевых путей при мочекаменной болезни /Д. Н. Дорончук, М. Ф. Трапезникова, В. В. Дутов //Урология. - 2010. -№3. - С. 7-10.</mixed-citation><mixed-citation xml:lang="en">Дорончук Д. Н. Выбор метода дренирования верхних мочевых путей при мочекаменной болезни /Д. Н. Дорончук, М. Ф. Трапезникова, В. В. Дутов //Урология. - 2010. -№3. - С. 7-10.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Жантелиева Л. А. Дренирование верхних мочевых путей у детей с пузырномочеточниковым рефлюксом //Вестн. хирургии Казахстана. - 2009. - №3. - С. 37-38.</mixed-citation><mixed-citation xml:lang="en">Жантелиева Л. А. Дренирование верхних мочевых путей у детей с пузырномочеточниковым рефлюксом //Вестн. хирургии Казахстана. - 2009. - №3. - С. 37-38.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Кусымжанов С. М. Реконструктивнопластические операции с использованием метода внутреннего дренирования при гидронефрозе /С. М. Кусымжанов, К. Н. Абдильманов, Г. А. Еремьянц //Қазақстанның урология және нефрологиясы. - 2012. - №3 (4). - С. 8-14.</mixed-citation><mixed-citation xml:lang="en">Кусымжанов С. М. Реконструктивнопластические операции с использованием метода внутреннего дренирования при гидронефрозе /С. М. Кусымжанов, К. Н. Абдильманов, Г. А. Еремьянц //Қазақстанның урология және нефрологиясы. - 2012. - №3 (4). - С. 8-14.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Междисциплинарные проблемы в урологии: Рук. для врачей под ред. П. В. Глыбочко, Ю. Г. Аляева. - М.: Медфорум, 2015. - 580 с.</mixed-citation><mixed-citation xml:lang="en">Междисциплинарные проблемы в урологии: Рук. для врачей под ред. П. В. Глыбочко, Ю. Г. Аляева. - М.: Медфорум, 2015. - 580 с.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Табынбаев Н. Б. Малоинвазивные и инвазивные способы коррекции постлучевых стриктур мочеточников /Н. Б. Табынбаев, А. К. Мукажанов, А. К. Дигай //Междунар. журн. прикладных и фундаментальных исследований. - 2016. - №12. - С. 280-285.</mixed-citation><mixed-citation xml:lang="en">Табынбаев Н. Б. Малоинвазивные и инвазивные способы коррекции постлучевых стриктур мочеточников /Н. Б. Табынбаев, А. К. Мукажанов, А. К. Дигай //Междунар. журн. прикладных и фундаментальных исследований. - 2016. - №12. - С. 280-285.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Чепуров А. К. Роль инфицирования верхних мочевых путей у больных с длительным дренированием мочеточниковыми стентами /А. К. Чепуров, С. С. Зенков, И. Э. Мамаев//https://www.u roweb.ru/article/db-article-3060.html</mixed-citation><mixed-citation xml:lang="en">Чепуров А. К. Роль инфицирования верхних мочевых путей у больных с длительным дренированием мочеточниковыми стентами /А. К. Чепуров, С. С. Зенков, И. Э. Мамаев//https://www.u roweb.ru/article/db-article-3060.html</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Akay A. F. Risk factors for lower urinary tract infection and bacterial stent colonization in patients with a double J ureteral stent /A. F. Akay, U. Aflay et al. //International urology and nephrology. - 2007. - V. 39. - P. 95-98.</mixed-citation><mixed-citation xml:lang="en">Akay A. F. Risk factors for lower urinary tract infection and bacterial stent colonization in patients with a double J ureteral stent /A. F. Akay, U. Aflay et al. //International urology and nephrology. - 2007. - V. 39. - P. 95-98.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Aydin H. R. Incidence of bacterial colonisation after indwelling of double-J ureteral stent /H. R. Aydin, L. Irkilata, M. Aydin, //Archivio Italiano Urologia e Andrologia. - 2016. - V. 87 (4). - P. 291-294.</mixed-citation><mixed-citation xml:lang="en">Aydin H. R. Incidence of bacterial colonisation after indwelling of double-J ureteral stent /H. R. Aydin, L. Irkilata, M. Aydin, //Archivio Italiano Urologia e Andrologia. - 2016. - V. 87 (4). - P. 291-294.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Chatterjee S. Biofilms on indwelling urologic devices: microbes and antimicrobial management prospect /S. Chatterjee, P. Maiti, R. Dey //Annals of Medical Health Sciences Research. - 2014. - V. 4 (1). - P. 100-104.</mixed-citation><mixed-citation xml:lang="en">Chatterjee S. Biofilms on indwelling urologic devices: microbes and antimicrobial management prospect /S. Chatterjee, P. Maiti, R. Dey //Annals of Medical Health Sciences Research. - 2014. - V. 4 (1). - P. 100-104.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Chung S. Y. 15-year experience with the management of extrinsic ureteral obstruction with indwelling ureteral stents /S. Y. Chung, R. J. Stein, D. Landsittel //Journ. of Urology. - 2004. -V. 172 (1). - P. 592-595.