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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medecol</journal-id><journal-title-group><journal-title xml:lang="ru">Медицина и экология</journal-title><trans-title-group xml:lang="en"><trans-title>Medicine and ecology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2305-6045</issn><issn pub-type="epub">2305-6053</issn><publisher><publisher-name>Карагандинский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.59598/ME-2305-6053-2025-116-3-15-27</article-id><article-id custom-type="elpub" pub-id-type="custom">medecol-1034</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEWS</subject></subj-group></article-categories><title-group><article-title>Возможности исскуственного интеллекта в диагностике сердечной недостаточности</article-title><trans-title-group xml:lang="en"><trans-title>POSSIBILITIES OF ARTIFICIAL INTELLIGENCE IN HEART FAILURE DIAGNOSIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бекбосынова</surname><given-names>М.</given-names></name><name name-style="western" xml:lang="en"><surname>Bekbosynova</surname><given-names>M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>010000, г. Астана, пр-т Туран, 38</p></bio><bio xml:lang="en"><p>010000, Astana с., Turan ave., 38</p></bio><email xlink:type="simple">cardiacsurgeryres@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жетебаева</surname><given-names>С.</given-names></name><name name-style="western" xml:lang="en"><surname>Jetybayeva</surname><given-names>S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>010000, г. Астана, пр-т Туран, 38</p></bio><bio xml:lang="en"><p>010000, Astana с., Turan ave., 38</p></bio><email xlink:type="simple">cardiacsurgeryres@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сайлыбаева</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sailybayeva</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>010000, г. Астана, пр-т Туран, 38</p></bio><bio xml:lang="en"><p>010000, Astana с., Turan ave., 38</p></bio><email xlink:type="simple">cardiacsurgeryres@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тауекелова</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Taukelova</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Айнур Таукелова </p><p>010000, г. Астана, пр-т Туран, 38</p></bio><bio xml:lang="en"><p>Ainur Taukelova</p><p>010000, Astana с., Turan ave., 38</p></bio><email xlink:type="simple">a.tauekelova@umc.org.kz</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алданыш</surname><given-names>Ж.</given-names></name><name name-style="western" xml:lang="en"><surname>Aldanysh</surname><given-names>Zh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>010000, г. Астана, пр-т Туран, 38</p></bio><bio xml:lang="en"><p>010000, Astana с., Turan ave., 38</p></bio><email xlink:type="simple">cardiacsurgeryres@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кушугулова</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kushugulova</surname><given-names>А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>010000, пр-т Кабанбай батыра 53</p></bio><bio xml:lang="en"><p>010000, Astana с., Turan ave., 38</p><p>010000, Astana c., Kabanbay Batyr ave., 53</p></bio><email xlink:type="simple">nla@nu.edu.kz</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Корпоративный фонд «University Medical Center»<country>Казахстан</country></aff><aff xml:lang="en">University Medical Center Corporate Fund<country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Корпоративный фонд «University Medical Center»; Лаборатория микробиома, Центр естественных наук Национальной лаборатории Астана<country>Казахстан</country></aff><aff xml:lang="en">University Medical Center Corporate Fund; Microbiome Laboratory, Center for Life Sciences of the National Laboratory Astana<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>27</day><month>09</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>15</fpage><lpage>27</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бекбосынова М., Жетебаева С., Сайлыбаева А., Тауекелова А., Алданыш Ж., Кушугулова А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Бекбосынова М., Жетебаева С., Сайлыбаева А., Тауекелова А., Алданыш Ж., Кушугулова А.</copyright-holder><copyright-holder xml:lang="en">Bekbosynova M., Jetybayeva S., Sailybayeva A., Taukelova A., Aldanysh Z., Kushugulova А.