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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medecol</journal-id><journal-title-group><journal-title xml:lang="ru">Медицина и экология</journal-title><trans-title-group xml:lang="en"><trans-title>Medicine and ecology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-6045</issn><issn pub-type="epub">2305-6053</issn><publisher><publisher-name>Карагандинский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medecol-115</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>ЗНАЧЕНИЕ ПРЕСЕПСИНА ПРИ ИНТРААБДОМИНАЛЬНОЙ ГИПЕРТЕНЗИИ</article-title><trans-title-group xml:lang="en"><trans-title>PRESEPSIN SIGNIFICANCE AT INTRAABDOMINAL HYPERTENSION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мугазов</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Mugazov</surname><given-names>M. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Матюшко</surname><given-names>Д. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Matyushko</surname><given-names>D. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исмаилов</surname><given-names>Э. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ismailov</surname><given-names>Ye. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тургунов</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Turgunov</surname><given-names>Ye. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Медицинский университет Караганды<country>Казахстан</country></aff><aff xml:lang="en">Karaganda medical university<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>07</day><month>09</month><year>2021</year></pub-date><volume>0</volume><issue>2</issue><fpage>36</fpage><lpage>40</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мугазов М.М., Матюшко Д.Н., Исмаилов Э.А., Тургунов Е.М., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Мугазов М.М., Матюшко Д.Н., Исмаилов Э.А., Тургунов Е.М.</copyright-holder><copyright-holder xml:lang="en">Mugazov M.M., Matyushko D.N., Ismailov Y.A., Turgunov Y.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medecol.qmu.kz/jour/article/view/115">https://medecol.qmu.kz/jour/article/view/115</self-uri><abstract><p>В статье представлены результаты изучения влияния интраабдоминальной гипертензии на уровень высокоспецифического биомаркера транслокации грамотрицательной микрофлоры через поврежденную кишечную стенку пресепсина у пациентов с острой хирургической патологией органов брюшной полости. Согласно результатам исследования повышение уровня интраабдоминального давления у пациентов с острой абдоминальной патологией приводит к повышению уровня пресепсина, обусловливая развитие пресептического состояния, которое заканчивается развитием синдрома системного воспалительного ответа, что значительно ухудшает тяжесть, течение и прогнозы основного заболевания у данной категории пациентов. Ранняя диагностика данного состояния, следовательно, и раннее начало терапии имеет решающее значение в выживаемости пациентов.</p></abstract><trans-abstract xml:lang="en"><p>The article presents the results of the study of the effect of intra-abdominal hypertension on the level of highly specific biomarker of gram-negative microflora translocation through the damaged intestinal wall of presepsin in patients with acute surgical pathology of the abdominal cavity. According to the study, an increase in the level of intra-abdominal pressure in patients with acute abdominal pathology leads to an increase in the level of presepsin, causing the development of a preseptic condition that ends with the development of the systemic inflammatory response syndrome, which significantly worsens the severity, course and prognosis of the underlying disease in this category of patients. Early diagnosis of this condition, therefore, early initiation of therapy is crucial in patient survival.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>интраабдоминальная гипертензия</kwd><kwd>компартмент-синдром</kwd><kwd>пресепсин</kwd><kwd>внутрибрюшное давление</kwd><kwd>ішек-қарын гипертониясы</kwd><kwd>компартия синдромы</kwd><kwd>преспсин</kwd><kwd>іштің ішкі қысымы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>intra-abdominal hypertension</kwd><kwd>compartment syndrome</kwd><kwd>presepsin</kwd><kwd>intra-abdominal pressure</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Вельков В.В. Пресепсин - новый высокоэффективным биомаркер сепсиса //Клинико-лабораторный консилиум. - 2012. - №2 (42). -C. 56-62.</mixed-citation><mixed-citation xml:lang="en">Вельков В.В. 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