</mixed-citation><mixed-citation xml:lang="en">Chung S. Y. 15-year experience with the management of extrinsic ureteral obstruction with indwelling ureteral stents /S. Y. Chung, R. J. Stein, D. Landsittel //Journ. of Urology. - 2004. -V. 172 (1). - P. 592-595.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Crnich C. The promise of novel technology for the prevention of intravascular devicerelated bloodstream infection /C. Crnich, D. Maki //II. Long-term devices. Clinical infectious diseases. - 2002. - V. 34. - P. 1362-1368.</mixed-citation><mixed-citation xml:lang="en">Crnich C. The promise of novel technology for the prevention of intravascular devicerelated bloodstream infection /C. Crnich, D. Maki //II. Long-term devices. Clinical infectious diseases. - 2002. - V. 34. - P. 1362-1368.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Crnich C. Infections of implanted medical devices /C. Crnich, N. Safdar, D. Maki //Antibiotics and Chemotherapy. - London, 2001. - 434 p.</mixed-citation><mixed-citation xml:lang="en">Crnich C. Infections of implanted medical devices /C. Crnich, N. Safdar, D. Maki //Antibiotics and Chemotherapy. - London, 2001. - 434 p.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Donelli G. A multicenter study on central venous catheter-associated infections in Italy /G. Donelli, P. De Paoli, G. Fadda //Journ. of Chemotherapy. - 2001. - V. 1. - P. 251-262.</mixed-citation><mixed-citation xml:lang="en">Donelli G. A multicenter study on central venous catheter-associated infections in Italy /G. Donelli, P. De Paoli, G. Fadda //Journ. of Chemotherapy. - 2001. - V. 1. - P. 251-262.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Edwards J. R. NHSN Facilities. National Healthcare Safety Network (NHSN) Report, data summary for 2006, issued June 2007 /J. R. Edwards, K. D. Peterson, M. L Andrus //American journal of infection control. - 2007. - V. 35 (5). -P. 290-301.</mixed-citation><mixed-citation xml:lang="en">Edwards J. R. NHSN Facilities. National Healthcare Safety Network (NHSN) Report, data summary for 2006, issued June 2007 /J. R. Edwards, K. D. Peterson, M. L Andrus //American journal of infection control. - 2007. - V. 35 (5). -P. 290-301.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Francois P. Identification of plasma proteins adsorbed on hemodialysis tubing that promotes Staphylococcus aureus adhesion /P. Francois, J. Schrenzel, C. Stoerman-Chopard // Journ. of Laboratory and Clinical Medicine. -2000. - V. 135. - P. 32-42.</mixed-citation><mixed-citation xml:lang="en">Francois P. Identification of plasma proteins adsorbed on hemodialysis tubing that promotes Staphylococcus aureus adhesion /P. Francois, J. Schrenzel, C. Stoerman-Chopard // Journ. of Laboratory and Clinical Medicine. -2000. - V. 135. - P. 32-42.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Francois P. Host-bacteria interactions in foreign body infections /P. Francois, P. Vaudaux, T. J. Foster //Infection Control &amp; Hospital Epidemiology. - 1996. - V. 17. - P. 514-520.</mixed-citation><mixed-citation xml:lang="en">Francois P. Host-bacteria interactions in foreign body infections /P. Francois, P. Vaudaux, T. J. Foster //Infection Control &amp; Hospital Epidemiology. - 1996. - V. 17. - P. 514-520.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Jeong I. G. The outcome with ureteric stents for managing non-urological malignant uretric obstruction /I. G. Jeong, S. Hank, J. Y. Joung //BJU international. - 2007. - V. 100 (6). -P. 1288-1291.</mixed-citation><mixed-citation xml:lang="en">Jeong I. G. The outcome with ureteric stents for managing non-urological malignant uretric obstruction /I. G. Jeong, S. Hank, J. Y. Joung //BJU international. - 2007. - V. 100 (6). -P. 1288-1291.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kawahara T. Ureteral stent encrustation, incrustation and coloring: morbidity related to indwelling times /T. Kawahara, H. Ito, H. Terao //Journ. of Endourology. - 2012. - V. 26. -P. 178-182.</mixed-citation><mixed-citation xml:lang="en">Kawahara T. Ureteral stent encrustation, incrustation and coloring: morbidity related to indwelling times /T. Kawahara, H. Ito, H. Terao //Journ. of Endourology. - 2012. - V. 26. -P. 178-182.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Maki D. G. Engineering out the risk for infection with urinary catheters /D. G. Maki, P. A. Tambyah //Emerging infectious diseases. - 2001. -V. 7. - P. 342-347.