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medecol.qmu.kz/jour/article/view/1034">https://medecol.qmu.kz/jour/article/view/1034</self-uri><abstract><sec><title>Цель</title><p>Цель. Систематический обзор современных подходов к применению искусственного интеллекта в диагностике сердечной недостаточности, проанализировать используемые алгоритмы и модели, охарактеризовать источники медицинских данных (ЭКГ, эхокардиография, ЭМК, КТ/МРТ, ангиография, носимые устройства), оценить их диагностическую эффективность (точность, AUC, чувствительность/специфичность), а также определить возможности и ограничения клинической имплементации с акцентом на условия здравоохранения в Казахстане.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Систематический поиск в базах данных PubMed, Scopus, Web of Science, IEEE Xplore и Google Scholar (2015 – 2025 гг.) выявил рецензируемые англоязычные и русскоязычные исследования по применению искусственного интеллекта в диагностике сердечной недостаточности. Два независимых рецензента проводили скрининг статей, извлечение данных и оценку качества; результаты 60 отобранных исследований были синтезированы в описательной форме с количественным обобщением там, где это было уместно.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. В 60 исследованиях (2015 – 2025 гг.) применение искусственного интеллекта к данным ЭКГ, эхокардиографии, ЭМК, визуализации и носимых устройств продемонстрировало диагностическую точность на уровне 85-95% (AUC до 0,97). Алгоритмы на основе ЭКГ надежно выявляли HFrEF, ИИ-ассистированная эхокардиография улучшала сегментацию и снижала зависимость от оператора, мультимодальные модели усиливали прогнозирование ответа на терапию (включая СРТ), тогда как внедрение в Казахстане остается на начальном этапе из-за ограничений инфраструктуры и доступа к данным.</p></sec><sec><title>Выводы</title><p>Выводы. Искусственный интеллект представляет собой перспективное направление в диагностике сердечной недостаточности, способное повысить точность, своевременность и персонализацию клинических решений. Для масштабного клинического внедрения искусственного интеллекта, особенно в Казахстане,  необходимы проспективная валидация, стандартизированные протоколы, локальные репрезентативные базы данных, надежная цифровая инфраструктура и подготовка кадров.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To summarize existing approaches to the use of artificial intelligence in the diagnosis of heart failure, to characterize the algorithms and models employed, to describe the types of medical data used (ECG, echocardiography, EMR, CT/MRI, angiography, wearables), to evaluate model performance (accuracy, AUC, sensitivity/specificity), and to assess feasibility and prospects for clinical implementation – with particular attention to the situation and challenges in Kazakhstan.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Systematic searches of PubMed, Scopus, Web of Science, IEEE Xplore and Google Scholar (2015 – 2025) identified peer-reviewed English and Russian studies on AI applications for heart failure diagnosis; two reviewers independently screened articles, extracted data and assessed quality, and results from 60 eligible studies were synthesized narratively with quantitative pooling where appropriate.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. Across 60 eligible studies (2015 – 2025), AI applied to ECG, echocardiography, EMRs, imaging and wearable data demonstrated diagnostic accuracy typically between 85-95% (AUCs up to 0.97); ECGbased algorithms reliably detected HFrEF, AI-assisted echocardiography improved segmentation and reduced operator dependence, multimodal models enhanced prediction of therapy response (including CRT), while implementation in Kazakhstan remains nascent due to infrastructure and data-access limitations.</p></sec><sec><title>Conclusion</title><p>Conclusion. Artificial intelligence is a promising direction in heart-failure diagnostics that can enhance the accuracy, timeliness and personalization of clinical decisions. For large-scale clinical adoption – especially in Kazakhstan – prospective validation, standardized protocols, local representative datasets, robust digital infrastructure and workforce training are required.