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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medecol</journal-id><journal-title-group><journal-title xml:lang="ru">Медицина и экология</journal-title><trans-title-group xml:lang="en"><trans-title>Medicine and ecology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-6045</issn><issn pub-type="epub">2305-6053</issn><publisher><publisher-name>Карагандинский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.59598/ME-2305-6053-2025-116-3-66-73</article-id><article-id custom-type="elpub" pub-id-type="custom">medecol-1039</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Динамика изменения толщины эпикардиального жира у пациентов с избыточной и нормальной массой тела после аортокоронарного шунтирования</article-title><trans-title-group xml:lang="en"><trans-title>DYNAMICS OF EPICARDIAL FAT THICKNESS IN OVERWEIGHT AND NORMAL WEIGHT PATIENTS AFTER CORONARY ARTERY BYPASS GRAFTING</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сейтекова</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Seitekova</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Айжан Нурлановна Сейтекова – Кафедра семейной медицины</p><p>100008, г. Караганда, ул. Гоголя, 40</p></bio><bio xml:lang="en"><p>Aizhan Nurlanovna Seitekova – Department of Family Medicine</p><p>100008, Karaganda c., Gogolya str., 40</p></bio><email xlink:type="simple">SeytekovaA@kgmu.kz</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Молотов-Лучанский</surname><given-names>В. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Molotov-Luchanskiy</surname><given-names>V. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>100008, г. Караганда, ул. Гоголя, 40</p></bio><bio xml:lang="en"><p>100008, Karaganda c., Gogolya str., 40</p></bio><email xlink:type="simple">info@qmu.kz</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ногальский</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nogalski</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>000288716, г. Люблин, ул. Рацлавицкие, 1; </p></bio><bio xml:lang="en"><p>000288716, Lublin, Ratslawicki str., 1</p></bio><email xlink:type="simple">rzecznik.prasowy@umlub.pl</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Косыбаева</surname><given-names>М. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosybaeva</surname><given-names>M. Ye.</given-names></name></name-alternatives><bio xml:lang="ru"><p>100008, г. Караганда, ул. Гоголя, 40</p></bio><bio xml:lang="en"><p>100008, Karaganda c., Gogolya str., 40</p></bio><email xlink:type="simple">info@qmu.kz</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вистерничан</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Visternichan</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>100008, г. Караганда, ул. Гоголя, 40</p></bio><bio xml:lang="en"><p>100008, Karaganda c., Gogolya str., 40</p></bio><email xlink:type="simple">info@qmu.kz</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">НАО «Карагандинский медицинский университет»<country>Казахстан</country></aff><aff xml:lang="en">Karaganda Medical University  NC JSC<country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Люблинский медицинский университет<country>Польша</country></aff><aff xml:lang="en">Lublin Medical University<country>Poland</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>27</day><month>09</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>66</fpage><lpage>73</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сейтекова А.Н., Молотов-Лучанский В.Б., Ногальский А., Косыбаева М.Е., Вистерничан О.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Сейтекова А.Н., Молотов-Лучанский В.Б., Ногальский А., Косыбаева М.Е., Вистерничан О.А.</copyright-holder><copyright-holder xml:lang="en">Seitekova A.N., Molotov-Luchanskiy V.B., Nogalski A., Kosybaeva M.Y., Visternichan O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medecol.qmu.kz/jour/article/view/1039">https://medecol.qmu.kz/jour/article/view/1039</self-uri><abstract><sec><title>Цель</title><p>Цель. Оценка динамики толщины эпикардиального жира у пациентов с избыточной массой тела после аортокоронарного шунтирования в сравнении с динамикой данного показателя у лиц с нормальной массой тела, перенесших аортокоронарное шунтирование.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Когортное исследование охватило 91 пациента.  Пациентов разделили на 2 группы. В 1 группу были включены пациенты с избыточной массой тела после аортокоронарного шунтирования (n=48); во 2 группу – пациенты с нормальной массой тела, также перенесшие аортокоронарное шунтирование (n=43). Пациенты были обследованы в 1 сут после восстановления кровотока и затем на 1, 2 и 3 этапах реабилитации. Проведено клиническое исследование, общий осмотр с антропометрией, измерение артериального давления, определение индекса массы тела. В числе инструментальных методов исследования использовалась трансторакальная эхокардиография. Статистический анализ данных проводился с помощью программного обеспечения STATISTICА 12.