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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medecol</journal-id><journal-title-group><journal-title xml:lang="ru">Медицина и экология</journal-title><trans-title-group xml:lang="en"><trans-title>Medicine and ecology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-6045</issn><issn pub-type="epub">2305-6053</issn><publisher><publisher-name>Карагандинский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.59598/ME-2305-6053-2025-116-3-55-65</article-id><article-id custom-type="elpub" pub-id-type="custom">medecol-1038</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭКОЛОГИЯ И ГИГИЕНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ECOLOGY AND HYGIENE</subject></subj-group></article-categories><title-group><article-title>Роль социально-демографических факторов в инфицировании ВПЧ</article-title><trans-title-group xml:lang="en"><trans-title>THE ROLE OF SOCIO-DEMOGRAPHIC FACTORS IN HPV INFECTION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иманкулова</surname><given-names>Б. Ж.</given-names></name><name name-style="western" xml:lang="en"><surname>Imankulova</surname><given-names>B. Zh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Балкенже Жаркемовна Иманкулова </p><p>010000, г. Астана, пр-т Туран, 32</p></bio><bio xml:lang="en"><p>Balkenzhe Zharkemovna Imankulova </p><p>010000, Astana city, Turan Ave 32</p></bio><email xlink:type="simple">imanbalken@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Камзаева</surname><given-names>Н. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Kamzayeva</surname><given-names>N. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>010000, г. Астана, пр-т Туран, 32</p></bio><bio xml:lang="en"><p>010000, Astana city, Turan Ave 32</p></bio><email xlink:type="simple">portalnncmd@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галым</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Galym</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>010000, г. Астана, пр-т Туран, 32</p></bio><bio xml:lang="en"><p>010000, Astana city, Turan Ave 32</p></bio><email xlink:type="simple">portalnncmd@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Махамбетова</surname><given-names>С. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Makhambetova</surname><given-names>S. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>010000, г. Астана, пр-т Туран, 32</p></bio><bio xml:lang="en"><p>010000, Astana city, Turan Ave 32</p></bio><email xlink:type="simple">portalnncmd@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ибраева</surname><given-names>Ж. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Ibrayeva</surname><given-names>Zh. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>010000, г. Астана, ул. Бейбітшілік, 49а</p></bio><bio xml:lang="en"><p>010000, Astana city, Beibitshilik str., 49a</p></bio><email xlink:type="simple">mail@amu.kz</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тлеубердиева</surname><given-names>Ж. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Tleuberdieva</surname><given-names>Z. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>010000, г. Астана, пр-т Туран, 32</p></bio><bio xml:lang="en"><p>010000, Astana city, Turan Ave 32</p></bio><email xlink:type="simple">portalnncmd@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Байтас</surname><given-names>Я. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Baitas</surname><given-names>Y. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>020000, г. Астана, ул. Керея и Жанибека ханов</p></bio><bio xml:lang="en"><p>20000, Astana city, Kerey and Zhanibek Khans str. 5</p></bio><email xlink:type="simple">nusom@nu.edu.kz</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Укыбасова</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Ukybassova</surname><given-names>T. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>010000, г. Астана, пр-т Туран, 32</p></bio><bio xml:lang="en"><p>010000, Astana city, Turan Ave 32</p></bio><email xlink:type="simple">portalnncmd@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Клинический и академический отдел женского здоровья, Центр матери и ребенка, Корпоративный фонд «University Medical Center»<country>Казахстан</country></aff><aff xml:lang="en">Clinical and Academic Department of Women's Health, Center for Mothers and Children, University Medical Center Corporate Fund<country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Медицинский университет Астана<country>Казахстан</country></aff><aff xml:lang="en">Astana Medical University<country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Школа медицины, Назарбаев Университет<country>Казахстан</country></aff><aff xml:lang="en">Nazarbayev University School of Medicine<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>27</day><month>09</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>55</fpage><lpage>65</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Иманкулова Б.Ж., Камзаева Н.