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>искусственный интеллект</kwd><kwd>сердечная недостаточность</kwd><kwd>диагностика</kwd><kwd>машинное обучение</kwd><kwd>ЭКГ</kwd><kwd>эхокардиография</kwd><kwd>медицинские данные</kwd><kwd>глубокое обучение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>artificial intelligence</kwd><kwd>heart failure</kwd><kwd>diagnostics</kwd><kwd>machine learning</kwd><kwd>ECG</kwd><kwd>echocardiography</kwd><kwd>medical data</kwd><kwd>deep learning</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>This study was funded by the Committee of Science of the Ministry of Science and Higher Education of the Republic of Kazakhstan (IRN BR21882152). Sponsors played no role in the design of the study, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Krittanawong C., Johnson K.W., Venkatesh V. Artificial intelligence in the diagnosis and detection of heart failure: the past, present, and future. Rev. Cardiovasc. Med. 2021; 22 (4): 1095-1113.</mixed-citation><mixed-citation xml:lang="en">Krittanawong C., Johnson K.W., Venkatesh V. Artificial intelligence in the diagnosis and detection of heart failure: the past, present, and future. Rev. Cardiovasc. Med. 2021; 22 (4): 1095-1113.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y., Khan S., Tison G.H. Artificial Intelligence in Heart Failure: Friend or Foe? Heart Fail. Rev. 2022; 27: 1-10.</mixed-citation><mixed-citation xml:lang="en">Zhang Y., Khan S., Tison G.H. Artificial Intelligence in Heart Failure: Friend or Foe? Heart Fail. Rev. 2022; 27: 1-10.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Armoundas A.A., Narayan S.M., Arnett D.K., Spector-Bagdady K., Bennett D.A., Celi L.A., Friedman P.A., Gollob M.H., Hall J.L., Kwitek A.E., Lett E., Menon B.K., Sheehan K.A., Al-Zaiti S.S.; American Heart Association Institute for Precision Cardiovascular Medicine; Council on Cardiovascular and Stroke Nursing; Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; Council on the Kidney in Cardiovascular Disease; and Stroke Council. Use of Artificial Intelligence in Improving Outcomes in Heart Disease: A Scientific Statement From the American Heart Association. Circulation. 2024; 149 (14): e1028-e1050. https://doi:10.1161/CIR.0000000000001201</mixed-citation><mixed-citation xml:lang="en">Armoundas A.A., Narayan S.M., Arnett D.K., Spector-Bagdady K., Bennett D.A., Celi L.A., Friedman P.A., Gollob M.H., Hall J.L., Kwitek A.E., Lett E., Menon B.K., Sheehan K.A., Al-Zaiti S.S.; American Heart Association Institute for Precision Cardiovascular Medicine; Council on Cardiovascular and Stroke Nursing; Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; Council on the Kidney in Cardiovascular Disease; and Stroke Council. Use of Artificial Intelligence in Improving Outcomes in Heart Disease: A Scientific Statement From the American Heart Association. Circulation. 2024; 149 (14): e1028-e1050. https://doi:10.1161/CIR.0000000000001201</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Khan M.S., Arshad M.S., Greene S.J., Van Spall H.G.C., Pandey A., Vemulapalli S., Perakslis E., Butler J. Artificial intelligence and heart failure: A state-of-the-art review. Eur. J. Heart Fail. 2023; 25 (9): 1507-1525. https://doi:10.1002/ejhf.2994</mixed-citation><mixed-citation xml:lang="en">Khan M.S., Arshad M.S., Greene S.J., Van Spall H.G.C., Pandey A., Vemulapalli S., Perakslis E., Butler J. Artificial intelligence and heart failure: A state-of-the-art review. Eur. J. Heart Fail. 2023; 25 (9): 1507-1525. https://doi:10.1002/ejhf.2994</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Medhi D., Kamidi S.R., Mamatha Sree K.P., Shaikh S., Rasheed S., Thengu Murichathil A.H., Nazir Z. Artificial Intelligence and Its Role in Diagnosing Heart Failure: A Narrative Review. Cureus. 2024; 16 (5): e59661. https://doi:10.7759/cureus.59661</mixed-citation><mixed-citation xml:lang="en">Medhi D., Kamidi S.R., Mamatha Sree K.P., Shaikh S., Rasheed S., Thengu Murichathil A.H., Nazir Z. Artificial Intelligence and Its Role in Diagnosing Heart Failure: A Narrative Review. Cureus. 2024; 16 (5): e59661. https://doi:10.7759/cureus.59661</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Dhingra L.S., Aminorroaya A., Sangha V., Pedroso A.F., Asselbergs F.W., Brant L.C.C., Barreto S.M., Ribeiro A.L.P., Krumholz H.M., Oikonomou E.K., Khera R. Heart failure risk stratification using artificial intelligence applied to electrocardiogram images: a multinational study. Eur. Heart J. 2025; 46 (11): 1044-1053. https://doi:10.1093/eurheartj/ehae914</mixed-citation><mixed-citation xml:lang="en">Dhingra L.S., Aminorroaya A., Sangha V., Pedroso A.F., Asselbergs F.W., Brant L.C.C., Barreto S.M., Ribeiro A.L.P., Krumholz H.M., Oikonomou E.K., Khera R. Heart failure risk stratification using artificial intelligence applied to electrocardiogram images: a multinational study. Eur. Heart J. 2025; 46 (11): 1044-1053. https://doi:10.1093/eurheartj/ehae914</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Attia Z.I., Friedman P.A., Noseworthy P.A. Screening for cardiac contractile dysfunction using an artificial intelligence-enabled electrocardiogram. Nat. Med. 2019; 25 (1): 70-74.