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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medecol</journal-id><journal-title-group><journal-title xml:lang="ru">Медицина и экология</journal-title><trans-title-group xml:lang="en"><trans-title>Medicine and ecology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-6045</issn><issn pub-type="epub">2305-6053</issn><publisher><publisher-name>Карагандинский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.59598/ME-2305-6053-2026-118-1-33-43</article-id><article-id custom-type="elpub" pub-id-type="custom">medecol-1309</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEWS</subject></subj-group></article-categories><title-group><article-title>Хронические диффузные заболевания печени. Регистрация и учет больных, значимость регистров</article-title><trans-title-group xml:lang="en"><trans-title>Chronic diffuse liver diseases. Patient registration and accounting, the importance of registries</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аннаоразова</surname><given-names>З. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Annaorazova</surname><given-names>Z. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зарина Ихтияркызы Аннаоразова</p><p>161200, г. Туркестан, пр. Б. Саттарханова, 29</p></bio><bio xml:lang="en"><p>Zarina Ikhtiyarkyzy Annaorazova</p><p>161200,  Turkestan с., Sattarkhanov ave., 29 B</p></bio><email xlink:type="simple">zarina.annaorazova@ayu.edu</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ошибаева</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Oshibaeva</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>161200, г. Туркестан, пр. Б. Саттарханова, 29</p></bio><bio xml:lang="en"><p>161200,  Turkestan с., Sattarkhanov ave., 29 B</p></bio><email xlink:type="simple">info@ayu.edu.kz</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нускабаева</surname><given-names>Г. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Nuskabayeva</surname><given-names>G. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>161200, г. Туркестан, пр. Б. Саттарханова, 29</p></bio><bio xml:lang="en"><p>161200,  Turkestan с., Sattarkhanov ave., 29 B</p></bio><email xlink:type="simple">info@ayu.edu.kz</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Искандирова</surname><given-names>Э. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Iskandirova</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>161200, г. Туркестан, пр. Б. Саттарханова, 29</p></bio><bio xml:lang="en"><p>161200,  Turkestan с., Sattarkhanov ave., 29 B</p></bio><email xlink:type="simple">info@ayu.edu.kz</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сахова</surname><given-names>Б. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Sakhova</surname><given-names>B. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>161200, г. Туркестан, пр. Б. Саттарханова, 29</p></bio><bio xml:lang="en"><p>161200,  Turkestan с., Sattarkhanov ave., 29 B</p></bio><email xlink:type="simple">info@ayu.edu.kz</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рсалиева</surname><given-names>Ж. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Rsalieva</surname><given-names>Zh. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>161200, г. Туркестан, пр. Б. Саттарханова, 29</p></bio><bio xml:lang="en"><p>161200,  Turkestan с., Sattarkhanov ave., 29 B</p></bio><email xlink:type="simple">info@ayu.edu.kz</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аязбаева</surname><given-names>Г. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Ayazbaeva</surname><given-names>G. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>161200, г. Туркестан, пр. Б. Саттарханова, 29</p></bio><bio xml:lang="en"><p>161200,  Turkestan с., Sattarkhanov ave., 29 B</p></bio><email xlink:type="simple">info@ayu.edu.kz</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кистаубаев</surname><given-names>М. У.</given-names></name><name name-style="western" xml:lang="en"><surname>Kistaubaev</surname><given-names>M. U.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Шымкент, ул. Жандосова, 52</p></bio><bio xml:lang="en"><p>160000, Shymkent с., Zhandosov str., 52</p></bio><email xlink:type="simple">shgmb17@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Международный казахско-турецкий университет им. Ходжи Ахмета Ясави<country>Казахстан</country></aff><aff xml:lang="en">Khoja Ahmet Yasawi International Kazakh-Turkish University<country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Шымкентская городская многопрофильная больница №2<country>Казахстан</country></aff><aff xml:lang="en">Shymkent Multidisciplinary Hospital №2<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>05</day><month>07</month><year>2026</year></pub-date><volume>0</volume><issue>1</issue><fpage>33</fpage><lpage>43</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Аннаоразова З.И., Ошибаева А.Е., Нускабаева Г.О., Искандирова Э.Д., Сахова Б.О., Рсалиева Ж.И., Аязбаева Г.Б., Кистаубаев М.У., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Аннаоразова З.