К., Галым М.С., Махамбетова С.Б., Ибраева Ж.Н., Тлеубердиева Ж.Т., Байтас Я.Б., Укыбасова Т.М., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Иманкулова Б.Ж., Камзаева Н.К., Галым М.С., Махамбетова С.Б., Ибраева Ж.Н., Тлеубердиева Ж.Т., Байтас Я.Б., Укыбасова Т.М.</copyright-holder><copyright-holder xml:lang="en">Imankulova B.Z., Kamzayeva N.K., Galym M.S., Makhambetova S.B., Ibrayeva Z.N., Tleuberdieva Z.T., Baitas Y.B., Ukybassova T.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medecol.qmu.kz/jour/article/view/1038">https://medecol.qmu.kz/jour/article/view/1038</self-uri><abstract><sec><title>Цель</title><p>Цель. Инфекции, вызываемые высоко онкогенными типами вируса папиломы человека (ВПЧ), могут персистировать в организме человека, что увеличивает риск развития тяжелых поражений шейки матки с последующим их прогрессированием до инвазивного рака шейки матки. Целью данного исследования было изучение социально-демографических особенностей у пациенток с предраковыми заболеваниями шейки матки и анализ связи между ВПЧ-инфекциями и предраком шейки матки.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Собраны данные 402 женщин, включенных в научный проект «Национальная программа изучения ВПЧ с разработкой интегрированного подхода к эффективной диагностике и лечению предраковых состояний» на 2024 – 2026 гг. Исследование проводится в рамках программно-целевого финансирования Министерства науки и образования Республики Казахстан.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. Средний возраст женщин с положительным результатом теста на ВПЧ составил 33.08±6.62 г. Среди инфицированных ВПЧ каждая третья не состояла в браке (31,2%), показатель разводов составил 12.8%. Барьерный метод контрацепции использовали 33,83% участниц. Но несмотря на использование барьерного метода контрацепции пациентки были инфицированы ВПЧ. Наиболее распространенными типами у пациентов как с нормальной, так и с аномальной цитологией были ВПЧ-16 и ВПЧ-52. Дисплазия легкой и тяжелой степени наиболее часто отмечалась в типах ВПЧ-16, ВПЧ-33, ВПЧ-52, ВПЧ -58.</p></sec><sec><title>Выводы</title><p>Выводы. Социально-демографические факторы, такие как возраст и семейное положение, оказывают значительное влияние на риск заражения ВПЧ. Молодые женщины и незамужние женщины, женщины, занятые на работе целый день, имеют более высокий уровень инфицирования.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. Infections caused by highly oncogenic HPV types can persist in the human body, which increases the risk of developing severe cervical lesions with their subsequent progression to invasive cervical cancer. The aim of this study was to investigate the socio-demographic characteristics of patients with precancerous diseases of the cervix and analyze the relationship between HPV infections and cervical precancerous diseases.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Data on the cervix and HPV infections were collected from 402 women included in the scientific project «National Program for the Study of HPV with the Development of an Integrated Approach to Effective Diagnosis and Treatment of Precancerous Conditions» between 2024 and 2026. The study is being conducted within the framework of program-targeted funding from the Ministry of Science and Education of the Republic of Kazakhstan.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. The average age of women in our study with a positive HPV test result was 33.08±6.62 years. Among women infected with HPV, every third woman was not married – 31.2%, the divorce rate is 12.8%. The barrier method of contraception is used in 33.8% of sample population. Furthermore, among HPV-infected women the usage of barrier contraception is 1.2 times higher. HPV-16 and HPV-52 were the most common types in patients with both normal and abnormal cytology. Mild and severe dysplasia were more frequently observed in HPV types 16, 33, 52, and 58.</p></sec><sec><title>Conclusion</title><p>Conclusion. Socio-demographic factors such as age and marital status have a significant impact on the risk of HPV infection. Young women and unmarried women, women with full-day work hours have a higher level of infection.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>вирус папилломы человека</kwd><kwd>онкоцитология</kwd><kwd>социально-демографические факторы</kwd><kwd>предраковые заболевания шейки матки</kwd><kwd>репродуктивный возраст</kwd></kwd-group><kwd-group xml:lang="en"><kwd>human papillomavirus</kwd><kwd>oncocytology</kwd><kwd>socio-demographic factors</kwd><kwd>cervical precancerous diseases</kwd><kwd>reproductive age</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>This research was funded by the Scientific Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan (grant No. BR24992853, titled «National Program for the Study of HPV with the Development of an Integrated Approach to Effective Diagnosis and Treatment of Precancerous Conditions»). 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