</mixed-citation><mixed-citation xml:lang="en">Attia Z.I., Friedman P.A., Noseworthy P.A. Screening for cardiac contractile dysfunction using an artificial intelligence-enabled electrocardiogram. Nat. Med. 2019; 25 (1): 70-74.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang J., Gajjala S., Agrawal P. Fully automated echocardiogram interpretation in clinical practice. Circulation. 2020; 141 (10): 750-760.</mixed-citation><mixed-citation xml:lang="en">Zhang J., Gajjala S., Agrawal P. Fully automated echocardiogram interpretation in clinical practice. Circulation. 2020; 141 (10): 750-760.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Moghaddasi H., Nourian S., Rezayi S. Early heart failure detection using EHRs and machine learning: a longitudinal approach. J. Biomed. Inform. 2022; 128: 104042.</mixed-citation><mixed-citation xml:lang="en">Moghaddasi H., Nourian S., Rezayi S. Early heart failure detection using EHRs and machine learning: a longitudinal approach. J. Biomed. Inform. 2022; 128: 104042.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Esteva A., Robicquet A., Ramsundar B. A guide to deep learning in healthcare. Nat. Med. 2019; 25: 24-29.</mixed-citation><mixed-citation xml:lang="en">Esteva A., Robicquet A., Ramsundar B. A guide to deep learning in healthcare. Nat. Med. 2019; 25: 24-29.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hannun A.Y., Rajpurkar P., Haghpanahi M. Cardiologist-level arrhythmia detection with deep neural networks. Nat. Med. 2019; 25: 65-69.</mixed-citation><mixed-citation xml:lang="en">Hannun A.Y., Rajpurkar P., Haghpanahi M. Cardiologist-level arrhythmia detection with deep neural networks. Nat. Med. 2019; 25: 65-69.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Topol E.J. High-performance medicine: the convergence of human and artificial intelligence. Nat. Med. 2019; 25 (1): 44-56.</mixed-citation><mixed-citation xml:lang="en">Topol E.J. High-performance medicine: the convergence of human and artificial intelligence. Nat. Med. 2019; 25 (1): 44-56.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Krittanawong C., Zhang H., Wang Z. Machine learning in cardiovascular medicine: are we there yet? Heart. 2017; 103 (17): 1225-1234.</mixed-citation><mixed-citation xml:lang="en">Krittanawong C., Zhang H., Wang Z. Machine learning in cardiovascular medicine: are we there yet? Heart. 2017; 103 (17): 1225-1234.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson K.W., Torres Soto J., Glicksberg B.S. Artificial intelligence in cardiology. J. Am. Coll. Cardiol. 2018; 71 (23): 2668-2679.</mixed-citation><mixed-citation xml:lang="en">Johnson K.W., Torres Soto J., Glicksberg B.S. Artificial intelligence in cardiology. J. Am. Coll. Cardiol. 2018; 71 (23): 2668-2679.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Yancy C.W., Jessup M., Bozkurt B. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure. J. Am. Coll. Cardiol. 2017; 70 (6): 776-803.</mixed-citation><mixed-citation xml:lang="en">Yancy C.W., Jessup M., Bozkurt B. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure. J. Am. Coll. Cardiol. 2017; 70 (6): 776-803.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. Ethics and governance of artificial intelligence for health. Geneva: WHO; 2021: 124.</mixed-citation><mixed-citation xml:lang="en">World Health Organization. Ethics and governance of artificial intelligence for health. Geneva: WHO; 2021: 124.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ministry of Health of the Republic of Kazakhstan. National project «Healthy Nation» for 2021 – 2025. Astana: Ministry of Health RK; 2023.</mixed-citation><mixed-citation xml:lang="en">Ministry of Health of the Republic of Kazakhstan. National project «Healthy Nation» for 2021 – 2025. Astana: Ministry of Health RK; 2023.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">UNDP Kazakhstan. Digitalization of Healthcare in Kazakhstan: Opportunities and Risks. Astana: UNDP; 2021.</mixed-citation><mixed-citation xml:lang="en">UNDP Kazakhstan. Digitalization of Healthcare in Kazakhstan: Opportunities and Risks. Astana: UNDP; 2021.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Beisekeeva A.K. Prospects for the introduction of digital technologies in cardiology practice in Kazakhstan. Medical Journal of Kazakhstan. 2022; 4: 23-29.