</mixed-citation><mixed-citation xml:lang="en">Maki D. G. Engineering out the risk for infection with urinary catheters /D. G. Maki, P. A. Tambyah //Emerging infectious diseases. - 2001. -V. 7. - P. 342-347.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Mathe L. Recent insights into Candida albicans biofilm resistance mechanisms /L. Mathe, P. Van Dijck //Current genetics. - 2013. - V. 59 (4). - P. 251-264.</mixed-citation><mixed-citation xml:lang="en">Mathe L. Recent insights into Candida albicans biofilm resistance mechanisms /L. Mathe, P. Van Dijck //Current genetics. - 2013. - V. 59 (4). - P. 251-264.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Pittet D. Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality /D. Pittet, D. Tarara, R. P. Wenzel //JAMA. - 1994. -V. 271. - P. 1598-1601.</mixed-citation><mixed-citation xml:lang="en">Pittet D. Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality /D. Pittet, D. Tarara, R. P. Wenzel //JAMA. - 1994. -V. 271. - P. 1598-1601.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Rodriguez-Bano J. Selection of empiric therapy in patients with catheter-related infections //Clinical Microbiology and Infection. -2002. - V. 8. - P. 275-281.</mixed-citation><mixed-citation xml:lang="en">Rodriguez-Bano J. Selection of empiric therapy in patients with catheter-related infections //Clinical Microbiology and Infection. -2002. - V. 8. - P. 275-281.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Rosman B. M. Evaluation of a novel gel-based ureteral stent with biofilm-resistant characteristics /B. M. Rosman, J. A. Barbosa, C. P. Passerotti //International Urology and Nephrology. - 2014. - V. 46. - P. 1053-1058.</mixed-citation><mixed-citation xml:lang="en">Rosman B. M. Evaluation of a novel gel-based ureteral stent with biofilm-resistant characteristics /B. M. Rosman, J. A. Barbosa, C. P. Passerotti //International Urology and Nephrology. - 2014. - V. 46. - P. 1053-1058.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Shabeena K. S. Characteristics of bacterial colonization after indwelling double-J ureteral stents for different time duration /K. S. Shabeena, B. Rahul, A. P. Muhammed //Urology Annals. - 2018. - V. 10 (1). - P. 71-75.</mixed-citation><mixed-citation xml:lang="en">Shabeena K. S. Characteristics of bacterial colonization after indwelling double-J ureteral stents for different time duration /K. S. Shabeena, B. Rahul, A. P. Muhammed //Urology Annals. - 2018. - V. 10 (1). - P. 71-75.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Tazumi A. Uneven distribution of the lux S gene within the genus Campylobacter /A. Tazumi, М. Negoro, Y. Tomiyama //British Journ. of Biomedical Science. - 2011. - V. 68 (1). - P. 19-22.</mixed-citation><mixed-citation xml:lang="en">Tazumi A. Uneven distribution of the lux S gene within the genus Campylobacter /A. Tazumi, М. Negoro, Y. Tomiyama //British Journ. of Biomedical Science. - 2011. - V. 68 (1). - P. 19-22.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Ulker V. Bacterial Colonization of Ureteral Double-J Stents in Patients with Negative Urine Culture /V. Ulker, N. Yilmaz, N. Agus // Journ. of urological surgery. - 2019. - V. 6 (2). -P. 125-129.</mixed-citation><mixed-citation xml:lang="en">Ulker V. Bacterial Colonization of Ureteral Double-J Stents in Patients with Negative Urine Culture /V. Ulker, N. Yilmaz, N. Agus // Journ. of urological surgery. - 2019. - V. 6 (2). -P. 125-129.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Van Merode A. E. Enterococcus faecalis strains show culture heterogeneity in cell surface charge /A. E. van Merode, H.С. van der Mei, H. J. Busscher //Microbiology. - 2006. - V. 152. -P. 807-814.</mixed-citation><mixed-citation xml:lang="en">Van Merode A. E. Enterococcus faecalis strains show culture heterogeneity in cell surface charge /A. E. van Merode, H.С. van der Mei, H. J. Busscher //Microbiology. - 2006. - V. 152. -P. 807-814.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmerli W. Pathogenesis of foreign body infection. Evidence for a local granulocyte defect /W. Zimmerli, P. D. Lew, F. A. Waldvogel //Journ. of Clinical Investigation. - 1984. - V. 73. - P. 1191-1200.</mixed-citation><mixed-citation xml:lang="en">Zimmerli W. Pathogenesis of foreign body infection. Evidence for a local granulocyte defect /W. Zimmerli, P. D. Lew, F. A. Waldvogel //Journ. of Clinical Investigation. - 1984. - V. 73. - P. 1191-1200.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