И., Ошибаева А.Е., Нускабаева Г.О., Искандирова Э.Д., Сахова Б.О., Рсалиева Ж.И., Аязбаева Г.Б., Кистаубаев М.У.</copyright-holder><copyright-holder xml:lang="en">Annaorazova Z.I., Oshibaeva A.E., Nuskabayeva G.O., Iskandirova E.D., Sakhova B.O., Rsalieva Z.M., Ayazbaeva G.B., Kistaubaev M.U.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medecol.qmu.kz/jour/article/view/1309">https://medecol.qmu.kz/jour/article/view/1309</self-uri><abstract><sec><title>Цель</title><p>Цель. Изучить роль медицинских регистров в мониторинге, диагностике и лечении пациентов с хроническими заболеваниями печени, а также оценить международный опыт в этой области.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Был проведен обзор отечественных и зарубежных источников, включая клинические рекомендации (AASLD, EASL, KASL), эпидемиологические исследования и данные о работе крупных регистров (TARGET-LD, Global Liver Registry, DELIVER, MAFLD Registry, PBC Registry). Поиск литературы проводился за период с 2018 по 2025 год в международных научных базах данных: PUBMED/MEDLINE, Cochrane Library, ScienceDirect, а также в электронных библиотеках Wiley, Springer, Elsevier, Karger и на официальных сайтах профильных организаций (EASL, AASLD, KASL, ВОЗ).</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. Регистры обеспечивают централизованный сбор данных о пациентах с ХДЗП, способствуя стандартизации диагностики, оценке эффективности лечения, стратификации риска и формированию доказательной базы для принятия клинических решений. Международный опыт показывает большую важность таких систем для разработки национальных стратегий здравоохранения. Однако отсутствие единых стандартов и недостаточное финансирование особенно остро ощущается в странах с ограниченными ресурсами, что приводит к фрагментации данных и невозможности проведения аналогичных исследований.</p></sec><sec><title>Выводы</title><p>Выводы. Создание национальных регистров пациентов с ХБП в Казахстане и других странах СНГ позволит значительно улучшить качество медицинской помощи, обеспечить профессиональный подход и повысить эффективность диагностики и лечения на всех этапах.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Chronic diﬀuse liver diseases (CDLD), including non-alcoholic and metabolically associated fatty liver disease (MAFLD), remain the leading cause of liver failure, cirrhosis, and hepatocellular carcinoma. The increasing incidence of these diseases requires not only eﬀective clinical approaches but also systematic patient monitoring.</p></sec><sec><title>Aim</title><p>Aim. To study the role of medical registries in monitoring, diagnosing, and treating patients with chronic diﬀuse liver diseases, and to evaluate international experience in this area.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A review of domestic and international sources was conducted, including clinical guidelines (AASLD, EASL, KASL), epidemiological studies, and descriptions of the functioning of large registries (TARGET-LD, Global Liver Registry, DELIVER, MAFLD Registry, PBC Registry). A literature search was conducted for the period from 2018 to 2025 in international scientiﬁc databases: PubMed/MEDLINE, Cochrane Library, ScienceDirect, as well as in the Wiley, Springer, Elsevier, and Karger online libraries and on the oﬃcial websites of relevant organizations (EASL, AASLD, KASL, WHO).</p></sec><sec><title>Results and discussion</title><p>Results and discussion. Registers provide centralized data collection on patients with chronic kidney disease, facilitate standardized diagnostics, assess treatment eﬀectiveness, stratify risks, and generate an evidence base for clinical decisions. International experience demonstrates the signiﬁcant importance of such systems for developing national healthcare strategies. However, the lack of uniform standards and funding are particularly acute in resource-limited countries, leading to data fragmentation and the impossibility of conducting comparable studies.</p></sec><sec><title>Conclusion</title><p>Conclusion. The creation of national registries of patients with chronic diﬀuse liver disease in Kazakhstan and other CIS countries will signiﬁcantly improve the quality of medical care, ensure a multidisciplinary approach, and increase the eﬀectiveness of diagnosis and treatment at all stages.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хронические диффузные заболевания печени</kwd><kwd>хронический гепатит</kwd><kwd>метаболически ассоциированная жировая болезнь печени</kwd><kwd>цирроз</kwd><kwd>регистры заболеваний печени</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic diffuse liver disease</kwd><kwd>chronic hepatitis</kwd><kwd>MAFLD</kwd><kwd>cirrhosis</kwd><kwd>liver disease registries</kwd></kwd-group><funding-group xml:lang="en"><funding-statement>This research was funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan (Grant No. BR24992814)</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma A., Nagalli S. 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