</mixed-citation><mixed-citation xml:lang="en">Beisekeeva A.K. Prospects for the introduction of digital technologies in cardiology practice in Kazakhstan. Medical Journal of Kazakhstan. 2022; 4: 23-29.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kairgaliyev R.Sh. Possibilities of using artificial intelligence in cardiology: analysis of international experience and potential for Kazakhstan. Cardiology and Cardiovascular Surgery. 2023; 2: 11-17.</mixed-citation><mixed-citation xml:lang="en">Kairgaliyev R.Sh. Possibilities of using artificial intelligence in cardiology: analysis of international experience and potential for Kazakhstan. Cardiology and Cardiovascular Surgery. 2023; 2: 11-17.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Yoon M., Park J.J., Hur T., Hua C.H., Hussain M., Lee S., Choi D.J. Application and Potential of Artificial Intelligence in Heart Failure: Past, Present, and Future. Int. J. Heart. Fail. 2023; 6 (1): 11-19. https://doi:10.36628/ijhf.2023.0050</mixed-citation><mixed-citation xml:lang="en">Yoon M., Park J.J., Hur T., Hua C.H., Hussain M., Lee S., Choi D.J. Application and Potential of Artificial Intelligence in Heart Failure: Past, Present, and Future. Int. J. Heart. Fail. 2023; 6 (1): 11-19. https://doi:10.36628/ijhf.2023.0050</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Sokolov S.F., Popov M.A. Artificial Intelligence Applications in Cardiology: An Overview. Russ. J. Cardiol. 2023; 28 (7): 5673.</mixed-citation><mixed-citation xml:lang="en">Sokolov S.F., Popov M.A. Artificial Intelligence Applications in Cardiology: An Overview. Russ. J. Cardiol. 2023; 28 (7): 5673.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Xie Y., Zhang L., Sun W., Zhu Y., Zhang Z., Chen L., Xie M., Zhang L. Artificial Intelligence in Diagnosis of Heart Failure. J. Am. Heart. Assoc. 2025; 14 (8): e039511. https://doi:10.1161/JAHA.124.039511</mixed-citation><mixed-citation xml:lang="en">Xie Y., Zhang L., Sun W., Zhu Y., Zhang Z., Chen L., Xie M., Zhang L. Artificial Intelligence in Diagnosis of Heart Failure. J. Am. Heart. Assoc. 2025; 14 (8): e039511. https://doi:10.1161/JAHA.124.039511</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Petmezas G., Papageorgiou V.E., Vassilikos V., Pagourelias E., Tsaklidis G., Katsaggelos A.K., Maglaveras N. Recent advancements and applications of deep learning in heart failure: Α systematic review. Comput. Biol. Med. 2024; 176: 108557. https://doi:10.1016/j.compbiomed.2024.108557</mixed-citation><mixed-citation xml:lang="en">Petmezas G., Papageorgiou V.E., Vassilikos V., Pagourelias E., Tsaklidis G., Katsaggelos A.K., Maglaveras N. Recent advancements and applications of deep learning in heart failure: Α systematic review. Comput. Biol. Med. 2024; 176: 108557. https://doi:10.1016/j.compbiomed.2024.108557</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Yao X., Rushlow D.R., Inselman J.W. Electrocardiogram-based artificial intelligence for the diagnosis of heart failure: a systematic review and metaanalysis. J. Geriatr. Cardiol. 2022; 19: 1-10.</mixed-citation><mixed-citation xml:lang="en">Yao X., Rushlow D.R., Inselman J.W. Electrocardiogram-based artificial intelligence for the diagnosis of heart failure: a systematic review and metaanalysis. J. Geriatr. Cardiol. 2022; 19: 1-10.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Frizzell J.D., Liang L., Schulte P.J. Evaluation of machine learning methods for prediction of heart failure mortality and readmission: meta-analysis. BMC Cardiovasc Disord. 2025; 25: 1-12.</mixed-citation><mixed-citation xml:lang="en">Frizzell J.D., Liang L., Schulte P.J. Evaluation of machine learning methods for prediction of heart failure mortality and readmission: meta-analysis. BMC Cardiovasc Disord. 2025; 25: 1-12.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Angraal S., Mortazavi B.J., Gupta A. Heart Failure Diagnosis, Readmission, and Mortality Prediction Using Machine Learning and Artificial Intelligence Models. Curr. Epidemiol. Rep. 2020; 7: 1-9.</mixed-citation><mixed-citation xml:lang="en">Angraal S., Mortazavi B.J., Gupta A. Heart Failure Diagnosis, Readmission, and Mortality Prediction Using Machine Learning and Artificial Intelligence Models. Curr. Epidemiol. Rep. 2020; 7: 1-9.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Siontis K.C., Liu K., Bos J.M. AI-Assisted ECG. J. Am. Heart. Assoc. 2024; 13: 1-8.</mixed-citation><mixed-citation xml:lang="en">Siontis K.C., Liu K., Bos J.M. AI-Assisted ECG. J. Am. Heart. Assoc. 2024; 13: 1-8.