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. У пациентов 1 группы на разных этапах средняя толщина эпикардиального жира в 1 сут. после реваскуляризации миокарда составила 4,14±1,63 и на 1 этапе реабилитации уменьшилась до 4,11±1,37, на 2 этапе – до 3,69±0,66, но на 3 этапе реабилитации увеличилась до 4,54±1,28.</p></sec><sec><title>Выводы</title><p>Выводы. У пациентов с избыточной массой тела, которым проводилось аортокоронарное шунтирование в послеоперационный период толщина эпикардиального жира была в 2 раза выше по сравнению с толщиной эпикардиального жира у пациентов, также перенесших аортокоронарное шунтирование, но имеющих нормальную массу тела.</p><p>У пациентов с избыточной массой тела после аортокоронарного шунтирования толщина эпикардиального жира была статистически значимо выше к 3 этапу кардиореабилитации по сравнению этим показателем у них же до начала реабилтационных мероприятий и достоверно выше по сравнению с толщиной эпикардиального жира пациентов с нормальной массой тела, перенесших аортокоронарное шунтирование.</p><p>Повышение показателя толщины эпикардиального жира в сочетании с увеличением индекса массы миокарда левого желудочка может рассматриваться как предиктор недостаточной эффективности кардиореабилитационных мероприятий и дестабилизации метаболизма липидов в эпикарде пациентов с избыточной массой тела, перенесших аортокоронарное шунтирование.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. Evaluation of the dynamics of epicardial fat thickness (EFT) in overweight patients after coronary artery bypass grafting in comparison with the dynamics of this indicator in individuals with normal body weight who underwent coronary artery bypass grafting.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The cohort study involved 91 patients. All patients were divided into 2 groups: group 1 – overweight patients after coronary artery bypass grafting (n=48) and group 2 – patients with normal body weight after coronary artery bypass grafting (n=43). The patients were examined on the first day after the blood flow was restored, then at the 1st, 2nd and 3rd stages of rehabilitation. A clinical examination, general examination with anthropometry, measurement of blood pressure and determination of body mass index were conducted. Among the instrumental research methods, transthoracic echocardiography was used. Statistical analysis of the data was carried out using the STATISTIC 12 software.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. In group 1, at different stages of rehabilitation, it was revealed that the epicardial fat thickness index on the first day after coronary artery bypass grafting was 4.14±1.63, at the first stage of rehabilitation it decreased to 4.11 ±1.37, at the second stage it decreased to 3.69±0.66 and at the third stage of rehabilitation it increased to 4.54±1.28.</p></sec><sec><title>Conclusions</title><p>Conclusions. In overweight patients who underwent coronary artery bypass grafting, in the postoperative period, the thickness of epicardial fat was 2 times higher than the thickness of epicardial fat in patients who also underwent coronary artery bypass grafting, but had a normal body weight.</p><p>In overweight patients after coronary artery bypass grafting, the thickness of epicardial fat was statistically significantly higher by the 3rd stage of cardiorehabilitation compared to this indicator in them before the start of rehabilitation measures and significantly higher compared with the thickness of epicardial fat in patients with normal body weight who underwent coronary artery bypass grafting.</p><p>An increase in epicardial fat thickness in combination with an increase in the left ventricular myocardial mass index can be considered as a predictor of insufficient effectiveness of cardiorehabilitation measures and destabilization of lipid metabolism in the epicardium of overweight patients who underwent coronary artery bypass grafting.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>аортокоронарное шунтирование</kwd><kwd>избыточная масса тела</kwd><kwd>толщина эпикардиального жира</kwd><kwd>эхокардиография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronary artery bypass grafting</kwd><kwd>overweight</kwd><kwd>epicardial fat thickness</kwd><kwd>echocardiography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bedford E. 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