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Bernard O., Lalande A., Zotti C. Deep Learning Techniques for Automatic MRI Cardiac Multi-Structures Segmentation and Diagnosis: Is the Problem Solved? IEEE Trans. Med. Imaging. 2018; 37 (11): 2514-2525. https://doi:10.1109/TMI.2018.2837502</mixed-citation><mixed-citation xml:lang="en">Bernard O., Lalande A., Zotti C. Deep Learning Techniques for Automatic MRI Cardiac Multi-Structures Segmentation and Diagnosis: Is the Problem Solved? IEEE Trans. Med. Imaging. 2018; 37 (11): 2514-2525. https://doi:10.1109/TMI.2018.2837502</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Moreno-Sánchez P.A. Improvement of a prediction model for heart failure survival through explainable artificial intelligence. Front. Cardiovasc. Med. 2023; 10: 1219586. https://doi:10.3389/fcvm.2023.1219586</mixed-citation><mixed-citation xml:lang="en">Moreno-Sánchez P.A. Improvement of a prediction model for heart failure survival through explainable artificial intelligence. Front. Cardiovasc. Med. 2023; 10: 1219586. https://doi:10.3389/fcvm.2023.1219586</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Ali L., Rahman A., Khan A. Survival Prediction of Heart Failure Patients using Stacked Ensemble Machine Learning Algorithm. arXiv; 2021: preprint.</mixed-citation><mixed-citation xml:lang="en">Ali L., Rahman A., Khan A. Survival Prediction of Heart Failure Patients using Stacked Ensemble Machine Learning Algorithm. arXiv; 2021: preprint.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kwon J M, Lee Y, Lee Y, et al. An explainable Transformer-based deep learning model for the prediction of incident heart failure. arXiv; 2021: preprint.</mixed-citation><mixed-citation xml:lang="en">Kwon J M, Lee Y, Lee Y, et al. An explainable Transformer-based deep learning model for the prediction of incident heart failure. arXiv; 2021: preprint.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Tison G.H., Sanchez J.M., Ballinger B. Passive detection of atrial fibrillation using a commercial wearable device. JAMA Cardiol. 2018; 3 (5): 409-416.</mixed-citation><mixed-citation xml:lang="en">Tison G.H., Sanchez J.M., Ballinger B. Passive detection of atrial fibrillation using a commercial wearable device. JAMA Cardiol. 2018; 3 (5): 409-416.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Ribeiro A.H., Ribeiro M.H., Paixão G.M.M. Automatic diagnosis of the 12-lead ECG using a deep neural network. Nat. Commun. 2020; 11 (1760): 1-9.</mixed-citation><mixed-citation xml:lang="en">Ribeiro A.H., Ribeiro M.H., Paixão G.M.M. Automatic diagnosis of the 12-lead ECG using a deep neural network. Nat. Commun. 2020; 11 (1760): 1-9.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Avram R., Olgin J.E., Kuhar P. A digital biomarker of diabetes from smartphone-based vascular signals. Nat. Med. 2020; 26: 1576-1582.</mixed-citation><mixed-citation xml:lang="en">Avram R., Olgin J.E., Kuhar P. A digital biomarker of diabetes from smartphone-based vascular signals. Nat. Med. 2020; 26: 1576-1582.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Dey D., Slomka P.J., Leeson P. Machine learning and cardiac CT: current status and future opportunities. Curr. Cardiovasc. Imaging Rep. 2018; 11: 1-12.</mixed-citation><mixed-citation xml:lang="en">Dey D., Slomka P.J., Leeson P. Machine learning and cardiac CT: current status and future opportunities. Curr. Cardiovasc. Imaging Rep. 2018; 11: 1-12.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Howell S.J., Ranjbar H., Gholami B. Machine learning to predict response to cardiac resynchronization therapy: a systematic review. J. Cardiovasc. Electrophysiol. 2022; 33 (5): 1104-1113.</mixed-citation><mixed-citation xml:lang="en">Howell S.J., Ranjbar H., Gholami B. Machine learning to predict response to cardiac resynchronization therapy: a systematic review. J. Cardiovasc. Electrophysiol. 2022; 33 (5): 1104-1113.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Goto S., Kimura M., Katsumata Y. Artificial intelligence for predicting heart failure hospitalization. ESC Heart Fail. 2021; 8: 1065-1073.</mixed-citation><mixed-citation xml:lang="en">Goto S., Kimura M., Katsumata Y. Artificial intelligence for predicting heart failure hospitalization. ESC Heart Fail. 2021; 8: 1065-1073.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Ng K., Steinhubl S.R., deFilippi C. Predicting unplanned readmission after discharge from heart failure hospitalization. PLoS One. 2016; 11 (10): e016044.</mixed-citation><mixed-citation xml:lang="en">Ng K., Steinhubl S.R., deFilippi C. Predicting unplanned readmission after discharge from heart failure hospitalization. PLoS One. 2016; 11 (10): e016044.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Al'Aref S.J., Singh G., Bavishi C. Machine learning of clinical variables and coronary artery calcium scoring for mortality risk prediction. J. Am. Heart Assoc. 2020; 9 (18): e017494.</mixed-citation><mixed-citation xml:lang="en">Al'Aref S.J., Singh G., Bavishi C. Machine learning of clinical variables and coronary artery calcium scoring for mortality risk prediction. J. Am. Heart Assoc. 2020; 9 (18): e017494.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Weng S.F., Reps J., Kai J. Can machine-learning improve cardiovascular risk prediction using routine clinical data? PLoS One. 2017; 12 (4): e0174944.</mixed-citation><mixed-citation xml:lang="en">Weng S.F., Reps J., Kai J. Can machine-learning improve cardiovascular risk prediction using routine clinical data? PLoS One. 2017; 12 (4): e0174944.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmad T., Lund L.H., Rao P. Predicting early readmission risk for heart failure patients using machine learning. Computers in Cardiology. 2018; 45: 1-4.</mixed-citation><mixed-citation xml:lang="en">Ahmad T., Lund L.H., Rao P. Predicting early readmission risk for heart failure patients using machine learning. Computers in Cardiology. 2018; 45: 1-4.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Razavian N., Blecker S., Schmidt A.M. Population-level prediction of type 2 diabetes from claims data and analysis of risk factors. Big Data. 2015; 3 (4): 277-287.</mixed-citation><mixed-citation xml:lang="en">Razavian N., Blecker S., Schmidt A.M. Population-level prediction of type 2 diabetes from claims data and analysis of risk factors. Big Data. 2015; 3 (4): 277-287.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Chen J.H., Asch S.M. Deep learning in healthcare: Review, opportunities and challenges. Brief Bioinform. 2020; 21 (2): 553-563.</mixed-citation><mixed-citation xml:lang="en">Chen J.H., Asch S.M. Deep learning in healthcare: Review, opportunities and challenges. Brief Bioinform. 2020; 21 (2): 553-563.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Lundberg S.M., Nair B., Vavilala M.S. Explainable machine-learning predictions for the prevention of hypoxaemia during surgery. Nat. Biomed. Eng. 2018; 2: 749-760.</mixed-citation><mixed-citation xml:lang="en">Lundberg S.M., Nair B., Vavilala M.S. Explainable machine-learning predictions for the prevention of hypoxaemia during surgery. Nat. Biomed. Eng. 2018; 2: 749-760.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Siontis K.C., Noseworthy P.A., Attia Z.I. Artificial intelligence-enhanced electrocardiography in cardiovascular disease management. Nat. Rev. Cardiol. 2021; 18: 465-478.</mixed-citation><mixed-citation xml:lang="en">Siontis K.C., Noseworthy P.A., Attia Z.I. Artificial intelligence-enhanced electrocardiography in cardiovascular disease management. Nat. Rev. Cardiol. 2021; 18: 465-478.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Li X., Xu C., Yang L. Predicting heart failure readmission using machine learning techniques. IEEE J. Biomed. Health Inform. 2020; 24 (10): 2833-2840.</mixed-citation><mixed-citation xml:lang="en">Li X., Xu C., Yang L. Predicting heart failure readmission using machine learning techniques. IEEE J. Biomed. Health Inform. 2020; 24 (10): 2833-2840.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Nasir K, Cainzos-Achirica M., van der Aalst C. Machine learning for cardiovascular disease prediction: A meta-analysis. Eur. Heart J. 2022; 43 (2): 167-177.</mixed-citation><mixed-citation xml:lang="en">Nasir K, Cainzos-Achirica M., van der Aalst C. Machine learning for cardiovascular disease prediction: A meta-analysis. Eur. Heart J. 2022; 43 (2): 167-177.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Krittanawong C., Johnson K.W., Rosenson R.S. Machine learning prediction in cardiovascular diseases: a meta-analysis. Sci. Rep. 2021; 11: 1292.</mixed-citation><mixed-citation xml:lang="en">Krittanawong C., Johnson K.W., Rosenson R.S. Machine learning prediction in cardiovascular diseases: a meta-analysis. Sci. Rep. 2021; 11: 1292.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmed M.U., Eklof C., Hossain M.S. Early detection of heart failure using machine learning techniques. Comput. Biol. Med. 2019; 107: 122-130.</mixed-citation><mixed-citation xml:lang="en">Ahmed M.U., Eklof C., Hossain M.S. Early detection of heart failure using machine learning techniques. Comput. Biol. Med. 2019; 107: 122-130.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Ma X., Wang H., Gao L. Machine learning algorithms for heart failure detection and diagnosis. Biomed. Res. Int. 2021; 2021: 1-10.</mixed-citation><mixed-citation xml:lang="en">Ma X., Wang H., Gao L. Machine learning algorithms for heart failure detection and diagnosis. Biomed. Res. Int. 2021; 2021: 1-10.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Yu S., Ma X., Demosthenes S.G. Machine learning models for prediction of heart failure: a systematic review. ESC Heart Fail. 2023; 10 (2): 1081-1092.</mixed-citation><mixed-citation xml:lang="en">Yu S., Ma X., Demosthenes S.G. Machine learning models for prediction of heart failure: a systematic review. ESC Heart Fail. 2023; 10 (2): 1081-1092.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Xie Y., Zhang L., Sun W., Zhu Y., Zhang Z., Chen L., Xie M., Zhang L. Artificial Intelligence in Diagnosis of Heart Failure. J. Am. Heart Assoc. 2025; 14 (8): e039511. https://doi:10.1161/JAHA.124.039511</mixed-citation><mixed-citation xml:lang="en">Xie Y., Zhang L., Sun W., Zhu Y., Zhang Z., Chen L., Xie M., Zhang L. Artificial Intelligence in Diagnosis of Heart Failure. J. Am. Heart Assoc. 2025; 14 (8): e039511. https://doi:10.1161/JAHA.124.039511</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Petmezas G., Papageorgiou V.E., Vassilikos V., Pagourelias E., Tsaklidis G., Katsaggelos A.K., Maglaveras N. Recent advancements and applications of deep learning in heart failure: Α systematic review. Comput. Biol Med. 2024; 176:108557. doi: 10.1016/j.compbiomed.2024.108557</mixed-citation><mixed-citation xml:lang="en">Petmezas G., Papageorgiou V.E., Vassilikos V., Pagourelias E., Tsaklidis G., Katsaggelos A.K., Maglaveras N. Recent advancements and applications of deep learning in heart failure: Α systematic review. Comput. Biol Med. 2024; 176:108557. doi: 10.1016/j.compbiomed.2024.108557</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Yao X., Rushlow D.R., Inselman J.W. Electrocardiogram-based artificial intelligence for the diagnosis of heart failure: a systematic review and metaanalysis. J. Geriatr. Cardiol. 2022; 19: 1-10.</mixed-citation><mixed-citation xml:lang="en">Yao X., Rushlow D.R., Inselman J.W. Electrocardiogram-based artificial intelligence for the diagnosis of heart failure: a systematic review and metaanalysis. J. Geriatr. Cardiol. 2022; 19: 1-10.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Frizzell J.D., Liang L., Schulte P.J. Evaluation of machine learning methods for prediction of heart failure mortality and readmission: meta-analysis. BMC Cardiovasc. Disord. 2025; 25: 1-12.</mixed-citation><mixed-citation xml:lang="en">Frizzell J.D., Liang L., Schulte P.J. Evaluation of machine learning methods for prediction of heart failure mortality and readmission: meta-analysis. BMC Cardiovasc. Disord. 2025; 25: 1-12.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Angraal S., Mortazavi B.J., Gupta A. Heart Failure Diagnosis, Readmission, and Mortality Prediction Using Machine Learning and Artificial Intelligence Models. Curr. Epidemiol. Rep. 2020; 7: 1-9.</mixed-citation><mixed-citation xml:lang="en">Angraal S., Mortazavi B.J., Gupta A. Heart Failure Diagnosis, Readmission, and Mortality Prediction Using Machine Learning and Artificial Intelligence Models. Curr. Epidemiol. Rep. 2020; 7: 1-9.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Siontis K.C., Liu K., Bos J.M. AI-Assisted ECG. J. Am. Heart Assoc. 2024; 13: 1-8.</mixed-citation><mixed-citation xml:lang="en">Siontis K.C., Liu K., Bos J.M. AI-Assisted ECG. J. Am. Heart Assoc. 2024; 13: 1-8.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Digital Watch Observatory. Concept of development of artificial intelligence in Kazakhstan for 2024-2029. https://dig.watch/resource/kazakhstansconcept-for-the-development-of-artificial-intelligencefor-2024-2029</mixed-citation><mixed-citation xml:lang="en">Digital Watch Observatory. Concept of development of artificial intelligence in Kazakhstan for 2024-2029. https://dig.watch/resource/kazakhstansconcept-for-the-development-of-artificial-intelligencefor-2024-2029</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Beisekeeva A.K., Kairgaliyev R.Sh. Artificial Intelligence in Cardiology. Vestnik KazNMU. 2022; 1: 45-51.</mixed-citation><mixed-citation xml:lang="en">Beisekeeva A.K., Kairgaliyev R.Sh. Artificial Intelligence in Cardiology. Vestnik KazNMU. 2022; 1: 45-51.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
